Diverse Regions Research Articles

Drivers of arthropod biodiversity in an urban ecosystem

Our world is becoming increasingly urbanized with a growing human population concentrated around cities. The expansion of urban areas has important consequences for biodiversity, yet the abiotic drivers of biodiversity in urban ecosystems have not been well characterized for the most diverse group of animals on the planet, arthropods. Given their great diversity, comparatively small home ranges, and ability to disperse, arthropods make an excellent model for studying which factors can most accurately predict urban biodiversity. We assessed the effects of (i) topography (distance to natural areas and to ocean) (ii) abiotic factors (mean annual temperature and diurnal range), and (iii) anthropogenic drivers (land value and amount of impervious surface) on the occurrence of six arthropod groups represented in Malaise trap collections run by the BioSCAN project across the Greater Los Angeles Area. We found striking heterogeneity in responses to all factors both within and between taxonomic groups. Diurnal temperature range had a consistently negative effect on occupancy but this effect was only significant in Phoridae. Anthropogenic drivers had mixed though mostly insignificant effects, as some groups and species were most diverse in highly urbanized areas, while other groups showed suppressed diversity. Only Phoridae was significantly affected by land value, where most species were more likely to occur in areas with lower land value. Los Angeles can support high regional arthropod diversity, but spatial community composition is highly dependent on the taxonomic group.

Taxonomic diversity and abundance of enchytraeids (Annelida, Clitellata, Enchytraeida) in the Northern Palaearctic. 1. Asian part.

Enchytraeids, or potworms, are tiny oligochaetes that are distributed worldwide in many terrestrial, freshwater and marine ecosystems. Despite their key role in the functioning of ecosystems, the diversity and abundance of Enchytraeidae are rarely studied due to the laborious process of species identification. The present study addresses this gap and sheds some light on the distribution and abundance of enchytraeids in the lands of the Northern Palearctic. The provided dataset constitutes the latest and comprehensive field sampling of enchytraeid assemblages across the Asiatic part of the Northern Palearctic, encompassing an original set of soil samples systematically collected throughout the region from 2019 to 2022. The dataset includes occurrences from 131 georeferenced sites, encompassing 39 species and 7,074 records. This represents the first dataset providing species-specific information about the distribution and abundance of terrestrial enchytraeids across an extensive geographic area covering the Asian sector of the Northern Palaearctic. The compiled dataset is the key for exploring and understanding local and regional enchytraeid diversity. It may also serve as a valuable resource for monitoring and conserving the entire soil biodiversity.

A promising model of natural-economic diversity in the Carpathian-Podillia region in Ukraine in the context of national and regional interests


 
 
 A promising model of natural-economic diversity in the Carpathian-Podillia region in the context of national and regional interest is based on rational use of agricultural, water economy, recreation tourism, forest land, and human settlement resources. The foundation of the model was a rational, historically formed use of nature and natural resources, which are essential for the optimal functioning of the Carpathian-Podillia region in Ukraine. In the article, besides the traditional types of nature use, we analyzed new creative kinds – recreation tourism, human settlement, nature protection and others, which are currently oriented at sustaining the ecological balance in the region in order to promote optimal living and work conditions for the people. In the system of state management of the processes of nature use in Ukraine, the dominating tendency is strengthening of the regional territorial link of management, which obviously is related to ecological issues. Over the recent decades, the national spend on environmental protection has increased. The state has improved the regulations of nature use by establishing methods to identify and reverse processes of environmental pollution, as well as regulation of the mechanism of ecological expertise. The national environmental policy has attained a vector towards a sustainable nature use. One of its moving forces is legal responsibility for nature use, adoption of a number of laws of environmental protection and creation of respective institutions of state-administrative management. The expenditure on combating environmental pollution approached 2% of Ukraine’s GDP. Important components in the structure of state ecological regulation are state and foreign investments. The main capital investments in environmental protection and rational use of natural resources are car- ried out for the following spheres: rational use of water, land, forest, fishery resources; protection of atmosphere air. The greatest share of material support goes to water, land, and mineral resources.
 
 

Amelioration of nutritional properties of bakery fat using omega-3 fatty acid-rich edible oils: a review.

Bakery products have gained prominence in modern diets due to their convenience and accessibility, often serving as staple meals across diverse regions. However, the fats used in these products are rich in saturated fatty acids and often comprise trans fatty acids, which are considered as a major biomarker for non-communicable diseases like cardiovascular disorders, obesity and diabetes. Additionally, these fats lack the essential omega-3 fatty acids, which are widely known for their therapeutic benefits. They play a major role in lowering the risk of cardiovascular diseases, cancer and diabetes. Thus, there is need for incorporating these essential fatty acids into bakery fats. Nevertheless, fortifying food products with polyunsaturated fatty acids (PUFAs) poses several challenges due to their high susceptibility to oxidation. This oxidative deterioration leads to not only the formation of undesirable flavors, but also a loss of nutritional value in the final products. This review focuses on the development of healthier trans-fat-free bakery fat enriched with omega-3 fatty acids and its effect on the physicochemical, functional, sensory and nutritional properties of bakery fats and products. Further, the role of various technologies like physical blending, enzymatic interesterification and encapsulation to improve the stability of PUFA-rich bakery fat is discussed, where microencapsulation emerged as a novel and effective technology to enhance the stability and shelf life. By preventing deteriorative changes, microencapsulation ensures that the nutritional, physicochemical and sensory properties of food products remain intact. Novel modification methods like interesterification and microencapsulation used for developing PUFA-rich bakery fats have a potential to address the health risks occurring due to consumption of bakery fat having higher amount of saturated and trans fatty acids. © 2023 Society of Chemical Industry.

Genome-wide detection of selection signatures in Jianli pigs reveals novel cis-regulatory haplotype in EDNRB associated with two-end black coat color

BackgroundJianli pig, a renowned indigenous breed in China, has the characteristics of a two-end black (TEB) coat color, excellent meat quality, strong adaptability and increased prolificacy. However, there is limited information available regarding the genetic diversity, population structure and genomic regions under selection of Jianli pig. On the other hand, the genetic mechanism of TEB coat color has remained largely unknown.ResultsIn this study, the whole genome resequencing of 30 Jianli pigs within a context of 153 individuals representing 13 diverse breeds was performed. The population structure analysis revealed that Jianli pigs have close genetic relationships with the Tongcheng pig breed, their geographical neighbors. Three methods (observed heterozygosity, expected heterozygosity, and runs of homozygosity) implied a relatively high level of genetic diversity and, a low inbreeding coefficient in Jianli compared with other pigs. We used Fst and XP-EHH to detect the selection signatures in Jianli pigs compared with Asian wild boar. A total of 451 candidate genes influencing meat quality (CREBBP, ADCY9, EEPD1 and HDAC9), reproduction (ESR1 and FANCA), and coat color (EDNRB, MITF and MC1R), were detected by gene annotation analysis. Finally, to fine-map the genomic region for the two-end black (TEB) coat color phenotype in Jianli pigs, we performed three signature selection methods between the TEB coat color and no-TEB coat color pig breeds. The current study, further confirmed that the EDNRB gene is a candidate gene for TEB color phenotype found in Chinese pigs, including Jinhua pigs, and the haplotype harboring 25 SNPs in the EDNRB gene may promote the formation of TEB coat color. Further ATAC-seq and luciferase reporter assays of these regions suggest that the 25-SNPs region was a strong candidate causative mutation that regulates the TEB coat color phenotype by altering enhancer function.ConclusionOur results advanced the understanding of the genetic mechanism behind artificial selection, and provided further resources for the protection and breeding improvement of Jianli pigs.

Vascular plants and mosses as bioindicators of variability of the coastal pine forest (Empetro nigri-Pinetum)

Empetro nigri-Pinetum is a unique sea coast plant community developing along the Baltic Sea from Germany to Lithuania. Our detailed field research of bryophytes and vascular plants has highlighted the regional diversity of the Empetro nigri-Pinetum typicum plant community throughout its range in Central Europe. Our study indicated that vascular plants and mosses effectively discriminate against the described phytocoenoses, thus it was possible to distinguish three variants of the coastal forest: Calluna–Deschampsia (from Germany), Vaccinium vitis–idaea (from Poland) and Melampyrum–Deschampsia (from Lithuania). Redundancy analysis indicated that the division is related to the habitat conditions of the analyzed areas, with humidity having the greatest impact on this differentiation. Kohonen’s artificial neural network (i.e. self-organising map, SOM) confirmed the heterogeneous nature of the studied phytocenoses, and combined with the IndVal index enabled identification of indicator species for respective studied patches: Deschampsia flexuosa for Calluna–Deschampsia group; Aulacomnium palustre, Calluna vulgaris, Carex nigra, Dicranum polysetum, Erica tetralix, Oxycoccus palustris, Sphagnum capillifolium, Vaccinium uliginosum and Vaccinium vitis–idaea for Vaccinium vitis–idaea group; and young specimens of Betula pendula, Lycopodium annotinum, Melampyrum pratense and Orthilia secunda for Melampyrum–Deschampsia group. Thereby, our study showed that individual groups of species can be very good bioindicators for each of the studied phytocoenoses.

Microstructural regulation and mechanical behavior of asymmetrically extruded high-content TC4p reinforced AZ31 composite

Asymmetric extrusion (AE) is frequently used to weaken the texture of magnesium (Mg) alloys to improve their mechanical properties. In this paper, to explore the influence of asymmetric extrusion on the microstructure and mechanical properties of Mg matrix composites (MMCs), we synthesized TC4/AZ31 composite sheets via ball milling coupled with sintering and then various extrusions (including conventional extrusion (CE), transverse-directional AE (TDE), and normal-directional AE (NDE)). The differences in microstructure and performance among the three processed samples were compared and analyzed using SEM, XRD, EBSD characterization and tensile testing. The results showed that the asymmetrically extruded samples achieved better mechanical properties compared to their CE counterparts. It found that the grain refinement was relatively significant and texture evolution was dispersed in AE samples compared to the CE ones, which was attributed to the TC4 particle (TC4p) disturbance and extra asymmetric shear of matrix flow. Three different macro-textures were obtained in various extruded processes, and the micro-texture of each sample changed in diverse regions. Based on grain orientation spread (GOS) analysis, the introduction of TC4p resulted in dynamic recrystallization (DRX) and particle-stimulated nucleation (PSN) effects during the AE process at 350 °C. The mechanisms of the combination of ductility and strength in the AE-processed sheets were related to the finer grains, high Schmid factor (SF), evenly distributed dislocations and scattered texture. This work can also provide the feasibility and prospects of applying asymmetric extrusion to MMCs.

From Anatolian Plateau to American Plains: A transcontinental assessment of the EUMETSAT H SAF’s new generation snow water equivalent product over Türkiye and the conterminous U.S.

The main frame of this paper is to present the first validation results of the new generation hemi-spherical daily snow water equivalent (SWE) product of the EUMETSAT H SAF, namely, H65. It utilizes data from passive microwave radiometry sensors to estimate SWE. Operating at a suitable spatial scale, it offers insights into snow accumulation and melting dynamics, advancing satellite-based snow monitoring across diverse regions. The validation period covers the 2021 snow year, from January to March 2021, during which the dry snow conditions prevail. The validation is conducted in two distinct geographic regions, Türkiye, and the conterminous U.S. For Türkiye, the in-situ snow depth measurements provided by the Turkish State Meteorological Service are employed. On the other hand, the 1-km gridded SWE dataset of NOAA National Ice and Snow Data Center is used in the validation over the U.S. The validation results over Türkiye yields an overall RMSE of 39.27 mm, whereas it reads 15.19 mm for the U.S. These results indicate that the H65 SWE product complies with the product requirement thresholds for both flat (40 mm) and mountainous (45 mm) areas.

Experiences of discrimination and language brokering: Exploring risks and protective factors.

Language brokering (LB) often occurs in public places, putting youth who broker at risk for experiencing discrimination while engaging in brokering. Guided by the risk and resilience theoretical framework, the present study goals were twofold: (a) to examine the association between discrimination and LB, and (b) to explore moderating abilities of ethnic identity and family dynamics. Data were collected from 458 young adults (Mage = 21.36, 80% female). Participants were from a diverse region in the United States, and a majority of them self-identified as Latino (66.2%). Participants were invited to complete a one-time online survey about their LB and family experiences. We found that discrimination was negatively associated with LB for these young people. Specifically, discrimination was related to higher LB burden and higher LB role reversal, and lower LB efficacy. In addition, we found that ethnic-racial identity (ERI) acted as a moderator of LB role reversal against discrimination, and that negative family dynamics moderated the association between discrimination and LB. Positive family dynamics were not successful in buffering against negative effects of discrimination. Our findings indicate that young people who broker seem to be negatively impacted by discrimination. The effects of discrimination on LB role reversal could be alleviated by strong ERI; however, the same is not true for LB burden and LB efficacy. Furthermore, negative family dynamics exacerbated the negative effects of discrimination on LB, and positive family dynamics did not serve as a buffer against discrimination. Implications for those working with language brokers are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

A study on predictive analytics in talent acquisition in Indian companies: An Indian context perspective

In the contemporary Indian business landscape, talent acquisition stands as a pivotal challenge for organizations striving to maintain competitiveness and drive innovation. With the proliferation of data and advancements in analytics technology, predictive analytics has emerged as a promising tool to revolutionize talent acquisition practices. This conceptual paper endeavors to explore the application of predictive analytics specifically within the unique context of Indian companies' talent acquisition endeavors. Beginning with an exploration of the theoretical foundations of predictive analytics in talent acquisition, this paper delves into the intricacies of its implementation in the Indian business ecosystem. By synthesizing existing literature and empirical evidence, it elucidates the potential benefits and challenges associated with predictive analytics adoption in the Indian context. In particular, the study investigates the socio-economic and cultural nuances that shape talent acquisition strategies in India, including the significance of factors such as regional diversity, educational disparities, and socio-economic backgrounds. It examines how these contextual factors influence the design, implementation, and outcomes of predictive analytics initiatives in talent acquisition. Furthermore, the paper provides insights into the current landscape of predictive analytics utilization in Indian companies' talent acquisition processes. It discusses notable trends, case studies, and success stories, shedding light on the transformative impact of predictive analytics on recruitment efficiency, candidate quality, and workforce diversity. Moreover, the study addresses the ethical and legal considerations inherent in the deployment of predictive analytics in talent acquisition within the Indian regulatory framework. It emphasizes the importance of ethical data practices, transparency, and accountability to mitigate risks related to privacy infringement and algorithmic bias. Additionally, the paper identifies key challenges hindering the widespread adoption of predictive analytics in Indian talent acquisition, such as data quality issues, talent scarcity in analytics expertise, and organizational resistance to change. It offers strategic recommendations for overcoming these barriers, including investment in data infrastructure, capacity-building initiatives, and stakeholder engagement. In conclusion, this study contributes to the advancement of knowledge in both academic and practical domains by offering a comprehensive understanding of predictive analytics in talent acquisition within the Indian context. By addressing the unique challenges and opportunities specific to the Indian business environment, this paper aims to inform strategic decision-making and drive organizational success in talent acquisition endeavors.

A Comparative Study of the Use of Atamagala in Suniyam Shanthikarmaya in the Upcountry, Lowcountry and Sabaragamu Traditions

Atamagala is an unique cultural aspect related to Sinhala folk practices & applications. Among them, the use of Atamagala is more famous as a decoration of Shanthikarma. Sooniyam Shanthikarmaya, which is conducted with the primary objective of eliminating witchcraft, is unique among the Shanthikarma used in Atamagala. The primary objective was to study the use of Atamagala, which is a decoration included in the Souniyam Shanthikarma, which is held with regional diversity in the Upcountry, Lowcountry and Sabaragamuwa, in a comparative manner and does the use and utility of Atamagala change in aforementioned traditions was the research problem. This research utilizes the human genealogical method, conducted under the qualitative method. Library study and field study were used as data collection methods. The methods of field data collection were the observation of Shanthikarma which uses Atamagala, observation of Atamagala creating method and conducting interviews with the experts in the field. Twelve data contributors were selected under judgmental sampling and snowball sampling and interviewed in this research. Atamagala is a basic arrangement built as a house, which is created by using banana pith and banana leaves and a “Yantraya” with eight corners marked inside and a mat is spread in such a way that the patient can sit on it. The primary objective of Atamagala practice is to remove the dosha of the patient. According to the three traditions, diversity can also be identified in the preparation of Atamagala and related rituals in Sooniyam Shanthikarmaya. Although, the Atamagala is a formal structure in Lowcountry and Sabaragamuwa traditions, it is a primitive structure in Upcountry Sooniyam Shanthikarmaya. It is also an unique custom not to cut Atamagala in Upcountry and Sabaragamu tradition. Accordingly, the research is concluded with the fact that the use and utility of Atamagala in Sooniyam Shanthikarma varies according to the traditions.

A comparative study of the hypolipidemic effects and mechanisms of action of Laminaria japonica- and Ascophyllum nodosum-derived fucoidans in apolipoprotein E-deficient mice.

The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that Laminaria japonica- and Ascophyllum nodosum-derived fucoidans have type I and type II fucosyl chains, respectively. These chemical differences may contribute to distinct hypolipidemic effects and mechanisms of action. Chemical analysis demonstrated that the percentage contents of sulfate, glucuronic acid, and galactose were higher in L. japonica-derived fucoidans than those of A. nodosum-derived fucoidans. In hyperlipidemic apolipoprotein E-deficient mice, both A. nodosum- and L. japonica-derived fucoidans significantly decreased the plasma and hepatic levels of total cholesterol and triglyceride, leading to the reduction of atherosclerotic plaques. Western blotting experiments demonstrated that these fucoidans significantly enhanced the expression and levels of scavenger receptor B type 1, cholesterol 7 alpha-hydroxylase A1, and peroxisome proliferator-activated receptor (PPAR)-α, contributing to circulating lipoprotein clearance and fatty acid degradation, respectively. Differentially, L. japonica-derived fucoidan significantly increased the LXR/ATP-binding cassette G8 signaling pathway in the small intestine, as revealed by real-time quantitative PCR, which may lead to further cholesterol and other lipid excretion. Collectively, these data are useful for understanding the hypolipidemic mechanisms of action of seaweed-derived fucoidans, and their potential application for the prevention and/or treatment of atherosclerotic cardiovascular diseases.

Пространственные и структурные закономерности в распределении научно-технологической, инновационной и производственной деятельности в России

A modern innovative economy relies on the continual integration of knowledge and tech­nologies into production, monitoring, and management processes. Therefore, territorial proximity and sectoral complementarity of the activities of scientific, technological and industrial organisations are crucial factors in fostering innovation. This article aims to assess the relationship between a region’s economic and scientific specialisation and the level of its innovative development. The object of the study is the industrial and research profile of Russian regions’ economies with a focus on the strength of connections between them. We identified and measured Russian regions’ industry-specific research, technolog­ical and economic specialisations. Additionally, we described the spatial and structural patterns of interregional distribution and concentration of research, technological and in­novative activities. Methodologically, we compared data on the product output by industry, using the OKVED classification subgroups and information on the costs and implemen­tation of R&D. To gather the latter data, we employed our methodology, which involved juxtaposing GRNTI and OKVED codes. Overall, we analysed data from 17.3 thousand re­search, development and technological projects conducted between 2017 and 2021 across 18 fields. Specialisation coefficients for both the supply and demand of R&D outcomes and production were computed for each region. The econometric analysis made it possible to distinguish four clusters of regions based on their research and industrial specialisation: agro-industrial regions, mechanical engineering regions, precision engineering regions and diversified regions. The study demonstrated a correlation between a region’s innova­tive product output and the structure of its innovative economy.

Technological Diversification and Resilience of European Metropolitan Regions

Technological Diversification and Resilience of European Metropolitan Regions

Livelihood Diversification and Rural Household Economic Security in Central and Bundelkhand Regions of Uttar Pradesh, India

Livelihood Diversification and Rural Household Economic Security in Central and Bundelkhand Regions of Uttar Pradesh, India

Plausible Influence of HLA Class I and Class II Diversity on SARS-CoV-2 Vulnerability.

Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the global coronavirus disease 2019 (COVID-19) pandemic, which adversely affected almost all aspects of human life and resulted in the loss of millions of lives, while affecting nearly 0.67 billion people worldwide. SARS-CoV-2 still poses a challenge to the healthcare system as there are more than 200,000 active cases of COVID-19 around the globe. Epidemiological data suggests that the magnitude of morbidity and mortality due to COVID-19 was low in a few geographical regions and was unpredictably higher in a few regions. The genetic diversity of different geographical regions might explain the sporadic prevalence of the disease. In this context, human leukocyte antigens (HLA) represent the most polymorphic gene-dense region of the human genome and serve as an excellent mini-genome model for evaluating population genetic diversity in the context of susceptibility and progression of various diseases. In this review, we highlight the plausible influence of HLA in susceptibility, severity, immune response, and designing of epitope-based vaccines for COVID-19. Further, there is a need for extensive investigations for illustration and clarification of the functional impact of HLA class I and II alleles in the pathogenesis and progression of SARS-CoV-2.

Fish diversity and distribution in the Nanling region

Fish diversity and distribution in the Nanling region

Mitochondrial DNA diversity and maternal origins of Pakistani donkey.

Domestic donkey plays a key role as a draft animal in rural economy of Pakistan where its population is increasing every year. The complete mtDNA control region of forty randomly sampled donkeys was PCR- amplified and sequenced bi-directionally using specific primers. Distinct mtDNA haplotypes obtained in the current study (KY446001-KY446011) were subjected to haplotype (h) and nucleotide diversity (π) measures using DnaS as well as to phylogenetic, Network, and AMOVA analyses. There were a total 27 polymorphic sites present within 11 unique mtDNA haplotypes from the studied 40 animals from different regions. Neighbor-joining network and median-joining network both illustrated the splitting of all these haplotypes into two well-defined Nubian and Somali lineages, confirming African maternal origin of Pakistani domestic donkey. Diversity parameters h (0.967± 0.037) and π (0.02917± 0.00307) were found to reveal high levels of genetic diversity in Pakistani donkeys. AMOVA demonstrated only 1% of genetic differences between two mtDNA maternal lineages, pointing to lack of population substructure in Pakistani donkeys as is the case with worldwide domestic donkey population. Pakistani donkeys have African maternal origin and high levels of mtDNA diversity. High genetic diversity may be due to non-selective breeding and heteroplasmy. We herein provide the first report on mtDNA diversity of control region in Pakistani domestic donkey.

Novos dados de ocorrência do cogumelo tóxico Chlorophyllum molybdites (Basidiomycota, Agaricaceae) na região amazônica brasileira

ABSTRACT Chlorophyllum molybdites (Agaricaceae) is a toxic mushroom that occurs in Brazil, mostly in the southern region, where cases of poisoning due to accidental ingestion accumulate. In the Amazon region, the species is little known. Here we report the first confirmed occurrence record for the state of Pará. We expand the geographic distribution of C. molybdites and provide a morphological description of the specimens found, contributing to the knowledge of fungal diversity in the Brazilian Amazon region.

Functions and Clinical Significance of Myocardial Cell-Derived Immunoglobulins.

Immunoglobulins (Igs) have been widely accepted to be exclusively expressedby B cells. Nonetheless, this theory is challenged by mounting evidence which suggests thatIgs can also be generated by nonB cells (nonB-Ig), including cardiomyocytes (CM). NonB-Ig exhibits unique physical and chemical characteristics, unique variable region sequences and functions, which diverge from those of B-Ig. For instance, nonB-Ig demonstrates hydrophobicity, limited diversity in the variable region, and extracellular matrix protein activity. Likewise, cardiomyocytes can express different classes of Igs, including IgM, IgG, and free Igκ light chains (cardiomyocyte derived-Igs, CM-Igs). In particular, CM-Igs can be secreted into the extracellular space in various cardiovascular diseases, such as myocardial ischaemia and myocardial fibrosiswhere they might be involved in complement activationand direct damage to cardiomyocytes. Nevertheless, the precise pathological activity of CM-Igs remains unclear. Recently, Zhu et al. focused on studying the sequence characteristics and functions of CM-Igκ; they discovered that the CM-Igκ exhibits a unique VJ recombination pattern, high hydrophobicity, and isprincipally located on the intercalated discs and cross striations of the cardiomyocytes. Interestingly, loss of Igκ in cardiomyocytes results in structural disorders in intercalated discs and dysfunction in myocardial contraction and conduction. Mechanically, Igκ promotes the stabilisation of plectin, a cytoskeleton cross-linker protein that connects desmin to desomsome, to maintain the normal structure of the intercalated disc. This finding indicatesthatCM-Igκ plays an integral role in maintaining cytoskeleton structure. Consequently, it is imperative to reveal the physiological functions and mechanisms of pathological injury associated with CM-Igs.