Background: In this paper, we describe how we developed a conceptual model of the pathway from the cycle of violence to the circle of healing, through our exploration of a community mobilization process in Indigenous communities in Canada. Indigenous communities in Canada have experienced multiple traumas since first contact, with systematic harms across generations. Research has shown that community-based prevention programs for Indigenous populations can be effective in addressing a range of health challenges. Methods: For over 20 years, the Canadian Red Cross has been working with Indigenous communities in violence prevention to address present day challenges. Through a partnership research grant, we have been working to identify, understand document, community processes that address the cycle of violence rooted in colonization and promote healing rooted in Indigenous traditions. Findings: A comprehensive literature review revealed that multiple layers of harm have accumulated and cascaded to explain the deep disruptions in Indigenous community, family, and individual wellbeing. The community stories helped us understand the cycle of violence from colonization that created physical, mental, emotional and spiritual disruption in domains of Indigenous wellbeing. This understanding of disruptions enabled us to consider the pathways that allow wellness to emerge within these four domains. After identifying the pathway to wellness, we realized that a relational lens was essential for the circle of healing. Interpretation: We came to understand that if colonization had disrupted all my relations, then healing and wellness could be understood as a re-integration of all my relations. We believe that our conceptual model can provide guidance to those working with and within diverse Indigenous communities around the world to address the layers of harm from colonization and create culturally relevant pathways to healing and wellness. Funding Statement: Social Sciences and Humanities Research Council of Canada #895-2011-1013. Declaration of Interests: The authors have no conflicts of interest to declare. Ethics Approval Statement: This research was approved by the Aboriginal Research Ethics Review Advisory Group of the Human Participants Review Committee, York University.