Dithiocarbamate Research Articles

Cytotoxicity, anti-microbial studies of M(II)-dithiocarbamate complexes, and molecular docking study against SARS COV2 RNA-dependent RNA polymerase.

Ten transition metal dithiocarbamate (DTC)complexes of the type [M(κ 2‐Et2DT)2] (1–5), and [M(κ 2‐PyDT)2] (6–10) (where M = Co, Ni, Cu, Pd, and Pt; Et2DT = diethyl dithiocarbamate; PyDT = pyrrolidine dithiocarbamate) were synthesized and characterized by different methods. The dithiocarbamate acted as bidentate chelating ligands to afford a tetrahedral complexes with Co(II) ion and square planner with other transition metal ions. The dithiocarbamate complexes showed good activity against the pathogen bacteria species. The results showed the Pt‐dithiocarbamate complexes are more active against all the tested bacteria than the Pd‐dithiocarbamate complex. The dithiocarbamate complexes displayed the maximum inhibition zone against E. coli bacteria, whereas the lowest activity of the dithiocarbamate against Salmonella typhimurium bacteria. The cytotoxicity of the Pd(II) and Pt(II) complexes was screened against the MCF‐7 breast cancer cell line and the complexes showed moderate activity compared with the cis‐platin. The results indicated that the MCF7 cells treated with 500 μg\\ml of ligands and Pd(II) and Pt(II) complexes after 24 hr exposure showed intercellular space and dead cells. Finally, molecular docking studies were carried out to examine the binding mode of the synthesized compounds against the proposed target; SARS COV2 RNA‐dependent RNA polymerase.

Design and Characterization of New Dinuclear Macrocyclic Dithiocarbamate Complexes by the Preparation of a Free Ligand Derived from Isopropylamine

The synthesis and structural characterization of new dithiocarbamate (DTC) ligand and some of its dinuclear transition metal complexes are described. The free dithiocarbamate ligand was prepared through several synthetic routes, including Schiff-base formation. The reaction of 2-aminopropane with terephthaldehyde leads to the formation of Schiff_base which is reduced by methanolic NaBH4 to the corresponding secondary diamine. Diamine( N,N'_ (1,4 phenylenebis (methylene)) bis(propan-2 amine)) reacts with (CS2) in a basic solution of (KOH) to provide the corresponding bis(dithiocarbamate) free_ligand, which undergoes complexation with the appropriate metal (II) chloride to constitute macrocyclic complexes. Characterization of the ligand and its complexes was achieved by FTIR, UV-Vis, melting points, conductance, magnetic susceptibility, and 1H, 13C NMR spectroscopy. The analytical and spectroscopic data were employed to obtain the suggested geometries around metal centres. These studies revealed the formation of dinuclear macrocyclic complexes of the general formula [M(L)]2 (where M= Mn(II) , Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)), with tetrahedral. geometries for Mn(II) , Fe(II), Co(II) and Zn(II), and square. planar geometry with Ni(II) and Cu(II) complexes.

Multiple toxicity of propineb in developing zebrafish embryos: Neurotoxicity, vascular toxicity, and notochord defects in normal vertebrate development

A dithiocarbamate (DTC) fungicide, propineb, affects thyroid function and exerts immunotoxicity, cytotoxicity, and neurotoxicity in humans. Long-term exposure to propineb is associated with carcinogenicity, teratogenicity, malfunction of the reproductive system, and abnormalities in vital signs during organ development. However, there is no evidence of acute toxicity attributable to propineb in zebrafish. Therefore, in the present study, we assessed the toxicity of propineb in zebrafish by studying its adverse effects on embryo development, angiogenesis, and notochord development. Embryos with propineb exposure developed morphological and physiological defects and in larvae, apoptosis and notochord defects were induced in the early development stage. Transgenic fli1:eGFP zebrafish exposed to propineb showed abnormal larval development with defects in angiogenesis and deformed vasculature. Propineb induced irreversible damage to the neural development of embryos and neurogenic defects in developing zebrafish in transgenic olig2:dsRED zebrafish. These results show that exposure to propineb triggers abnormalities in different organ systems of zebrafish and suggests the physiological complexity of the response to propineb.

Substrate evaluation for biobeds in the degradation of ethylene bis-dithiocarbamate in wastewater from pesticide application in banana.

The efficacy of biobeds was evaluated by testing three agricultural residues (sugarcane top, banana stem, and eucalyptus chip) as substrates for the degradation of ethylene bis-dithiocarbamate (EBDC) and ethylene thiourea (ETU) in wastewater from banana spraying. Acrylic columns with a capacity to treat 1L/ea. of wastewater were used as experimental units. Each unit was filled with different proportions of the test substrate (30%, 50% and 70% v/v) and the difference in volume was made up of equal parts of sugar cane cachasse and Fluvisol soil. Subsequently, the units were contaminated with suspensions of 878mgL-1 of EBDC, and the dose was repeated periodically. The ETU concentration and leachate toxicity were evaluated every month for six months. The mixtures with 30% sugarcane top and 50% eucalyptus chip gave the best results, with leachable ETU concentrations down to a level protective of the environment, and toxicity down to background levels or nearly so. This was only found in mixtures with a high C:N ratio (20-25), thus, the effectiveness of the biobeds appears to be related to high lignolytic activity. .

Synthesis of dithiocarbamate-modified crosslinked poly(β−cyclodextrin-co-triethylenetetramine) microspheres for simultaneous and highly efficient removal of Cu2+ and methyl orange/thymol blue from wastewater

Novel dithiocarbamate (DTC)-modified crosslinked poly(β−cyclodextrin-co-triethylenetetramine) microspheres (DTC-PCDTTM) possessing a particle size distribution of 141 μm with a span value of 0.65 were fabricated and evaluated by Cu2+−MO/TB binary-component systems. DTC-PCDTTM shows excellent simultaneous adsorption performance for Cu2+ and methyl orange (MO) or thymol blue (TB) at a DTC graft ratio of 0.21; it also exhibits eminent regeneration and recyclability. The adsorption isotherm data of DTC-PCDTTM for Cu2+ and MO or TB in Cu2+−MO/TB binary-component systems can be described by the Freundlich and Langmuir models, respectively. The adsorption kinetic data of Cu2+, MO, and TB by DTC-PCDTTM are related to the pseudo-second-order kinetic model. The adsorption is a process of spontaneous endothermic entropy increment. The coordination, electrostatic attraction, and the host−guest interaction of β−cD moieties with contaminants are the primary mechanisms for Cu2+, MO, and TB adsorption. In the Cu2+−MO/TB binary-component systems, competitive adsorption is effectively avoided, and Cu2+ shows good synergistic effects with MO and TB.

ASPECTOS GERAIS DA QUÍMICA DOS DITIOCARBAMATOS E DE SEUS COMPLEXOS METÁLICOS E INTERAÇÕES DESSAS ESPÉCIES QUÍMICAS COM IMPORTANTES ENZIMAS – UMA BREVE REVISÃO

GENERAL ASPECTS OF THE CHEMISTRY OF DITHIOCARBAMATES, THEIR METALLIC COMPLEXES AND THEIR INTERACTIONS WITH IMPORTANTE ENZYMES – A BRIEF REVISION. Dithiocarbamates (DTCs) comprise a series of compounds included in the class of 1,1`dithiolates. The application of these organic molecules in the coordination chemistry of some metals is well explored in the last decades, along with their potential applications in medicinal chemistry. In view of our expertise in this field, the syntheses of new DTCS, their coordination chemistry towards various metallic cations and their biocide activities, we summarize in this manuscript the outcomes of some investigations registered in the literature, involving the interactions of DTCs or their complexes with some key enzymes such as carbonic anhydrases, superoxide dismutase, urease, tyrosinase, glutathione, caspases and dehydrogenases. It is provided with a brief introduction of the chemistry of DTCs, electrochemistry, the kinetics of formation, solubility and stability towards solvation. The next topics summarize the results of some experiments concerning the inhibition of these cited enzymes effected by DTCs and some of their coordination complexes. The final remarks and conclusion of the outcomes are provided at the end of the manuscript.

Effects of ethylene-bis-dithiocarbamate (Mancozeb) on zebrafish (Danio rerio) oocytes

Pesticides used to protect plants and animals against the competition of unwanted insects, diseases, and weeds, and pests play a delicate role in living systems. It has adverse effects on the environment and health. The most adverse effects of pesticide derivatives are the reduction in biodiversity, water pollution, and health risks. Mancozeb is an ethylene bis dithiocarbamate (EBDC) pesticide containing manganese and zinc. These pesticides are included in the fungicide group because they are used for treating fungal diseases. In this study, the structure of oocytes developing in female zebrafish exposed to different doses of mancozeb (5 mg L−1, 7.5 mg L−1) was examined. Compared with the control group, it was determined that the number of developing oocytes reduced in the experimental groups. There was a significant increase in atretic oocytes, an increase in the level of degenerate oocytes in a dose-dependent manner, and deformation in oocytes became prominent.

Quantitative detection of dithiocarbamate pesticides by surface-enhanced Raman spectroscopy combined with an exhaustive peak-seeking method.

Surface-enhanced Raman spectroscopy (SERS) based on nanosilver colloid substrates has great potential for rapid detection of pesticide residues because of its advantages of sensitivity, rapidity, simplicity, low cost, etc. However, its poor repeatability and narrow linear quantitative range limit its practical application. In this paper, a silver colloid SERS analysis method combined with an exhaustive peak-seeking method was introduced for quantitative determination of thiram and ziram. This method can establish a linear quantitative relationship in a wide range by use of an own characteristic peak of analysis as an internal standard (IS) which is found via judging the linear correlation between the intensity ratios of two SERS peaks of analytes and the concentrations. Combined with improving the preparation method of silver colloids, adding suitable activators and optimizing the detection process, a liquid detection system with good repeatability and a wide linear quantitation range was obtained. The relative standard deviation (RSD) of the strongest SERS peak is no more than 8.98%, which is better than the general case of the silver colloid SERS substrate. The ratio of I1384/I1148 has a good linear relationship with the concentration of thiram solution, and the 1148 cm-1 characteristic peak was utilized as the IS to establish the standard curve equation for the determination of thiram concentration. The equation is I1384/I1148 = -1.7930 × lg[cthiram (ppm)] + 6.0078 with a linear range of 10-2 to 102 ppm (4.16 × 10-8 to 4.16 × 10-4 mol L-1) and a limit of detection (LOD) of 10-2 ppm. The peak of IS for the determination of ziram concentration is at 938 cm-1, and the equation is I1384/I938 = 4.5531 × lg[cziram (ppm)] + 6.4792 with a linear range of 10-1 to 102 ppm (3.27 × 10-7 to 3.27 × 10-4 mol L-1) and a LOD of 10-4 ppm. Thiram or ziram in apple juice was successfully detected by using this liquid detection system. This analysis system effectively solves the problem of poor repeatability and a narrow linear quantification range in SERS analysis based on silver colloid substrates, and the linear quantification range meets the requirements of the national standard (GB-2763-2019).

Reproductive toxicity in male juvenile rats: Antagonistic effects between isolated agrochemicals and in binary or ternary combinations

The management of agrochemicals in Brazilian agriculture impacts global environmental sustainability and food security, since this country is one of the major agro-food exporters in the world. Acephate, carbendazim, and dithiocarbamates (DTCs) such as mancozeb, are among the most detected agrochemicals in Brazilian agro-food products, occurring in combination in several crops, especially in fruit cultures. The present study evaluated the impact of the exposure to isolated agrochemicals and all the combined possible mixtures (binary and ternary forms) on the reproductive parameters of male juvenile rats, known to be a vulnerable biological system and developmental window. Data were analyzed using Generalized Linear Models (GzLM), considering each agrochemical as an independent factor. The study revealed higher reproductive toxicity exerted by isolated agrochemicals when compared to the combined treatments, which exhibited mostly an antagonistic effect. Results suggest endocrine disruptive effects of each one separately on the weight of reproductive organs and testicular histomorphometry, besides changes in testicular SOD activity. The full factorial experimental design employed here allowed us to conclude that it is not possible to scale-up the effects of the isolated treatments to the mixtures, showing how difficult it is to know beforehand the response and cross-talk among the multiple physiological mechanisms disturbed by complex mixtures. Considering that food products are shared on a global scale and that some of these three agrochemicals have already been prohibited in EU countries, the consumption of some Brazilian products puts global human health at risk, that of children.

Gold nanoparticle stabilized dithiocarbamate functionalized magnetite carbon as promise clean nanocatalyst for A3-coupling organic transformation

A novel, efficient, and core/shell nanosphere catalyst (Fe3O4@C-NHCS-Au0) was successfully synthesized with a movable magnetite core encapsulated in a carbon shell. It was modified using APTES (3-aminopropyltriethoxysilane) to convert dithiocarbamate (DTC) functional group in the carbon surface though post-modification with CS2 (carbon disulfide). Au0-nanoparticles were decorated via DTC binder to improve the catalytic activity. It was applied as a high-efficiency nanocatalyst in promoting three-component A3 coupling reaction of alkynes, aldehydes, and amines for the synthesis of propargyl amines under the optimized condition.

Direct synthesis of piperazines containing dithiocarbamate derivatives via DABCO bond cleavage

DABCO bond cleavage with dithiocarbamic acid salts was applied as a direct synthetic route for the preparation of a novel category of piperazines containing dithiocarbamate functional group. This metal-free and operationally simple approach can be applied with good to excellent yields and high selectivity. Besides, substituted bis-piperazines and piperidines containing dithiocarbamate groups were successfully prepared via the same protocol using quaternized quinuclidine and bis-quaternized DABCO.

Synthesis of Water-Soluble Copolymers of N-vinylpyrrolidone with N-vinyldithiocarbamate as Multidentate Polymeric Chelation Systems and Their Complexes with Indium and Gallium.

Dithiocarbamate (DTC) derivatives of N-vinylpyrrolidone-N-vinylamine (VP–VA) copolymers were synthesized via reaction between the copolymers and carbon disulfide in alkaline medium; molecular masses of the products were 12 and 29 kDa; the VP:VDTC ratios were 94:6 and 83:17 mol.%. Complexation between the obtained DTC derivatives and metal ions (indium and gallium) was investigated. It was demonstrated that metal–DTC ligand complexes with 1:3 ratio between components were formed. Gallium metal–polymer complexes (MPC) were unstable in solution. Individual indium MPC were isolated and characterized by spectral and chromatographic methods. Unlike similar gallium MPC, they appeared to be stable in histidine challenge reaction.

Endocrine-disrupting activity of the fungicide mancozeb used in the Vhembe District of South Africa

Many chemicals released into the environment are believed to disrupt normal endocrine functions in humans and animals. A major group of endocrine disrupting chemicals (EDCs) that could be responsible for reproductive defects are those that mimic natural oestrogens, known as xenoestrogens. A number of in vivo and in vitro screening strategies are being developed to identify and classify xenoestrogens, in order to determine whether they pose a health risk to humans and animals. Oestrogens and androgens mediate their activity via intracellular receptors, directly in muscular tissue, as well as indirectly via stimulation of growth hormones from the pituitary glands and other growth factors from liver plus several other organs. Mancozeb is a metal ethylenebisdithiocarbamate (EBDC) fungicide used to protect many fruits and vegetables and field crops against pathogenic fungal. The T47D-KBluc, GH3.TRE-Luc and MDA-kb2 reporter gene assays were used to determine the possible endocrine disrupting activity/potential of mancozeb. No activity was detected in any of the assays and no mancozeb was detected in any of the dams either. Oestrogenic activity was detected in Albasini Dam, Nandoni Dam and Xikundu weir, but all values were below 0.7 ng l−1 trigger value for oestrogenic activity in drinking water.

Electrical resonant effects of ligands on the luminescent properties of InP/ZnSeS/ZnS quantum dots and devices configured therefrom

Abstract In an effort to finely control the emission spectrum of quantum dot, oleylamine, the original amine ligand which is coordinated on the surface of InP/ZnSeS/ZnS quantum dots (QDs) was replaced by bidentate dithiocarbamate (DTC) ligands having strong coordination ability and electrical resonance structures. 1H NMR (nuclear magnetic resonance) and TGA (thermogravimetric analysis) data showed that some amine ligands on the surface of the QDs were replaced by DTC ligands. The photoluminescence (PL) spectra also show that the emission wavelength of the new QDs is increased by about 1–3 nm depending on the electrical resonant properties of the DTC ligand. QD-LED (light emitting diode) display devices were fabricated using QDs exchanged with DTC ligands and some improvements in the device electronic properties such as current density and luminance were observed.

Multicolor visual screening of total dithiocarbamate pesticides in foods based on sulfydryl-mediated growth of gold nanobipyramids

Dithiocarbamates (DTCs) pesticides were extensively used as fungicides in a variety of crops during their growth, storage and shipment. The DTCs residue in foods will seriously harm human health. In this study, a novel multicolor colorimetric sensor was developed for visual screening of total DTCs (total of ziram, thiram and zineb) based on sulfhydryl-mediated growth of gold nanobipyramids (AuNBPs). We demonstrated that DTCs can absorb on AuNBPs seed’s surface via the formation of Au–S bonds and thus impede the 8-hydroxyquinoline (8-HQ)-promoted AuNBPs growth, which generates DTCs concentration-corresponding color changes. The developed sensor has vivid color changes, short analysis time, higher sensitivity and excellent specificity. It can be used to detect as low as 50 nM of total DTCs by bare eye observation and 17–18 nM of total DTCs by UV–visible spectrometry. By using the multicolor sensor, we have successfully screened total DTCs in apple and black tea by bare eye observation, and detected total DTCs in apple and black tea by UV–visible spectrometry with a recovery of 90%–104% and a relative standard deviation (RSD, n = 5) < 5%. The results obtained with our method consisted well with those obtained with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), verifying that our method had good accuracy and reliability. Especially, the visual detection limit of our method is much lower than the maximum residue limit of total DTCs in vegetable and fruits. All above features make our sensor a promising method for rapid on-site screening of total DTCs in vegetable and fruits by only bare eye observation.

A new spectrophotometric method for the determination of glyphosate: statistical optimization and application in biodegradation studies

Glyphosate (N-phosphonomethylglycine) is extensively used as herbicide against annual and perennial weeds. In the present study, we report a new colorimetric method for the estimation of glyphosate which is based on formation of copper dithiocarbamic acid complex from glyphosate. Glyphosate formed yellow colored complex (λmax = 372 nm) when it was reacted with carbon disulfide (CS2) and copper(II)nitrate in alkaline medium. Using Box–Behnken design (BBD), glyphosate, CS2, copper(II) nitrate, and reaction time were found to influence the absorbance at 372 nm significantly (p < 0.05). The quadratic model developed for the absorbance at 372 nm fitted well to the data (p < 0.0001, F = 21.62, R2= 0.96, adjusted R2= 0.92, predicted R2= 0.75). The optimum concentration of glyphosate, CS2, copper (II) nitrate, and reaction time for maximum absorbance were found to be 500 µg/mL, 1.0% (v/v), 150 µg/mL, and 60 min, respectively. The predicted value of absorbance at 372 nm (0.450) agreed fairly well with the actual value of 0.480. The proposed method obeyed Beer’s law up to 500 µg/mL and showed limit of detection (LOD) and limit of quantitation (LOQ) of 28.9 and 96.4 µg/mL, respectively, with R2of 0.9947. Glycine, aminomethylphosphonic acid (AMPA), cultivation medium components, and soil extract did not interfere in the color complex formation. Using the method, under shake flask conditions, a bacterial isolate Stenotrophomonas maltophilia GP-1 exhibited biodegradation efficiency of 84% after 100 h suggesting that the above method is suitable for study of biodegradation of glyphosate.

Characteristics and Kinetics Study of Mercury Re-emission Inhibited by DTCR in Simulated Desulfurization Slurry

The mercury re-emission characteristics and inhibition effect of sodium dithiocarbamate (DTCR) on mercury re-emission in a simulated desulfurization slurry were investigated. The effects of the desulfurization slurry parameters (including slurry temperature, initial pH value, O2 concentration, and Cl– concentration) on mercury re-emission with and without DTCR were explored. Moreover, the kinetic parameters (reaction order, reaction rate constant, and apparent activation energy) of mercury re-emission and inhibition were calculated by the experimental data. The results showed that addition of DTCR could effectively reduce the mercury re-emission from the desulfurization slurry. The mercury re-emission was enhanced with increases of the slurry temperature and initial pH, while O2 and Cl– in the slurry could inhibit the mercury re-emission. Further study shows that the mercury re-emission reaction processes in the desulfurization slurry with and without DTCR are both consistent with the pseudo-first-order kinetics. In the absence of DTCR, the reaction rate constant of mercury re-emission is 0.01888 min–1, and the apparent activation energy is 44.59 kJ/mol. In the presence of 0.002% DTCR, the reaction rate constant of mercury re-emission is 0.01126 min–1 and the apparent activation energy is 49.08 kJ/mol. Moreover, the effects of slurry parameters on the reaction rate constant were also explored. The present findings are valuable for coal-fired power plants to control mercury re-emission from a desulfurization slurry.

Synthesis, characterization and electrochemical investigation of physical vapor deposited barium sulphide doped iron sulphide dithiocarbamate thin films

Current work has undertaken the synthesis of barium sulphide, ferrous sulphide and barium sulphide doped ferrous sulphide complex using dithiocarbamate (DTC) ligand as single source precursor for the first time in an in-situ mode. Doped metal sulphides were grown into thin films of 840 nm thickness via physical vapor deposition (PVD) on pre-sonicated fluorine doped tin oxide (FTO) inside resistive heating unit (RHU). Prepared metal sulphides and thin films were evaluated for their crystallographic, compositional, optical, microstructural and elemental analysis via X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), ultraviolet visible spectrophotometry (UV-Vis), field emission scanning electron microscopy (FE-SEM), and Rutherford back scattering spectrometry (RBS), respectively. An average crystallite size of 37 nm was exhibited by XRD. FT-IR peaks recorded in the range of 4000–400 cm−1 via potassium bromide palletization technique were indicative of the successful chelation of metal sulphides by DTC. UV-Vis based optical parameters expressed a direct and indirect bandgap of 3.5 and 3 eV, respectively. Exceedingly compact and uniform thin films were exhibited by FE-SEM with development of agglomerated clusters. Strong signals for barium, iron and sulphur were confirmed via RBS having 5 MV pelletron tandom accelerator with an alpha beam of 2.08 MeV made normally incident on the target sample and scattered at an angle of 170°. Electrochemical investigation i.e. cyclic voltammetry (CV), linear sweep voltammetry (LSV) and chronoamperometry (CA) of the fabricated thin films expressed impressive electrical characteristics with a specific capacitance of 34.06 Fg−1 at 10 mV/s and a functional stability for 1900 s at 100 mA. Fabricated films possess a suitable candidacy for utilization in photovoltaic and electrochemical contraptions.

Synthesis and Study of Antimicrobial Activity of 2-Dithiocarbamate-N-(9,10-Dioxo-9,10- Dihydroanthracenyl)Acetamides

The global emergence and dissemination of multidrug-resistant fungal and bacterial pathogens is a serious public health threat. The development of novel highly active antimicrobial compounds simultaneously targeting several targets in bacterial or fungal pathogens could help to fight antimicrobial resistance. The four-component one-pot two-step facile synthesis of a new 2-dithiocarbamate-N-(9,10-dioxo-9,10-dihydroanthracenyl)acetamides 3a-n by the interaction of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracenyl)acetamide 1 or 2 with a series of in situ generated potassium salt of dithiocarbamic acids in DMF-H2O is presented. Evaluation of the antimicrobial activity of the synthesized compounds against bacteria strains Escherichia coli В-906, Staphylococcus aureus 209-Р, Mycobacterium luteumВ-917, and fungi Candida tenuis VKM Y-70, Aspergillus niger VKM F-1119 has been carried out by the diffusion in agar method and by the serial dilution technique. It has been established that synthesized compounds 3a, 3i, 3j have the good antibacterial activity against strain M. luteum at a concentration of 0.5% and the dithiocarbamates 3b, 3i, 3j, 3n demonstrate antifungal effect against C. tenuis at the same concentration. The results of the serial dilution technique showed that compound 3j has high antibacterial action at MIC 3.9 μg/ml.

Effect of dithiocarbamate chelate ligands on the optical properties of InP/ZnS quantum dots and their display devices

The optical properties of colloidal quantum dots (QDs), which show unique luminescent properties in comparison with bulk materials, are generally dependent on the size of the core and shell of the QD, but are also significantly affected by ligands attached to the QD's surface. In this study, we investigated not only the effect of ligand substitution on the optical properties of the QD itself but also the QD-light emitting diode (QD-LED) in which the QD was embeded as a light-emitting material. The monodentate amine ligands of InP/ZnS QDs were replaced by bidentate dithiocarbamate (DTC) chelate ligands capable of imparting delocalization property to the surface of InP/ZnS QDs. 1H NMR spectrum showed that the native ligands were partially exchanged with the DTC ligands. Photoluminescence (PL) spectra before and after ligand substitution show a bathochromic shift of about 10–25 nm depending on the electrical resonant properties of the DTC ligands. The QD-LED device was fabricated using QDs replaced by DTC ligands, and some improvements in device properties were observed. Here, we first report the ligand dependence of the photo- and the electroluminescence of InP/ZnS QDs in solution and device.