Disubstituted Piperidines Research Articles

Stereochemistry in solution. I. Stereochemistry of symmetrically substituted dimethylpiperidinium salts in aqueous solutions.

The cis-trans assignment of methyl groups of symmetrically disubstituted piperidines was done by inspection of NMR spectra of their N, N-dimethyl derivatives. The conformation of N-methyl group of N-monomethyl derivatives was discussed in taking account of the intermolecular interaction with solvent molecule in addition to the intramolecular steric hindrances.

The Synthesis of Certain Disubstituted Piperidines

Several isomers of 2,6-bis-(1-hydroxyalkyl) piperidine hydrochlorides, in which the alkyl group is propyl, butyl, pentyl, hexyl, and benzyl have been prepared by hydrogenating the corresponding five 2,6-diacylpyridine intermediates. 3,5-Diphenylpieridine and a by-roduct, 2,4-diphenylpentamethylenediamine dihydrochlorde, were also prepared. The disubstituted piperidines are to be tested for pharmacological activity.