Mood Disturbance Research Articles

POMS and eye movement: Two indicators for performance in athletics

BackgroundRegularly and scientifically participating in athletics is beneficial for physical and mental health. Mood or emotions are important component of psychology and a major indicator of physical and mental health. Positive and negative mood or emotions can have a strong impact on physical responsiveness. The aim of the present study was to explore whether mood or emotional state influence performance in athletics. MethodsMood, analyzed by Profile of Mood States, and emotional state, reflected by eye movement (looking at times and length), were used to predict track or field performance in training and competition. Results1. The profile of track training (except 3rd week) resembled an iceberg profile (highest vigor scores) and the profile on the 3rd week resembled a “melting” iceberg profile, in which positive mood (vigor and self-esteem) was decreased and negative mood, particularly depression and anger, was significantly increased. The profile of field training almost overlapped, with the exception of depression decreasing markedly on the 3rd and 4th weeks. 2. Positive mood overpowered negative mood, particularly following a track competition; positive emotions exceed negative emotions following track and field competition. 3. The results of the regression analysis showed that an improvement in track performance was negatively correlated with a rise in total mood disturbance (TMD), and field performances were positively correlated with positivity of emotion, as tested by eye movement. 4. Good performance in track events appeared to be associated with decreased vigor and increased fatigue during 3rd and 4th track training; decreased depression and fatigue, and increased vigor as well as low observe length of watching negative emotional pictures (NEPs) before track competition. A good performance in field events appeared to be associated with anger decrease and confusion increase, increased fixation counts of watching positive emotional pictures (PEPs), and decreased fixation and observe counts of watching NEPs before field competition. ConclusionsThe present study proved that different indicators appeared to measure different sport performances: More indicators of Profile of Mood States inclined to predict track performance, while more eye movement indicators could predict field performance. Mixed methods could provide a better understanding of performance than a single approach alone. These findings provided theoretical support and supplementary data for practical applications in the design of comprehensive training programs.

Depression Among Tuberculosis Patients and its Socio-Demographic Correlates: A Cross-Sectional Study from Western Maharashtra

Abstract Introduction: Tuberculosis being a public health challenge has mental illness as a significant, hidden challenge. Tuberculosis-related perceived stigma and social support remain poorly understood in the developing world and the data on the assessment of perceived stigma and social support remain scarce. The present study was conducted to estimate the prevalence of depression in tuberculosis and its association with social support and perceived stigma. Materials and Methods: A cross-sectional analytical study was conducted at the Directly Observed Treatment Short course (DOTS) center in the government medical college of Western Maharashtra. Pretested and prevalidated questionnaires were used for data collection with face-to-face interviews carried out among study participants. Results: Overall, the prevalence of depression including mild mood disturbances was 26/160 (16.25%). Among various socio-demographic correlates, we found a significant association (P = 0.001) of marital status with depression in tuberculosis. it was found that there was a significant association between perceived stigma with depression (P = 0.001). The odds of depression among participants with perceived stigma was 15.24 times more (OR = 15.24) in comparison to the odds of depression in participants with no perceived stigma. Similarly, it was found that there was a significant association between poor social support with depression (P = 0.02). The odds of depression in participants with good social support were 72% lesser (OR = 0.28) than the odds of depression among participants with poor social support. Conclusion: In conclusion, this study highlights that depression is highly prevalent among patients with tuberculosis. Depression among tuberculosis patients was significantly associated with poor social support and perceived stigma. Thus, to improve tuberculosis treatment adherence, a patient-centric approach should be considered at the programmatic level with social support and awareness generation and other measures to mitigate stigma as its key components.

Parental criticism affects adolescents’ mood and ruminative state: Self-perception appears to influence their mood response

Feeling and/or being criticized is a known risk factor for various psychiatric disorders in adolescents. However, the link between the experience of social stressors and the development of psychopathological symptoms is not yet fully understood. Identifying which adolescent subgroups are more vulnerable to parental criticism could be of great clinical relevance. In this study, 90 nondepressed 14- to 17-year-old adolescents were exposed to a sequence of auditory segments with a positive, neutral, and finally negative valence, mirroring parental criticism. Their mood and ruminative states were assessed before and after exposure to criticism. We observed an overall increase in mood disturbance and ruminative thoughts. Self-perception appeared to influence these mood changes, whereas no significant influence by perceived criticism, self-worth, or the general tendency to ruminate was found. Emotional awareness seemed to account for some of the variance in positive mood state changes. These findings point to the importance of adolescent self-perception (and emotional awareness) in dealing with parental criticism.

Exploring the prevalence and clinical impact of fibromyalgia syndrome in patients with shoulder diseases: a cross-sectional study.

Fibromyalgia (FM) is a musculoskeletal syndrome characterised by widespread chronic pain often associated with systemic manifestations such as mood disturbances, persistent fatigue, unrefreshed sleep, and cognitive impairment, substantially impacting patients' health-related quality of life. Based on this background, this study aimed to evaluate the prevalence of FM syndrome in patients referring to an outpatient clinic in a central orthopaedic institute for a painful shoulder. The demographic and clinical characteristics of patients fulfilling the criteria for FM syndrome were also correlated with the severity of symptoms. Consecutive adult patients referring to the shoulder orthopaedic outpatient clinic of the ASST Gaetano Pini-CTO, Milan, Italy, to undergo a clinical evaluation were assessed for eligibility in an observational, cross-sectional, monocentric study. Two hundred-one patients were enrolled: 103 males (51.2%) and 98 females (48.8%). The mean age ± standard deviation (SD) of the patients was 55.3 ± 14.3 years in the whole population. Of all the patients, 12 (5.97%) fulfilled the 2016 FM syndrome criteria based on the FM severity scale (FSS). Of these, 11 were females (91.7%, p=0.002). The mean age (SD) was 61.3 (10.8) in the positive criteria sample. Patients with positive criteria had a mean FIQR of 57.3 ± 16.8 (range 21.6-81.5). We found that FM syndrome is more frequent than expected in a cohort of patients referring to a shoulder orthopaedic outpatient clinic, with a prevalence rate (6%) more than double that of the general population (2%).

Kualitas Pelayanan Jemput Bola bagi Warga Disabilitas di Dinas Kependudukan dan Pencatatan Sipil Kota Cimahi

Cimahi City Government initiated “jemput bola” public service for citizen with disability. “Jemput bola” public service is an act of recording electronic citizen identity card (e-KTP) for citizen with disabilty, elderly, and acute sickness by going directly to the their houses. This study aimed to determine the implementation of population administration services through “jemput bola” public service for citizen with disability at the Population and Civil Registration Office of the Cimahi City along with the obstacles that occured during the process. The research method used was qualitative research. Sources of data in this study were interview, direct observation, and document study. The results of this study indicated that in carrying out ball “jemput bola” public service for citizen with disability, there were some obstacles, i.e.: the absence of Standard Operating Procedures, internet network quality, character of citizen with disability, and access toward citizen’s house location. To overcome the main obstacles, researchers created a Standard Operating Procedure document as guidance for “jemput bola” public service for citizen with disability. For internet network problem, officers could prepare a specific internet network system that was worked in the targeted area and also brought up a backup network. For obstacle related to mood disturbance of citizen with disability, officers needed special training to handle challenging situation so they could serve them in a more appropriate way. For obstacle related to access toward citizen’s house location, officers could bring recording equipment to citizen’s house. This research could benefit Cimahi City Office of Population and Civil Registration to improve the quality of “jemput bola” public service for citizen with disability and also as reference for similar research.

Premenstrual Syndrome and Exercise: A Narrative Review

Premenstrual Syndrome (PMS) is a complex physiological and psychological condition that affects a significant number of women during their reproductive years. Although the exact etiology of PMS remains unclear, its symptoms, including mood swings, bloating, irritability, and fatigue, can significantly impair the quality of life for affected individuals. The management of PMS traditionally involves pharmacological interventions; however, emerging evidence suggests that exercise may offer a valuable non-pharmacological approach to alleviate PMS symptoms. This narrative review aims to explore the proposed etiology, prevalence, and impact PMS has on women as well as examine the literature through which exercise can positively influence PMS symptoms. While the existing literature on exercise and PMS is limited and inconclusive, several studies have reported promising results. Regular exercise has been associated with a reduction in physical and psychological symptoms of PMS including pain, fatigue, mood disturbances, and water retention. Furthermore, exercise has demonstrated its potential to enhance overall well-being and mitigate the negative effects of PMS on daily functioning. Further research is warranted to elucidate the optimal exercise prescription, duration, and intensity required to maximize the benefits and improve the understanding of exercise mechanisms on PMS symptomatology.

Clinical features and brain MRI volumetric changes in anti-mGluR5 encephalitis.

Anti-metabotropic glutamate receptor 5 (mGluR5) encephalitis is a rare and under-recognized autoimmune encephalitis. This study is conducted to characterize its clinical and neuroimaging features. Twenty-nine patients with anti-mGluR5 encephalitis (15 new cases identified in this study and 14 previously reported cases) were included in this study and their clinical features were characterized. Brain MRI volumetric analysis using FreeSurfer software was performed in 9 new patients and compared with 25 healthy controls at both early (≤6 months of onset) and chronic (>1 year of onset) disease stages. The common clinical manifestations of anti-mGluR5 encephalitis included cognitive deficits (n = 21, 72.4%), behavioral and mood disturbances (n = 20, 69%), seizures (n = 16, 55.2%), and sleep disorder (n = 13, 44.8%). Tumors were observed in 7 patients. Brain MRI T2/FLAIR signal hyperintensities were observed predominantly in mesiotemporal and subcortical regions in 75.9% patients. MRI volumetric analysis demonstrated significant amygdala enlargement in both early and chronic disease stages compared to healthy controls (P < 0.001). Twenty-six patients had complete or partial recovery, one remained stable, one died and one was lost to follow-up. Our findings demonstrated that cognitive impairment, behavioral disturbance, seizures, and sleep disorder are the prominent clinical manifestations of anti-mGluR5 encephalitis. Most patients showed a good prognosis with full recovery, even in the paraneoplastic disease variants. The amygdala enlargement in the early and chronic disease stages is a distinct MRI feature, which exploratively offer a valuable perspective for the study of the disease processes.

The neural correlates of apathy in the context of aging and brain disorders: a meta-analysis of neuroimaging studies.

Apathy is a prevalent mood disturbance that occurs in a wide range of populations, including those with normal cognitive aging, mental disorders, neurodegenerative disorders and traumatic brain injuries. Recently, neuroimaging technologies have been employed to elucidate the neural substrates underlying brain disorders accompanying apathy. However, the consistent neural correlates of apathy across normal aging and brain disorders are still unclear. This paper first provides a brief review of the neural mechanism of apathy in healthy elderly individuals, those with mental disorders, neurodegenerative disorders, and traumatic brain injuries. Further, following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, the structural and functional neuroimaging meta-analysis using activation likelihood estimation method is performed on the apathy group with brain disorders and the healthy elderly, aiming at exploring the neural correlates of apathy. The structural neuroimaging meta-analysis showed that gray matter atrophy is associated with apathy in the bilateral precentral gyrus (BA 13/6), bilateral insula (BA 47), bilateral medial frontal gyrus (BA 11), bilateral inferior frontal gyrus, left caudate (putamen) and right anterior cingulate, while the functional neuroimaging meta-analysis suggested that the functional connectivity in putamen and lateral globus pallidus is correlated with apathy. Through the neuroimaging meta-analysis, this study has identified the potential neural locations of apathy in terms of brain structure and function, which may offer valuable pathophysiological insights for developing more effective therapeutic interventions for affected patients.

Resting-state functional connectivity in Autoimmune Addison's Disease

Patients with autoimmune Addison’s disease (AAD) are unable to produce glucocorticoids (GCs), mineralocorticoids (MCs) and androgens from the adrenal cortex and therefore require life-long treatment with GCs and MCs. Due to the sensitivity of the brain to cortisol and androgens, brain function might be affected in patients, as the replacement regime cannot mimic the natural rhythmicity of hormonal secretion. Alterations in brain function might predispose to cognitive or mood disturbances. The present study investigated resting-state functional connectivity (rs-fc) in patients with AAD. Resting-state fMRI data was collected from 57 (33 females) patients with AAD and 69 (39 females) control participants, aged 19-43 years. Resting-state brain networks were identified with independent component analysis (FSL MELODIC). Dual-regression analysis was applied to test for group differences in rs-fc in these networks. Within the patient group we tested the association between rs-fc and glucocorticoid replacement dose in mg/m2/day. Significant clusters were identified with threshold free cluster enhancement and considered to be significant at p<0.05. Patients with AAD had increased fc in the bilateral medial orbitofrontal cortex compared to controls. A higher glucocorticoid replacement dose was associated with stronger functional connectivity in several networks in the prefrontal cortex in patients. AAD seems to be associated with stronger fc at rest in an area known to contain a high density of GC receptors. Further research is needed to investigate if this increased activity is part of an adaptive mechanism or if it predisposes to disturbances in mood and executive functioning.

Pain Catastrophizing as a Mediator Between Pain Self-Efficacy and Disease Severity in Patients with Fibromyalgia

BackgroundFibromyalgia (FM) is characterized by chronic widespread pain, fatigue, sleep disturbances, cognitive impairment, and mood disturbance. Both pain catastrophizing and pain self-efficacy have been found to be mediators of pain treatment effectiveness. However, whether pain catastrophizing mediates the association between pain self-efficacy and FM severity remains unclear. AimTo examine whether pain catastrophizing mediates the association between pain self-efficacy and disease severity in patients with FM. MethodsThis cross-sectional study included the baseline data of 105 people with FM from a randomized controlled trial. Hierarchical linear regression analysis was performed to examine the predictive ability of pain catastrophizing for FM severity. Furthermore, we examined the mediating effect of pain catastrophizing on the association between pain self-efficacy and FM severity. ResultsPain self-efficacy was negatively associated with pain catastrophizing (β = −.4043, p < .001). FM severity was positively associated with pain catastrophizing (β = .8290, p < .001) and negatively associated with pain self-efficacy (β = −.3486, p = .014). Pain self-efficacy had a direct effect on FM severity (β = −.6837, p < .001) and an indirect effect on FM severity through the effect of pain catastrophizing (β = −.3352, 95% CI bootstrapping −.5008 to −.1858). ConclusionPain catastrophizing independently predicts FM severity and mediates the association between pain self-efficacy and FM severity. Pain catastrophizing should be monitored through interventions aimed at improving pain self-efficacy to reduce symptom burden in patients with FM.

Stress response during exercise, gut-brain axis, and gut microbiota in athletes: a review of the literature

Fatigue, mood disturbances, lack of performance, and gastrointestinal disturbances are common among athletes during training and competition. Psychosocial and physical demands during intense exercise can initiate a stress response that activates the sympathoadrenal and hypothalamic-pituitary-adrenal axes, resulting in the release of stress and catabolic hormones, inflammatory cytokines, and microbial molecules. The gut is home to trillions of microorganisms that play fundamental roles in many aspects of human biology, including metabolism, neuroendocrine, and immune function. The microbiome and its influence on host behavior, the gut barrier, and immunity is a critical aspect of the gut-brain axis. Data have been obtained showing a high correlation between physical and emotional stress during exercise and changes in the composition of the gastrointestinal microbiota. Modifications to the composition of the microbiota in professional athletes can improve training efficiency, improve athletic performance and shorten the recovery period after intense physical exertion.

A HYPERADRENERGIC STATE IN HYPERTENSION IS ASSOCIATED WITH MOOD DISTURBANCE AND IMPAIRED STRESS-MODULATED VASOMOTOR RESPONSES

Objective: Increasing evidence suggests a high prevalence of affective disorders in hypertension, however, the physiological associations remain unclear. Noradrenergic activation in the central and peripheral nervous systems is a putative mechanism that may explain the link between both conditions. Here, we investigate whether these stress-sensitive co-morbidities may be dependent on basal noradrenergic activity and whether vascular responses to centrally acting stimuli vary according to noradrenergic activity. Design and method: We examined the relation of affective disorders and stress-mediated vascular responses to plasma concentrations of normetanephrine (NMN), a measure of noradrenergic activity, in subjects with primary hypertension. Subjects on antidepressant medication, alpha- and beta-blockers were excluded. The Patient Health Questionnaire (PHQ-9), the 16-item Quick Inventory of Depressive Symptomatology-Self Report (QIDSSR-16), and Generalised Anxiety Disorder-7 (GAD-7) questionnaires were used for the evaluation of symptoms of depression and anxiety. Forearm blood flow (strain gauge plethysmography) was used to assess vascular responses to mental stress (Stroop colour-word test) and slow breathing (by biofeedback), interventions that respectively increase or decrease noradrenergic activity in the pre-frontal cortex and locus coeruleus. Results: 100 subjects (53% male) with (mean ± SD) age 43.4 ± 10.9 years were recruited. 88% of subjects were treated with anti-hypertensive medications and 4% had type 2 diabetes. 31% and 34% of the study population scored moderate to severe depression for PHQ-9 and QIDSSR-16 respectively indicating significant mood disturbance. Scores representing low mood and high anxiety were 2-3-fold higher for hypertensive subjects in the highest compared to lowest NMN tertiles (PHQ-9: 9.2 ± 5.8 vs 3.8 ± 2.7, P &lt; 0.001; QIDSSR-16: 12.3 ± 4.9 vs 4.5 ± 3.5, P = 0.003; GAD-7: 9.0 ± 5.5 vs 4.6 ± 3.8, P = 0.003). Forearm vasodilator responses to mental stress and vasoconstrictor responses to slow breathing were attenuated in those with high compared to low NMN (28.3 ± 21% vs. 47.1 ± 30% increases for mental stress and 3.7 ± 21% vs. 18.6 ± 15% decreases for slow breathing for highest vs. lowest tertiles of NMN, both P &lt; 0.01). Conclusions: A hyperadrenergic state in hypertension is associated with mood disturbance and impaired stress-modulated vasomotor responses. This association may be mediated by chronic stress impinging on pathways regulating central arousal and peripheral sympathetic nerve activity.

ID: 210537 Perceptions of Pain in Menopausal Women Undergoing Spinal Cord Stimulation

Older women transitioning to menopause undergo a myriad of physical symptoms such as low back pain, joint pain, mood disturbances, and chronic pain due to hormonal alterations1. Furthermore, aging results in altered perceptions of pain2. A current need exists to ascertain the benefits of spinal cord stimulation (SCS) in older women. We therefore retrospectively reviewed a prospectively collected database of thoracic SCS patients.

Occupational therapy improves social participation of complex patients discharged from hospital: results of a powered randomized controlled trial

Purpose To verify the effectiveness of experimental occupational therapy plus intensive standard rehabilitation compared to intensive standard rehabilitation alone on the reintegration to social activities of complex patients three months after hospital discharge. Materials and methods Patients with a score ≥ 9 on the Rehabilitation Complexity Scale at admission to an intensive rehabilitation ward were randomized to the control or experimental group. Both groups received intensive multidisciplinary rehabilitation aimed at recovering independence in the basic activities of daily life (ADL). The experimental group also received experimental occupational therapy services to address goals identified through the administration of the Canadian Occupational Performance Measure (COPM). Experimental occupational therapy began during the in-hospital phase and continued in the home-based setting. It consisted of teaching strategies, recommending aids, and providing personalized information regarding available community support. Results Ninety-two individuals with a mean age of 65 years (female 44.6%) were enrolled. The experimental group significantly improved participation measured by the Reintegration to Normal Living Index (mean changes 8.61, 95% CI: 1–16.23, p = 0.027). The performance and satisfaction scores of the COPM, both during hospitalization and after discharge, and independence in ADL also improved. No differences in mood disturbances were found. Conclusion Early post-discharge occupational therapy integrated with multidisciplinary rehabilitation improves the social participation of complex patients. Future research should investigate the concrete feasibility of implementing this complex intervention cost-effectively and in different contexts. Trial registration ClinicalTrials.gov Identifier NCT03668938 (first posted date 13/09/2018)

Updated review on successful control with nicotine replacement therapy for nicotine withdrawal symptoms

Nicotine use as a tool for quitting smoking has a good safety history. Animal studies suggest that nicotine may adversely affect cognitive development in adolescence, but the relevance of these findings to human brain development is disputed. At low amounts, it has a mild analgesic effect. According to the International Agency for Research on Cancer, "nicotine is not generally considered to be a carcinogen." The Surgeon General of the United States indicates that evidence is inadequate to infer the presence or absence of a causal relationship between exposure to nicotine and risk for cancer. Tobacco is dangerous. According to one study trusted source, smoking-related diseases are responsible for about 4,35,000 deaths per year in the United States. That’s about 1 in every 5 deaths in the United States. Stopping smoking, no matter how long you have smoked, can greatly benefit your health. Nicotine creates pleasant feelings in the body and mind. When you use tobacco, your brain releases neurotransmitters such dopamine, the feel-good chemical. This creates a brief feeling of contentment and pleasure. In humans, nicotine from tobacco induces stimulation and pleasure, and reduces stress and anxiety. Smokers come to use nicotine to modulate their level of arousal and for mood control in daily life. Smoking may improve concentration, reaction time, and performance of certain tasks. When a person stops smoking, nicotine withdrawal symptoms emerge. These include irritability, depressed mood, restlessness, anxiety, problems getting along with friends and family, difficulty concentrating, increased hunger and eating, insomnia, and craving for tobacco. Nicotine withdrawal in untreated smokers produces mood disturbances comparable in intensity to those seen in psychiatric out patients. Generally it has been found that nicotine replacement therapies actually give you small amounts of nicotine through a product like gum or a skin patch. While you’ll continue to get some nicotine in your system, you won’t be exposed to any of the other harmful chemicals that are found in tobacco.

0146 Associations Between Mood and Sleep Architecture in Sedentary Office Workers

Abstract Introduction Sleep, and rapid eye movement (REM) sleep in particular, has been suggested to play an important role in mood regulation. Currently, most of this research has come from laboratory settings under constrained conditions; less is known about one’s sleep in their own home. The purpose of this study was to further examine the associations between home-based polysomnography (PSG) sleep parameters and mood disturbance. Methods This cross-sectional study used baseline data from 120 inactive adults with desk-based jobs (52.5% female, 43.8±10.7 y) who were enrolled in an ongoing clinical trial. Mood was assessed using the Profile of Mood States (POMS); its 7 subscales (tension, anger, fatigue, depression, esteem-affect, vigor, confusion) were summed (with a constant of 100) to generate a Total Mood Disturbance (TMD) score with a higher score indicating greater TMD. Sleep stages were assessed after a full workday using one night of at-home PSG. Multiple linear regression models examined associations between sleep stages and mood adjusting for age, gender, and whether the assessment occurred pre- or post-COVID-19 emergence. Results The mean TMD score was 98.6±18.3. On average, participants slept for 397.4±60.0 minutes with a sleep efficiency of 84.6±9.1%. The mean percentage of time spent in REM sleep was 22.5±6.6%; the mean percentage of time spent in non-rapid eye movement (NREM) sleep, stage 1 (N1), stage 2 (N2), and stage 3 (N3) sleep were 7.8±5.0%, 53.7±10.1%, and 16.0±9.1%, respectively. A greater percentage of REM sleep was associated with lower TMD (β=-0.22, p=0.01). A greater percentage of N1 sleep was also associated with lower TMD (β=-0.23, p=0.01). However, neither percent of N2 nor N3 sleep were associated with TMD (p=0.10 and p=0.12, respectively). Conclusion Overall, the findings of this study support current literature that suggests REM sleep plays a significant role in mood regulation. They also suggest, aside from N1 sleep, NREM sleep may not impact mood disturbance. In the future, the effects of sleep architecture on mood disturbance could further be explored through randomized controlled trials. Support (if any) This study was funded by National Institutes of Health (NIH) grants R01HL134809 and R01HL147610.

0632 The relationship of shift work disorder with depression, anxiety, and stress

Abstract Introduction Shift work-related circadian misalignment can adversely impact health and well-being. Shift workers often experience disturbances in mood and impairments in waking vigilance and cognitive performance. Shift workers also commonly experience disturbed sleep. Shift work disorder (SWD) is a circadian rhythm sleep disorder characterized by insomnia symptoms during the sleep episode and sleepiness during the wake episode, temporally associated with shift schedules. Here, we examined the association between SWD and mental health. Methods Participants were adults (18 y+) who engaged in non-standard work shifts (morning, evening, night, rotating, other). Data were collected via online survey, and included questions about demographics, job details, sleep, and mental health. Participants completed the validated SWD Questionnaire, assessing the presence and severity of symptoms, categorizing individuals as high or low risk for SWD based on International Classification of Sleep Disorders criteria. Participants completed the Depression, Anxiety, and Stress Scale-21 (DASS-21). Higher scores on each DASS-21 subscale indicate higher symptom severity. Linear regression was used to determine the relationship between the presence of SWD and depression, anxiety, and stress symptom scores, adjusting for age, gender, shift work type, self-reported work-day sleep duration, and alcohol use frequency. Results Sixty participants were included (60% female, mean age: 37 [SD: 12.2] y). High risk for SWD was seen in 55% of participants. Sleep duration was on average ~40 minutes shorter in those with vs. without SWD (5.61 [1.24] h vs. 6.31 [1.31] h, p=.037). Participants with SWD reported significantly higher depressive symptoms than those without (B=3.59, SE=1.52, 95% CI [0.54, 6.65], p=.022). SWD was not associated with anxiety, and was marginally associated with stress (B=2.48, SE=1.26, 95% CI [-0.06, 5.02], p=.055). Age was significantly associated with lower stress symptoms (B=-0.11, SE=0.05, 95% CI [-0.22, -0.01], p=.029). No other covariates were significantly associated with depression, anxiety, or stress (all other ps ≥.10). Conclusion SWD was common. Its presence was associated with higher severity of depression symptoms. Intervention approaches targeting underlying causes of SWD (e.g., strategic light-dark exposure and cognitive behavioral therapy for insomnia that is adapted for shift work) should be tested as methods to protect shift workers’ mental health. Support (if any)

0231 Slow Wave Activity During Restricted Sleep Buffers Against Negative Effects on Daytime Positive Emotion in Pre-pubertal Children

Abstract Introduction Increased slow-wave activity (SWA) following sleep loss is a well-established physiological marker of increased sleep pressure. Recent research found SWA changes in response to sleep loss partially accounted for next-day decrements in positive affect (Finan et al., 2015; 2017). To our knowledge, however, this line of inquiry has been limited to adults. Recently, we found greater SWA during a night of healthy sleep predicted greater next-day positive emotion among pre-pubertal children (Rech et al., 2022). Here, we explored whether SWA during the second of two nights of partial sleep restriction predicted next-day emotional responses in the same cohort. Methods N=24 healthy, unmedicated children (7 to 11 years) completed a baseline assessment and one night of at-home PSG monitoring (10 hours in bed). Ten days later, children completed one night of at-home sleep restriction (7-hour sleep opportunity) followed by one night of in-lab sleep restriction with PSG monitoring (6-hour sleep opportunity). The next day, children completed an in-lab emotional assessment where they provided arousal and valence ratings in response to positive affective images from the International Affective Picture System (IAPS). Results Controlling for age and total sleep time during the first sleep restriction night, hierarchical multiple regression analyses examined if N3 SWA in frontal, central, and occipital regions during the second sleep restriction night predicted IAPS ratings. In separate models, both frontal, F(1,20)=8.535, p=.008, and occipital SWA density, F(1,20)=12.313, p=.002, predicted valence ratings in response to positive images (where lower scores indicated more positive valence). Conclusion While preliminary, findings indicate relationships between “rebound” SWA after sleep restriction and next-day emotional functioning in pre-pubertal children. Findings suggest that, prior to the pubertal transition, trait-based differences in homeostatic sleep pressure and recovery from sleep loss might alter emotional responding, potentially influencing risk for later mood disturbances. Support (if any) This research was supported by NIMH grant #R21MH099351 awarded to C.A.A.

0173 Improving Well-being by Changing the Shiftwork Schedules at U.S. Navy Watchfloors

Abstract Introduction Watchfloors provide around-the-clock information, intelligence, and technical support to the U.S. military. Active-duty service members (ADSMs) working on these 24/7 watchfloors stand watches to include night shifts and/or frequent shift rotations. Tailoring shiftwork schedules to optimize individual sleep patterns may reduce the negative effects of shiftwork. The purpose of this study was to test whether a new shiftwork schedule would improve ADSM well-being and sleep. Methods ADSMs (N=79; 83.5% males, 91.2% enlisted, 19 to 54 years of age) participated in a two-phase quasi-experimental longitudinal study to assess well-being and sleep before and after the implementation of a new shiftwork schedule. Both schedules involved three rotating shifts: day shift (0730-1530), evening shift (1320-2330), and night shift (2330-0730). The old schedule had 5 successive days on-shift (5-on/4-off) and the new schedule had 4 successive days on-shift (4-on/4-off). Shifts rotated after every off period. Standardized questionnaires were administered while participants were on the old schedule (study start) and ~5 months after switching to the new schedule. The questionnaires included the Pittsburg Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), and the Profile of Mood States (POMS). Sleep was monitored using wearable devices (ŌURA rings). Results POMS total mood disturbance scores were lower (i.e., better) on the new schedule (p&amp;lt; 0.001), as were several POMS sub-scale scores including tension (p&amp;lt; 0.001), depression (p&amp;lt; 0.001), anger (p=0.014), confusion (p&amp;lt; 0.001), and vigor (p=0.029). There was a statistical trend for a decrease in ISI scores from the old schedule to the new schedule (p=0.067). Sleep duration, PSQI, and ESS scores did not differ between schedules (all p&amp;gt;0.05). Conclusion Implementation of a new shiftwork schedule that was tailored to worker sleep patterns was associated with decreased mood disturbance, improvement in negative mood states (e.g., depression and tension), and reduced insomnia symptom severity. Also, the research team received several anecdotal reports of high levels of worker satisfaction with the new schedule. This study demonstrates the positive real-world effects of using basic sleep and circadian methods to tailor shiftwork schedules to improve the well-being of military personnel. Support (if any)

0839 Does CBT-I Dose Improve Depression and Anxiety in Patients Diagnosed with Breast and Prostate Cancer?

Abstract Introduction It has been widely reported in the literature that insomnia, depression, and anxiety are reciprocally related, and that CBT-I not only improves insomnia but also symptoms of depression and anxiety. With respect to cancer, patients of-ten report high co-morbidity of insomnia, fatigue, depression, and anxiety, with fatigue occurring in almost all patients diagnosed with cancer (irrespective of diagnoses and staging) and extending well into survivorship. The underlying mechanisms of fatigue are not well understood and, as such, there could be many contributing factors (e.g., insomnia and mood disturbance). The present analysis is based on a pilot study evaluating whether sleep continuity and CRF is improved by CBT-I dose (4 &amp; 8 [Low dose] vs 10 &amp; 12 [High dose] sessions). The present analysis evaluates whether dose of CBT-I effects depression and anxiety in patients diagnosed with breast and prostate cancer. Methods This descriptive analysis (percent change from pre to post treatment) includes 12 adult subjects (83.3% female, Mage 58.4±7.5yrs.; [Low dose, n=6], [High dose, n=6]). CBT-I was provided by a master therapist via video conferencing (telehealth CBT-I). Subjects were asked to complete sleep diaries and weekly measures of fatigue (FACIT), insomnia severity (ISI), depression (PHQ-9), and anxiety (GAD-7). Results On the PHQ-9, subjects in the Low dose group exhibited a 57% improvement and subjects in the High dose group had a 52% improvement. On the GAD-7, this corresponded to a 26% improvement (High dose group) and 25% improvement. Conclusion As increasingly reported in the literature, CBT-I produced robust effects on depression as assessed by the PHQ-9. The effects on anxiety appear to be less robust. This may be the case because CBT-I’s effects on fatigue are likely to impact a variety of depressive symptoms, where this is less the case for anxiety. Analyses are ongoing, where the relative effects will be adjusted for insomnia-related items and rendered in terms of effect sizes. Support (if any) 5T32HL00795320;K24AG055602