In recent decades, China has experienced substantial climate change and significant vegetation greenness due to the extensive implementation of artificial ecological restoration programs. However, the quantitative contributions of climatic and anthropogenic drivers to the national variations in associated evapotranspiration (ET) and gross primary productivity (GPP) over China at different climate zoning sub-regions remain unclear. Based on the analysis of climate factor and vegetation disturbance trends created by anthropogenic activities, this study constructed a remote sensing-based ecological model consisting of Penman–Monteith–Leuning (PML) and light use efficiency (LUE) components. The proposed model simulated the spatiotemporal changes in ET and GPP between 1999 and 2018 over China. The contributions of climatic factors and anthropogenic activities to ET and GPP variations were quantitatively calculated by ridge regression. The results show that (1) both interannual ET and GPP markedly increased, by 1.32 mm yr−1 and 8.01 g C m−2 yr−1, respectively; (2) vegetation changes due to anthropogenic disturbance made the dominant contribution to GPP variations over China, while the dominant factor influencing ET changes differed by sub-region due to the joint effects of vegetation and climate; (3) temperature and precipitation positively affected ET, while wind speed, humidity, and solar radiation negatively contributed to ET in most parts of Mainland China. These findings may provide a workable, scientific reference for further ecological restoration decision-making processes in China.