The development of medicines, state and federal laws requiring the enrollment and mainstreaming of handicapped students and the use of behavior modifying drugs has resulted in more requests by parents to have medication administered to their children during school hours. The problem in schools without immediate access to nurses is to accommodate students who need medication while at the same time avoid the dangers that are inherent in administering medication to children. The purpose of this investigation was to determine what guidelines are being followed in Ohio schools on the storage and administration of prescribed medication. Policies and regulations on the administration of medication, solicited from a random sample of Ohio school districts, were found to be not in keeping with pertinent legislation, litigation and recommended procedures. The investigation of the sample districts revealed enough inadequacies to suggest that: 1) many Ohio school districts need formal policies and regulations in the administration of medication; and 2) Ohio school districts having policies and regulations in the administration of medication should seriously consider eliminating whatever inadequacies exist for the safety and well-being of students and staff. A sample board policy statement, regulations for administering prescription and nonprescription medication in schools, a request form and a model statute designed to protect the employee from tort liability as a result of ordinary negligence in the administration of medication were developed in keeping with the findings of this study and are recommended for consideration as models by school districts nationwide.