Introduction:Coronary artery disease (CAD) is the leading cause of death for both men and women all over the world. Lack of awareness is one of the barriers in prevention of disease. The present study evaluated the effectiveness of a video-based lifestyle modication programme on knowledge, lifestyle practices and modiable risk factors of coronary artery disease among middle aged women. Objectives: The objective of the study was to assess the effectiveness of life-style modication programme on knowledge, life style practices and modiable risk factors of coronary artery disease. Methodology: An experimental study was conducted among middle aged women living in two Grama Panchayaths in Ernakulam district of Kerala. House to house survey was conducted and those who had at least two modiable risk factors of CAD were recruited. Knowledge and lifestyle practices were assessed. Bio physical, bio physiological and biochemical measurements were done to identify risk factors of CAD. Lifestyle modication programme was given individually. Post test was conducted after 90 days of intervention. Results: The intervention was effective in modifying knowledge (p=0.01) and lifestyle practice scores (p=0.000) Systolic Blood Pressure (SBP) (p=0.000), Diastolic Blood Pressure (DBP) (p=0.000), Fasting Blood Sugar (FBS) (p=0.001), physical activity scores and dietary practice scores (p<0.000) between control and experimental groups after the intervention. Conclusion: The results suggest that administering video-based lifestyle modication programme was found to be effective in improving knowledge, lifestyle practices and some of the modiable risk factors of coronary artery disease among women.