Morphology Distribution Research Articles

Deposition and Characterization of Fluoropolymer–Ceramic (ECTFE/Al2O3) Coatings via Atmospheric Plasma Spraying

Thermal spray techniques allow coatings to be deposited from a wide range of materials with controlled thicknesses, from micrometres to millimetres. For this reason, thermal spraying can optimize performance for diverse applications across industries, ensuring strong adhesion and the durability of coated surfaces. In this work, composite ethylene chlorotrifluoroethylene/ceramic (ECTFE/Al2O3) coatings with different ceramic ratios were deposited by plasma spraying. Four coatings were produced by spraying blended powders consisting of pure ECTFE and ECTFE with 5%, 10%, and 15 wt.% Al2O3. The effect of varying the ceramic ratio on the coatings’ microstructure and properties was investigated. Morphology and particle size distributions were determined for the raw powders. The microstructural examination of the coatings showed proportional increases in Al2O3 content. An improvement in adhesion was achieved with ceramic in the coatings from 5 wt.% Al2O3. Enhanced friction coefficients were obtained with ceramic, except for 15 wt.% Al2O3. Taber abrasion tests showed a minimal influence on ceramic content.

Integrated Lithium-Rich yLi2MnO3∙(1-y)LiNi1/3Co1/3Mn1/3O2 Layered Cathode Nanomaterials for Lithium-ion Batteries

Integrated Li- and Mn-rich layered cathodes yLi2MnO3∙(1-y)LiMO2 (M = Mn, Co, and Ni) have shown their ability to deliver specific capacities close to 300 mAh g−1, but their significant drawbacks are capacity fading and voltage decay during cycling. In this study, new stoichiometric high-voltage Li-rich oxides with y = 0.0, 0.3, and 0.5 are synthesized in identical conditions using a sol–gel method. These compositions were analyzed to determine their optimal configuration and to understand their extraordinary behavior. Their nanostructural properties were investigated using XRD and Raman spectroscopy, while the morphology and grain-size distribution of the samples were characterized by BET, SEM and HRTEM analyses. The electrochemical performances of the integrated Li- and Mn-rich compounds were evaluated through galvanostatic cycling and electrochemical impedance spectroscopy. The best cathode material 0.5Li2MnO3∙0.5LiNi1/3Co1/3Mn1/3O2 had a capacity retention of 83.6% after 100 cycles in the potential range 2.0–4.8 V vs. Li+/Li.

Evaluating Swellable Cross-Linked Biopolymer Impact on Ink Rheology and Mechanical Properties of Drug-Contained 3D-Printed Thin Film

Background/Objectives: Interest in 3D printing oral thin films (OTFs) has increased substantially. The challenge of 3D printing is film printability, which is strongly affected by the rheological properties of the ink and having suitable mechanical properties. This research assesses the suitability of sodium starch glycolate (SSG), a swellable cross-linked biopolymer, on ink rheology and the film’s mechanical properties. Methods: A water-based ink comprising sodium alginate (SA), the drug fenofibrate (FNB), SSG, glycerin, and polyvinylpyrrolidone (PVP) was formulated, and its rheology was assessed through flow, amplitude sweeps, and thixotropy tests. Films (10 mm × 15 mm × 0.35 mm) were 3D-printed using a 410 µm nozzle, 50% infill density, 60 kPa pressure, and 10 mm/s speed, with mechanical properties (Young’s modulus, tensile strength, and elongation at break) analyzed using a TA-XT Plus C texture analyzer. Results: The rheology showed SSG-based ink has suitable properties (shear-thinning behavior, high viscosity, higher modulus, and quick recovery) for 3D printing. SSG enhanced the rheology (viscosity and modulus) of ink but not the mechanical properties of film. XRD and DSC confirmed preserved FNB crystallinity without polymorphic changes. SEM images showed surface morphology and particle distribution across the film. The film demonstrated a drug loading of 44.28% (RSD 5.62%) and a dissolution rate of ~77% within 30 min. Conclusions: SSG improves ink rheology, makes it compatible with 3D printing, and enhances drug dissolution (formulation F-5). Plasticizer glycerin is essential with SSG to achieve the film’s required mechanical properties. The study confirms SSG’s suitability for 3D printing of OTFs.

The sedimentation probability model based on the particle size distribution and cake morphology in the cross-flow membrane process

Evolution of non-uniform cake structure in the cross-flow membrane process was investigated in this study. Considering the real cake surface morphology and particle size distribution, the sedimentation probability of foulant (γ) was calculated, then a new flux prediction model based on the mass conservation on the cake surface was proposed. Results showed that the predictions of the new model had excellent agreements with experimental data (R2 > 0.97), wherein cake surface heights obeyed normal distribution and protrusion heights approximately obeyed exponential distribution. Meanwhile, γ decreased with cross-flow velocity from 4.59 % (0.24 m/s) to 2.53 % (0.48 m/s), whereas γ increased with trans-membrane pressure from 2.80 % (0.1 MPa) to 6.44 % (0.2 MPa). In addition, a skin layer which was approximately about 20 % of total cake thickness but possessed 70 % of the total resistance, was also observed in the cross-flow mode. These results provided a brand-new perspective (tuning cake morphology or structure) on the essence of membrane fouling alleviation.

Low resistivity achieved through enhanced sintering activity in silver paste with submicron particles created through nanoparticle self-assembly

Silver powder’s size and dispersion affect the performance of conductive silver paste. Micron-sized silver powder has good dispersibility but poor sintering activity at low temperatures. In contrast, silver nano-powder sinters at low temperatures but tends to agglomerate. To address the aforementioned issues, this paper employs a chemical reduction method to prepare high-sintering-activity submicron spherical silver powder with a large number of nanoscale bumps on its surface. The study investigates the effects of various factors on the surface morphology and particle size distribution of the silver powder, including the amount of citric acid added, the speed of the reducing agent’s addition, the pH value, and the temperature of the reaction solutions. In addition, silver pastes with varying silver powder contents (60, 70, 80, and 85 wt. %) were prepared to test their resistivity. The results indicate that the lowest resistivity of 8.9 × 10−6 Ω cm was achieved when the silver powder content was 85 wt. % and the conductive silver paste was sintered at 250 °C for 30 min. Furthermore, the prepared conductive silver pastes maintained good resistivity even when sintered at low temperatures.

A self-designed pyrolysis-gasification-combustion pilot plant for rural solid waste disposal: The elucidation of emission factors

The research group developed a pyrolysis-gasification-combustion pilot plant (PGCP) to treat rural solid waste (RSW). Based on the study of previous operating conditions, this study further explored the characteristics of potential secondary pollutants in the plant, such as slag, fly ash and flue gas. In the present study, X-ray fluorescence (XRF), X-ray diffraction (XRD) and scanning electron microscope (SEM) were used to analyze slag and fly ash. Besides, the leaching toxicity, content and morphology distribution of heavy metals (e.g., Cu, Pb, Cd, Zn and Cr) in the slag of PGCP were also studied as well as the emission characteristics of various pollutants in flue gas. Results show that slag mainly contains CaCO3 and SiO2, while CaCO3 is mainly contained in fly ash. Moreover, the leaching toxicity of heavy metals in the slag did not exceed the limit value of the standard in China. The present study could provide technical support and data for optimizing the operation of plant-scale pyrolysis of RSW.

Porosity Analysis of Acacia catechu Seed-derived Carbon Materials Activated with Sodium Hydroxide and Potassium Hydroxide: Insights from Methylene Blue and Iodine Number Methods

The significant adsorption capacity of activated carbon makes it a highly effective adsorbent material. The choice of activating chemicals plays a crucial role in determining the surface morphology and pore size distribution of the resulting activated carbon. In this study, potassium hydroxide and sodium hydroxide were employed as chemical activating agents in the preparation of activated carbon from the waste biomass of Acacia catechu seeds through a carbonization process. Fourier-transform infrared spectroscopy (FTIR) was utilized to examine the surface functional groups, while X-ray diffraction (XRD) analysis provided insights into the crystallinity of the activated carbons. Field-Emission Scanning Electron Microscopy (FESEM) was employed to analyze surface morphology. For the adsorption capacity assessment, methylene blue number (MBN) and iodine number (IN) method were employed. The activated carbon derived using KOH-activator (ACSK-6) exhibited higher iodine number (1269.62 mg/g) and methylene blue number (238.62 mg/g) compared to activated carbon synthesized using NaOH (ACSN-6). The well-developed porosity and superior adsorption capacity of the ACSK-6 sample underscore its potential in various application.

Seasonal morphological changes and grain size distribution mapping on the Massa beaches using a tachometer and GIS

Sandy beaches are complex, highly dynamic, fragile environments that are constantly evolving. Understanding the dynamics of these areas is crucial, both for fundamental science and for coastal zone management. This study presents the results of a seasonal morphological and sedimentological monitoring of the sandy beaches of Massa, located in the central-western region of Morocco. This monitoring was conducted using both an electronic total station and the spatialization of grain size indices (median, sorting index So, and skewness) through interpolation within a Geographic Information System (GIS). A total of 15 topographic profiles were surveyed perpendicular to the coastline during three field campaigns conducted between September 2019 and July 2020. The results indicate a morphodynamic equilibrium of the beaches, characterized by a normal morphological cycle with erosion during winter and accretion during summer. This balance is primarily attributed to the physical behavior of the beaches in response to wave energy, as well as the presence of a highly developed coastal dune capable of supplying sediment to the beaches during periods of shortage. Additionally, the spatialization of grain size indices from 90 samples clearly highlights the significance of hydrodynamic factors, such as waves, tides, currents, littoral drift, and winds, in the distribution of sandy sediments on the Massa beaches. Atlantic waves from the NNW sector, accompanied by a North-South littoral drift, govern the transport and deposition of sediments along beaches, while tides, currents, and local winds contribute to their redistribution across the different beach zones (foreshore, backshore, and coastal dune). Indeed, seasonal hydrodynamic conditions, as well as the proximity or distance of sediment source zones, play a critical role in sediment distribution along these beaches, providing valuable insights for coastal management strategies aimed at mitigating erosion, preserving beach morphology, and ensuring sustainable development in coastal zones.

Automatic segmentation of cortical bone microstructure: Application and analysis of three proximal femur sites.

Osteoporosis is the most common bone metabolic unbalance, leading to fragility fractures, which are known to be associated with structural changes in the bone. Cortical bone accounts for 80 % of the skeleton mass and undergoes remodeling throughout life, leading to changes in its thickness and microstructure. Although many studies quantified the different cortical bone structures using CT techniques (3D), they are often realised on a small number of samples. Therefore, the work presented here proposes a method to quantify cortical bone microstructure using 2D histology, shows its application on a set of 94 samples and compares to 3D methods. Fresh frozen human femur pairs from 47 donors aged between 57 and 96 years were obtained from the Medical University of Vienna. Bone samples were cut from 3 sites: proximal part of the diaphysis, inferior and superior segments of the neck. The samples were stained with toluidine blue and imaged under light microscopy. After manual segmentation of a few regions of interest by multiple operators, a convolutional neural network was trained in combination with a random forest for automatic segmentation. The segmentation analysis compares morphology and structure distribution of Haversian canals, osteocyte lacunae, and cement lines with literature, between anatomical sites, sex, left and right sides, and relation to ageing. Morphological analysis of the segmentation gives results similar to the literature. Comparison between male and female donors shows no significant differences. There is no significant difference between left and right femur on paired samples but significant differences are observed between anatomical locations. The structures' relative amounts do not present significant changes with age but only weak tendencies. Nevertheless, a strong correlation was observed between osteocyte lacunae density and bone areal fraction. This study presents a full process to stain and automatically segment digital cortical bone images. Its application to a large sample set of proximal femora provides strong statistics on the cortical bone structures morphology and distribution. Similarities observed between sides and sexes together with differences observed between sites could indicate that mechanical loading might be a main driver for bone microstructure. Additionally, the relationship between osteocyte lacunae density and bone areal fraction could suggest that bone porosity is regulated by osteocyte survival.

Effect of Biochar-Based Organic Fertilizers on the Transport and Accumulation of Heavy Metals in Soil and Plants

Anaerobically digested digestate is mostly used as organic fertilizer, but there is still a potential risk of heavy metal pollution. Biochar and bio-organic fertilizer through passivation can effectively reduce the mobility of heavy metal ions in soil, with the strong adsorption capacity of heavy metals, and are widely used in soil remediation. In this study, digestate as raw material supplemented with biochar was applied to simulated heavy metal-contaminated soil, and its effects on heavy metal content and the transformation of forms in soil and crop systems were systematically investigated. The application of biochar-based organic fertilizer to simulated heavy metal-contaminated soils resulted in large differences in the morphological distribution of heavy metals, which was reflected in a significant decrease in the content of heavy metals in the weakly acid-extractable state and an increase in the content of heavy metals in the residue state, and promoted the transformation of soil heavy metals from the weakly acid-extractable state to the residue state. There were differences in the accumulation of heavy metals in the above ground and below ground parts of cabbage, and Cu, Zn, Cd, and Pb were mainly accumulated in the below ground parts of the plants. The present study offers an effective methodology for the remediation of soil and plant contamination by a range of heavy metals (Cu, Zn, Cd, and Pb), from the weak acid extraction stage to the residue stage. This approach is of particular significance for the advancement of sustainable agriculture and environmental remediation.

Acorusshannai (Acoraceae), a new species from Southern China.

Acorusshannai (Acoraceae) is a commonly used seasoning in southern China. It was previously misidentified as A.macrospadiceus (Yamam.) F. N. Wei & Y. K. Li before. Through comparison of morphological characteristics, distribution locations, and type specimen, we determined that the elevation of A.gramineusvar.macrospadiceus Yamam to species status was incorrect. Therefore, we propose a formal description of a new species following nomenclature regulations. Based on morphological and plastid genomic data, this study formally describes and illustrates Acorusshannai, distributed in the Qiandongnan area of Guizhou Province and its surroundings, confirming it as a new species within the genus Acorus. This species is morphologically and phylogenetically distinct from other members of the A.gramineus group. Key distinguishing features include a strong fennel odor (vs. aromatic in "A.tatarinowii" and A.gramineus), fruit with prominent dorsal sutures (vs. inconspicuous dorsal sutures in "A.tatarinowii" and A.gramineus), and a leaf-shaped spathe that is about 2-3 times as long as the spadix (vs. more than 3 times in "A.tatarinowii"). Phylogenetic analysis showed that A.shannai is closely related to the other species in the A.gramineus group. The recognition of A.shannai is not only important for the species diversity and phylogenetic relationship of Acorus, but also can avoid the drug safety caused by using other Acorus species as A.shannai to eat and promote the conservation of A.shannai resources.

Insights on the evolution and adaptation toward high-altitude and cold environments in the snow leopard lineage.

How snow leopard gradually adapted to the extreme environments in Tibet remains unexplored due to the scanty fossil record in Tibet. Here, we recognize five valid outside-Tibet records of the snow leopard lineage. Our results suggest that the snow leopard dispersed out of the Tibetan Plateau multiple times during the Quaternary. The osteological anatomy of the modern snow leopard shows adaptation to the steep slope and, to a lesser extent, cold/high-altitude environment. Fossils and phylogeny suggest that the snow leopard experienced a gradual strengthening of such adaptation, especially since the Middle Pleistocene (~0.8 million years). Species distribution modeling suggests that the locations of the fossil sites are not within most suitable area, and we argue that local landscape features are more influential factors than temperature and altitude alone. Our study underscores the importance of integrating morphology, fossil records, and species distribution modeling, to comprehensively understand the evolution, ecology, and inform conservation strategies for endangered species.

Macro-Micro Mechanics of Granular Soils Under Shear Considering Coupled Effects of Particle Size Distribution and Particle Morphology.

This paper investigates the effects of particle morphology (PM) and particle size distribution (PSD) on the micro-macro mechanical behaviours of granular soils through a novel X-ray micro-computed tomography (μCT)-based discrete element method (DEM) technique. This technique contains the grain-scale property extraction by the X-ray μCT, DEM parameter calibration by the one-to-one mapping technique, and the massive derivative DEM simulations. In total, 25 DEM samples were generated with a consideration of six PSDs and four PMs. The effects of PSD and PM on the micro-macro mechanical behaviours were carefully investigated, and the coupled effects were highlighted. It is found that (a) PM plays a significant role in the micro-macro mechanical responses of granular soils under triaxial shear; (b) the PSD uniformity can enhance the particle morphology effect in dictating the peak deviatoric stress, maximum volumetric strain, contact-based coordination number, fabric evolution, and shear band formation, while showing limited influences in the maximum dilation angle and particle-based coordination number; (c) with the same PSD uniformity and PM degree, the mean particle volume shows minimal effects on the macro-micro mechanical behaviours of granular soils as well as the particle morphology effects.

Unveiling Microscopic Variations during Photodynamic Therapy via Polarity-Responsive Fluorescence Lifetime Imaging.

Photodynamic therapy is a highly promising method for cancer adjuvant treatment. However, the current research on the microscopic changes during the photodynamic therapy process is still quite limited, which seriously impedes the deep understanding of the procedure. For this purpose, a novel polarity-responsive probe, MI-PPF, with excellent mitochondrial targeting and anchoring capabilities has been rationally designed and synthesized. Notably, MI-PPF has successfully realized the in situ detection of mitochondrial morphology and polarity alterations during the photodynamic therapy process in cancer cells through fluorescence lifetime imaging. The results showed that a series of phenomena such as deformation, shrinkage, vacuolation, and aggregation occurred in the mitochondrial morphology during photodynamic therapy. Concurrently, a decline in mitochondrial polarity is also noted, which may be closely linked to the mitochondrial oxidative stress response during this process. Furthermore, MI-PPF can be used for photodynamic therapy on tumor mouse models and has successfully achieved fluorescence lifetime imaging of tumor sections before and after photodynamic therapy, uncovering multifaceted changes in cell morphology, polarity, and polarity distribution within the mouse tumor model during the process. It is anticipated that this study will offer valuable insights and guidance to the research of mitochondrial-related fields and will boost the advancement of diagnostic and therapeutic areas for associated diseases.

Paepalanthus roqueae: a new critically endangered Eriocaulaceae in campo rupestre of Chapada Diamantina, Bahia, Brazil

Here we describe a new species of Paepalanthus (Eriocaulaceae) from the Chapada Diamantina, in the northern part of the Espinhaço range in Brazil. The study aims to contribute to the knowledge of Eriocaulaceae in this area, which has a significant knowledge gap, and to provide a comparison with other poorly understood species in the region. The new species, named Paepalanthus roqueae, is described in detail, including morphological measurements, illustrations, and distribution maps. Its conservation status is also evaluated using IUCN criteria. This paper emphasizes the importance of botanical research in the high biodiversity area of Chapada Diamantina, to increase the knowledge of poorly understood species and promote conservation efforts.

Comparison of different fixatives effects in histochemical stainings of peripheral nerve tissue.

A pathological condition in the peripheral nerve tissue, which provides the connection between the organism and the external environment, negatively affects the standard of living. The nerve tissue histotechnology is of serious importance both for scientific studies and for clinical diagnosis. The fixation, which is one of the leading procedures for histological examination of tissues, aims to preserve tissue morphology. Another essential part of the histological examination is staining process. This study, it was aimed to determine the fixative that provides optimal histological appearance in peripheral nerve tissue. Therefore, various histochemical stainings of tissues fixed with some fixatives used in practice were compared. Sciatic nerves from each rat (n=7) used in the study were fixed with different fixatives and histochemical staining was performed. In histological examination, cellular (nucleus-cytoplasm) and intercellular morphological details, staining intensity and distribution were evaluated. At the end of the study, formaldehyde was found to be the most ideal fixing agent for all stains. Although Bouin and Carnoy fixatives differed according to the staining type, their fixation quality was similar in general. Glutaraldehyde did not give as good results as other fixatives in all stainings. This study is an important technical reference for clinical and experimental studies.

Removal of Tetracycline Antibiotic as a Hospital Waste by pH‐Sensitive Degradable Composite Hydrogel Using Fenton‐Like System

ABSTRACTFenton‐like hydrogels crosslinked with imine bond were prepared for the removal of tetracycline. Initially, the oxidation process of carboxymethyl cellulose (CMC) was performed, and it was named OX‐CMC. The confirmations were then obtained using NMR and FTIR analyses. The degree of CMC oxidation was investigated in relation to reaction time, and optimal time of 4 h was selected. In the second part, a pH‐sensitive hydrogel with imine bond was prepared from the crosslinking reaction between OX‐CMC and chitosan. The formation of the hydrogel through imine crosslinking was confirmed by FTIR spectroscopy. By increasing ratio of OX‐CMC to chitosan, the swelling rate for the hydrogel decreased. Turbidity measurements showed that a higher OX‐CMC to chitosan weight ratio resulted in slower hydrogel degradation in acidic environments. In the third part, Fe3O4 nanoparticles with concentrations of 5 and 10 wt% were incorporated into the hydrogel structure. TEM studies revealed a spherical morphology and uniform distribution of nanoparticles within the hydrogel network. SEM images revealed a porous structure which composed of interconnected pores in the hydrogel. The results of UV–visible spectroscopy indicated that the degradation of magnetic hydrogels would augment as magnetic nanoparticle content increases, pH decreases, and the hydrogen peroxide content increases.

Development and Characterization of Hyaluronic Acid Graft-Modified Polydopamine Nanoparticles for Antibacterial Studies.

The problem of antibiotic abuse and drug resistance is becoming increasingly serious. In recent years, polydopamine (PDA) nanoparticles have been recognized as a potential antimicrobial material for photothermal therapy (PTT) due to their excellent photothermal conversion efficiency and unique antimicrobial ability. PDA is capable of rapidly converting light energy into heat energy under near-infrared (NIR) light irradiation to kill bacteria efficiently. In order to solve the problem of PDA's tendency to aggregate and precipitate, this study improved its stability by grafting hyaluronic acid (HA) onto the surface of PDA. Using dopamine and hyaluronic acid as raw materials, hyaluronic acid (HA) was grafted onto polydopamine (PDA) nanoparticles via self-polymerization and Michael addition reactions under alkaline conditions to obtain PDA-HA-modified nanoparticles. We confirmed the successful grafting of hyaluronic acid via scanning electron microscopy (SEM), Fourier infrared spectroscopy (FTIR), nuclear magnetic hydrogen spectroscopy (¹H NMR), ultraviolet-visible spectroscopy (UV-vis), Raman spectroscopy (Raman), and dynamic light scattering (DLS) methods. Scanning electron microscopy (SEM) was used to observe the surface morphology and nanostructure of the grafted materials, providing information on the morphology and size distribution of the materials. Near-infrared performance experiments showed that the temperature of the PDA-HA solution increased rapidly under near-infrared light irradiation, demonstrating an excellent photothermal conversion performance. Antimicrobial properties were assessed via the colony counting method, and typical Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli were selected as model strains. The experimental groups were tested under dark conditions and near-infrared (NIR) light irradiation. PDA/HA showed significant photothermal properties under NIR light irradiation, resulting in a rapid increase in the surrounding temperature to a level sufficient to kill bacteria. Under NIR light irradiation, PDA/HA exhibited 100% antimicrobial efficacy against both S. aureus and E. coli, while antimicrobial efficacy was limited under dark conditions. This indicates that the antibacterial activity of PDA/HA is highly dependent on NIR light activation.

Exploring the potential of gemcitabine-metal–organic frameworks in combating pancreatic cancer under ketogenic conditions

BackgroundInadequate treatment responses, chemotherapy resistance, significant heterogeneity, and lengthy treatment durations create an urgent need for new pancreatic cancer therapies. This study aims to investigate the effectiveness of gemcitabine-loaded nanoparticles enclosed in an organo-metallic framework under ketogenic conditions in inhibiting the growth of MIA-PaCa-2 cells.MethodsGemcitabine was encapsulated in Metal–organic frameworks (MOFs) and its morphology and size distribution were examined using transmission electron microscopy (TEM) and Dynamic light scattering (DLS) with further characterization including FTIR analysis. Various drug groups were established to evaluate their influences on cell cytotoxicity, apoptosis rate, cell cycle distribution, levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), and cell migration.ResultsThe gemcitabine-MOF was thoroughly analyzed to determine its size, morphology, and chemical composition, confirming its successful preparation. The treatment results showed an increase in the number of apoptotic cells following gemcitabine-MOF treatment, which was found to be associated with cell cycle arrest in the sub-G1 phase. Moreover, these treatments also resulted in reduced cell migration, decreased activity of antioxidant enzymes (SOD, GPx), and increased accumulation of MDA. Additionally, when exposed to ketogenic conditions (where beta-hydroxybutyrate is present in a glucose-limited medium), there was a further increase in cell cycle arrest, accompanied by a more pronounced decrease in SOD and GPx activity, as well as decreased migration.ConclusionThe use of metal–organic framework to encapsulate gemcitabine yielded notable pro-apoptotic effects in MIA-PaCa-2 cells with which ketogenic conditions had a synergistic effect that can hold promise for improving therapeutic options.Graphical

Study of residual stress and residual deformation of T-joints by continuous simultaneous double-sided welding

This paper investigates both the magnitude and distribution of temperature field, residual stress and deformation of DH36 steel fillet welded T-joints through the numerical simulation method. A thermal elastic-plastic finite element analysis is performed to investigate the heat transfer and deformation mechanisms during the welding process, employing a DFLUX subroutine developed in ABAQUS based on the double-ellipsoidal heat source model. The effects of welding speed and power on residual stress and deformation are further investigated. The finite element simulation results show good agreement with experimental measures regarding temperature distribution, melt pool morphology, residual stress, and deformation distribution. The results show that welding speed and power significantly affected the temperature variation during the welding process, which further influence the distribution of residual stress and residual deformation. The results indicate that high power at low welding speeds producing high temperatures leads to bottom fusion, while low power at high welding speeds resulted in insufficient fusion depth. Therefore, selecting appropriate welding speed and power is crucial for ensuring weld quality.