Distribution Of Hemoglobin Variants Research Articles

Differences in the distribution of hemoglobin variants according to the geographic regions in a Colombian population

Colombia has been subject to intense genetic and cultural currents due to its geographical location. Hemoglobinopathies are the most common recessive diseases found worldwide and represent an important public health problem, according to the region and ancestry of each country. To evaluate the frequency of hemoglobin variants according to the geographical region in a population group adjusted to sex and age in Colombia. This was a descriptive retrospective study of hemoglobin variants performed by electrophoresis in patients treated at and/or referred to specialized care institutions in Bogota, Colombia between January 2009 and December 2020. A total of 2,224 results were analyzed, 48.4% male and 51.5% female; 63.3% of patients were without alterations, 14.3% presented with thalassemia, 17.3%, HbS, 2.3%, HbS/C, 1.8%, HbC, 0.5%, HbE and 0.5% persistent HbF, with HbS being more prevalent in males (p=0.005). When assessing the geographical regions of Colombia, a higher prevalence of HbS was found in the Pacific (p=0.005) and Caribbean regions, while Thalassemia and HbS were more prevalent in the Andean and Orinoquia regions, and it was rare to find any hemoglobinopathies (p=0.0001) in the Amazonian region. The main hemoglobinopathies found in Colombia are HbS, predominantly in males, and Thalassemia. The distribution of hemoglobinopathies in different geographical regions of Colombia is influenced by ancestry.

Distribution of haemoglobin variants, ABO blood group and Rhesus D among nursing students of Madonna university Nigeria

Distribution of haemoglobin variants, ABO blood group and Rhesus D among nursing students of Madonna university Nigeria

Prevalence of haemoglobin variants among the Ika ethnic nationality of Delta state

Background : Haemoglobin genotype is an important blood component that determines haemoglobinopathies. Distribution of haemoglobin variants was investigated among the Ika ethnic nationality of Delta State, Nigeria. Aim: The resent study was conducted to determine the prevalence of haemoglobin variants and also to provide information for instituting genetic counseling services to reduce haemoglobinopathies between couples. Methods : A total of 600 subjects were screened for haemoglobin genotypes using paper electrophoresis. Results : The prevalence of HbAA, HbAS, HbAC and HbSS were 78%, 19.5%, 0.5% and 2% respectively. There was no relationship (P˃0.05) between sex and haemoglobin variants. There was a low prevalence of abnormal haemoglobin variants observed which is consistent with previous studies. Conclusion : The sickle cell trait (HbAS) is the largest variant in this population; we therefore advocate mandatory haemglobin genotype screening for all intending couples in order to reduce the sickling gene pool. Keywords : Haemoglobin variant; haemoglobinopathies; prevalence; genotype; deoxyribonucleic acid; electrophoresis

Frequency distribution of hemoglobin variants among Yorubas in Ibadan, south western Nigeria: A pilot study

Background: Inherited disorders of hemoglobin are the most common gene disorders worldwide. The objective of this study is to determine the frequency distribution of hemoglobin variants among the Yorubas residing in Ibadan. Materials and Methods: Five hundred and thirty one subjects comprising 184 males and 347 females, of age 1-70 years, were enrolled in the study. Ethical approval was obtained from the Ethical Committee of the University College Hospital and a duly signed informed consent was obtained from each subject. Two milliliters of venous blood was aseptically collected from each participant for the determination of hemoglobin genotype, using the standard hematology method. Results: Hemoglobin HbAA recorded the highest frequency distribution (65.3%). This was followed by hemoglobin variant HbAS (24.1%), abnormal hemoglobin variant HbSS (5.5%), HbAC (4%), and HbSC (1.1%), (P > 0.05). The female subjects revealed higher frequency distributions of AA, AS, SS, and SC, while the male demonstrated higher frequencies in AC and SC only. Conclusion: It can be concluded that the Yoruba indigenes residing in Ibadan have a high frequency distribution of HbAA and a future reduction in the HbSS disease in the populace is possible.

Molecular basis and hematological features of hemoglobin variants in Southern Thailand

Hemoglobinopathy (abnormal hemoglobin or hemoglobin variant) is an inherited disorder that results in the abnormal structure of globin chains of the hemoglobin (Hb) molecule. Many abnormal Hbs have been characterized worldwide, including more than 20 variants in Thailand. The Bio-Rad Variant II HPLC system is used for investigating hemoglobin variants at Songklanagarind Hospital. This system has been shown to be a sensitive, specific, and reproducible method, but some hemoglobin variants such as Hb Tak and Hb D-Punjab cannot, as yet, be clearly separated by this method. The aim of this study was to investigate the prevalence of hemoglobinopathy in southern Thailand using DNA sequencing and study the severity of each hemoglobin variant. A total of 58 hemoglobin variant samples were obtained from blood samples undergoing routine hemoglobin typing at Songklanagarind Hospital. Genomic DNAs were extracted from the samples, and the globin genes were analyzed by using PCR-direct sequencing. The molecular analysis revealed eight hemoglobin variants: 28 Hb C, 12 Hb D-Punjab, 7 Hb Tak, 4 Hb G-Makassar, 2 Hb Lepore-Hollandia, 2 Hb Q-Thailand, 2 Hb O-Indonesia, and 1 Hb Hope. The distribution of hemoglobin variants in southern Thailand is associated with geographic and/or ethnic backgrounds. This study may help hematologists understand better the prevalence of hemoglobin variants and their hematological features in this region.