Microgreens have a high nutrient density and are beneficial to human health. Even though this class of vegetables have gaining increasing levels of attention in the last year, scientific research on the growth of microgreens in controlled environments under artificial lighting have not been thoroughly characterized. By describing the scientific outputs focused on the impacts of artificial illumination on microgreens, especially from the first two decades of the 21st century, it is therefore possible to detect advancements and research gaps in this research field. This review is divided in two parts: first, a general overview of the scientific production about microgreens; second, a systematic review of scientific studies exploring artificial lighting on the production of microgreens. The overview of scientific production on microgreens and artificial lighting across the Scopus, Web of Science, and Scielo databases, from 2000 to 2021, respectively, indicated three phases, as before 2011 no paper was found: phase 1 (2012 to 2014), six papers; phase 2 (2015 to 2018), fifteen papers; and phase 3 (2019 to 2021), forty-six papers, respectively. Mustard was the most evaluated crop under all production stages. With regard to the second part of this review, studies on artificial lighting with fluorescent lamps (high-pressure sodium light bulbs—HPS), from the supplementation to the replacement of HPS lighting with light emitting diode (LED) lamps, and plant responses with respect to light properties comprise the main works identified. Studies on the distribution of environmental factors under controlled microgreen cultivation present research gaps.