<h3>Purpose</h3> Severe complications after left ventricular assist device (LVAD) placement remain a major issue. Socioeconomic markers have been examined as risk factors for immediate post-operative complications and short term (within 90 days) readmissions; however, the total burden of re-hospitalizations and whether primary causes and frequency of severe complications differ by sociodemographic factors has not been well described. <h3>Methods</h3> Using hospitalization data from the Healthcare Cost and Utilization Project: National Inpatient Sample, we identified all hospitalizations between 2012 and 2016 of adults ≥18 years old with history of prior LVAD placement. Primary causes for hospitalization were categorized initially into 15 groups and then presented in 7 groups (Figure 1). Distribution of primary causes were assessed in subgroups of age (18-44, 45-64, ≥65), sex, and race. Differences within subgroups were assessed by chi-squared statistics. <h3>Results</h3> We identified 48,405 hospitalizations during the 5-year study period (41% age ≥65, 77% male, 25% Black, 58% White, 5% Hispanic). Infection was the most frequent primary cause in younger adults (age 18-44) (Figure 1). GI bleed was the most common cause in adults ≥65 (18.2% of hospitalizations) but less frequent in younger adults (ages 18-44: 3.7% and 45-64: 13.7%, X<sup>2</sup> p=<0.001). Device complications occurred most frequently in younger adults (ages 18-44: 6.4%, 45-64: 4.4%, and ≥65: 3.7%, p=<0.001). Frequencies of hospitalizations were similar by sex. Hispanics had the highest frequency of heart failure (16.0%) which differed from Blacks (14.7%) and Whites (13.0%) (p=<0.001). <h3>Conclusion</h3> Significant demographic differences exist in frequency of primary causes of hospitalization in adults with prior LVAD placement. Future study is necessary to understand how distribution of causes vary by socioeconomic differences after adjusting for demographic and clinical characteristics during long term follow-up.