A numerical simulation of steam condensation containing non-condensable gas is conducted in this paper to analyze the heat and mass transfer characteristics in vertical corrugated tube. The species transport model, Euler liquid film model and diffusion-balance model with Dehbi factor to correct the diffusion effect are applied to simulate the mass and energy transfer processes. The effects of different corrugated tube structural parameters and inlet steam parameters on steam condensation rate, liquid film distribution and heat transfer are simulated. The results show that vortex and accumulated non-condensable gas in the corrugated region significantly influence condensation heat transfer, which are closely related to corrugation height (H=0–5 mm) and corrugation length (L=13, 16, 19, 22, and 25 mm) of the corrugations, as well as inlet velocity (Vin = 5, 7, 9, 11, 13, and 15 m·s−1) and inlet steam content (Ws = 0.6, 0.7, 0.8, 0.9, 0.99, and 1). The total heat transfer coefficient varies linearly with inlet velocity when inlet velocity increase from 5 m·s−1 to 15 m·s−1, which increase 89.6–108.1 %; total heat transfer coefficient increases almost exponentially when inlet steam content increase from 0.6 to 1, which increase 389–460 %; and the best corrugated tubes are those with corrugation height of 0.075 times diameter of tube and corrugation length of 0.325 times diameter of tube.