Herba Polygoni Pubescentis (HPP) is a traditional Chinese herb known for its various health benefits. It has been widely applied for conditions such as rheumatism, arthritis and skin disorders thanks to its antibacterial, anti-inflammatory, anti-tumour, antioxidant, antiviral and anti-fodder properties. There is widespread growing interest to further understand HPP, the natural-based herbal remedy. Therefore, this study starts with a general introduction of HPP including its taxonomical classification, distribution and botanical characteristics etc. Through literature review, both domestic and abroad, on the past and ongoing research on the active compounds and extraction methods, this study aims to provide comprehensive information on HPP’ phytochemistry, therapeutic efficacy and pharmacological uses, as well as its applications in feed, wine making, ecological restoration and pharmaceutical applications. Thus, this study will serve as a source of theoretical basis for the various applications of HPP and shed the light on its direction of further research and development opportunities