Analysis Of Distribution Research Articles

High transmission in 120-degree sharp bends of inversion-symmetric and inversion-asymmetric photonic crystal waveguides

Bending loss is one of the serious problems for constructing nanophotonic integrated circuits. Recently, many works reported that valley photonic crystals (VPhCs) enable significantly high transmission via 120-degree sharp bends. However, it is unclear whether the high bend-transmission results directly from the valley-photonic effects, which are based on the breaking of inversion symmetry. In this study, we conduct a series of comparative numerical and experimental investigations of bend-transmission in various triangular PhCs with and without inversion symmetry and reveal that the high bend-transmission is solely determined by the domain-wall configuration and independent of the existence of the inversion symmetry. Preliminary analysis of the polarization distribution indicates that high bend-transmissions are closely related to the appearance of local topological polarization singularities near the bending section. Our work demonstrates that high transmission can be achieved in a much wider family of PhC waveguides, which may provide novel designs for low-loss nanophotonic integrated circuits with enhanced flexibility and a new understanding of the nature of valley-photonics.

Comparative analysis of stress distribution in implant attachment versus cantilever prostheses

Comparative analysis of stress distribution in implant attachment versus cantilever prostheses

Effect of different addition orders of petrochemical by-product-based mixed collectors on coal flotation

ABSTRACT An effective collector is crucial for enhancing coal flotation efficiency. The effect of a mixed collector based on petrochemical by-products on coal flotation was investigated. The investigation included various addition orders and was conducted using flotation tests, particle size distribution analysis, GC-MS, FTIR and contact angle measurements. The Mixed addition order exhibited superior performance in flotation compared to the K+Y and Y+K orders at all tested dosages. Particle size distribution analyses revealed that the mixed collector offered better dispersion in water than individual the Y-oil and K-oil, with droplet sizes below 100 µm. FTIR and contact angle measurements indicated that coal treated with the Mixed addition order demonstrated optimal reagent adsorption and the highest level of surface hydrophobicity. Aromatic compounds in the collector interacted with the hydrophobic areas of the coal surface, while partially covering some of the hydrophilic regions between these hydrophobic sites. Conversely, heteropolar components engaged with the hydrophilic regions on the coal surface to enhance adsorption. Despite these improvements, some hydrophilic sites remained after treatments with the Y+K and K+Y orders, which continued to affect the coal flotation properties.

Valorization of Bauxite Residue for Use as Adsorbent for Reactive Blue Removal: Regeneration Evaluation

In recent years, there has been increasing concern regarding the widespread occurrence of dyes in aquatic environments, due to their harmful effects on both water quality and human health. This investigation uses bauxite residue as a cost-effective sorbent to eradicate the hazardous reactive blue (RB) dye from aqueous solutions. The reusability potential of bauxite residue was also evaluated. The bauxite residue was characterized by X-ray diffraction, Cation Exchange Capacity, Chemical analysis, FTIR, and Analysis of particle size and particle distribution. The RB dye adsorption parameters revealed that the removal efficiency and adsorption capacity of bauxite residue was 100% and 186.01 mg/g, respectively, under the following adsorption conditions: adsorbent dosage of 0.5 mg/L, initial pH of 2, dye concentration of 50 mg/g, and reaction temperature of 25 °C. Furthermore, the adsorption of RB dye on bauxite residue followed the pseudo-second-order kinetic and Freundlich isotherm models. After one adsorption cycle, the adsorption capacity of bauxite residue for reactive RB removal reached 186.01 mg/g. The regeneration study revealed that the bauxite residue remained 99% of its original condition following the water regeneration cycle.

Barcoded Hybrids of Extracellular Vesicles and Lipid Nanoparticles for Multiplexed Analysis of Tissue Distribution.

Targeted delivery of therapeutic agents is a persistent challenge in modern medicine. Recent efforts in this area have highlighted the utility of extracellular vesicles (EVs) as drug carriers, given that they naturally occur in bloodstream and tissues, and can be loaded with a wide range of therapeutic molecules. However, biodistribution and tissue tropism of EVs remain difficult to study systematically.Here, a multiplexed approach is developed for simultaneous tracking of EVs from various cell lines within a single in vivo experiment. EVs are used from 16 different cell lines, and through controlled fusion with lipid nanoparticles (LNPs) carrying single-stranded DNA barcodes, uniquely barcoded hybrid EV particle (hEV) library is generated. These hEVs are combined for a multiplexed in vivo biodistribution profiling in mice, and discovered that HAP1-derived hEVs demonstrated lung tropism, suggesting that these hEVs may be used for targeted drug delivery into lung tissue. To examine this possibility further, it is shown that HAP1 hEV loaded with Cre mRNA displayed functional delivery to the lungs. Overall, the barcoded hEV technology enables rapid profiling of biodistribution across EV cell sources, which is poised to improve throughput and extent of EV studies, while reducing the number of animals required for research.

XUV yield optimization of two-color high-order harmonic generation in gases

Abstract We perform an experimental two-color high-order harmonic generation study in argon with the fundamental of an ytterbium ultrashort pulse laser and its second harmonic. The intensity of the second harmonic and its phase relative to the fundamental are varied while keeping the total intensity constant. We extract the optimum values for the relative phase and ratio of the two colors which lead to a maximum yield enhancement for each harmonic order in the extreme ultraviolet spectrum. Within the three-step model, the yield maximum can be associated with a flat electron return time versus return energy distribution. An analysis of different distributions allows to predict the required relative two-color phase and ratio for a given harmonic order, total laser intensity, fundamental wavelength, and ionization potential.

Analysis of Temperature and Stress Distribution on the Bond Properties of Hybrid Tailored Formed Components

Processing of hybrid materials is particularly challenging due to the different physical properties and requires extensive knowledge to produce defect‐free components. When serially combining steel and aluminum through rotary friction welding and subsequent cup backward extrusion in Tailored Forming, the strongly different yield stresses are a decisive factor. The following study analyzes the temperature and stress distribution after the compensatory heating step with additional cooling and during cup backward extrusion within a preform of a hybrid hollow shaft using experimental heating tests and finite element simulations. The influence on the bond strength is quantified by uniaxial tensile tests along the interface. Compared to uncooled samples, local cooled samples exhibit higher compressive stresses in the joining zone and hence higher forming resistance due to higher temperature gradients. Therefore, delamination and cracks can be prevented. While areas at the edge or in the center indicate reduced strengths overall, areas with high surface enlargement do not fail in the joining zone, but in the base material of the aluminum. To further enhance process stability and process control measures, a preliminary concept for the implicit determination of component temperatures using integrated sensor systems on the handling system is presented.

REVIEW ON SIZE EXCLUSION CHROMATOGRAPHY COUPLED WITH MASS SPECTROSCOPY

The hyphenated technique was created by integrating the differentiating technique with directly spectroscopic technology to facilitate detection. It is discussed how SEC and electrospray ionization mass spectrometry (ESI-MS) can be combined, emphasizing the advantages this has for characterizing polymers. The capacity of SEC-ESI-MS to gather polymer structural information as well as to confirm polymer homologous transitions is first described. It's significant that the broad applicability of SEC-ESI-MS is underlined, for instance by its usage in the analysis of precise molecular weight distribution of polymers, the calculation of radical rate of polymerization coefficients, and the thorough exploration of radical photoinitiation systems. Thus, this momentous tutorial review intends to highlight the high potential of SEC-ESI-MS to emerge as a formidable and well-liked analytical method in polymer chemistry and to illustrate the capability of SEC-ESI-MS for the analysis of complicated polymers. The article addresses recent advancements in the uses of a variety of hyphenated techniques, such as the GC-MS method, LC-MS analysis, LC-FTIR, LC-NMR, CE-MS, and others.

Exploring DL-2-aminobutyric acid: DFT analysis and spectroscopic characterization

DL-2-aminobutyric acid (α-aminobutyric acid), an alpha amino acid, has been extensively investigated through experimental and theoretical methods. Theoretical analyses have been carried out using density functional theory. Spectroscopic techniques such as Fourier transform infrared and UV spectroscopy have been employed, with experimental spectra aligning closely with theoretical predictions. Studies of electronic transitions between unoccupied and occupied states have been performed in solvents like dimethyl sulfoxide (DMSO) and Methanol (MeOH). The Time Dependent Density Functional Theory (TD-DFT) method and Iterative Electrostatic Potential Continuum Model (IEPCM) model assessed charge transfer in these solvents. Vibrational analysis and other studies, including Frontier Molecular Orbital (FMO), natural bond analysis, and non-linear optical analysis, were based on structures optimized using the B3LYP method with the 6-311++G(d,p) basis set. Total potential energy distribution analysis has been done for the detailed analysis of internal coordinates to each vibrational mode. The atom in molecule theory was applied via electron localization functions to examine ellipticity, binding energy, and isosurface projections. Natural bond analysis was conducted to investigate interference energy, bond hybridization, and interactions between donor and acceptor sites. Reactive sites were identified through Fukui functions and molecular electrostatic potential analysis. Thermodynamic properties, including free energy, enthalpy, entropy, internal energy, and heat capacities at various temperatures, were computed using the Atomistica online calculator. The electrophilicity index, derived from FMO analysis, suggested the compound’s potential bioactivity. Molecular docking studies with various proteins revealed the lowest binding energy of −4.9 kcal/mol. α-Aminobutyric acid and its derivatives exhibit similar Absorption, distribution, metabolism, and excretion (ADME) properties, indicating their potential utility in drug development. Minimal conformational changes in the peptide backbone after equilibrium have been explained by using molecular dynamics simulations, and molecular mechanics Poisson–Boltzmann surface area calculation showed an average free binding energy of −23.48 ± 1.72 kcal/mol.

Ultrasonic-Assisted alkali and polyvinyl alcohol treatment for enhancing the mechanical of sisal fiber and interfacial properties with starch

ABSTRACT Sisal fibers treated with alkali and polyvinyl alcohol (PVA) through ultrasonic impregnation yield various modified fibers with enhanced properties. In this study, the influence of PVA adhesion on the tensile strength, water absorption and thermal stability of individual fiber and the change of interfacial shear strength with starch were investigated. The fiber was characterized by infrared spectroscopy and electron microscope. Results reveal that PVA not only coats the surface but also penetrates the fibers, significantly improving tensile strength. Weibull distribution analysis showed that the tensile strength of ASF increased by 42.99% and the interfacial shear strength increased by 140.5%. The tensile strength of the PSF-1.0, analyzed using Weibull distribution, increased by 50.1%, and the interfacial shear strength improved by 112.9%. The study confirms that alkali and PVA treatment is a cost-effective, biodegradable method to enhance the tensile and interfacial binding properties of natural fibers, making them suitable for reinforced starch-based composites.

Finite Element Analysis of Stress Distribution in Cancellous Bone During Dental Implant Pilot Drilling

Background/Objectives: This study investigates stress distribution in cancellous bone during pilot drilling for dental implants using the Cowper–Symonds model. Understanding the biomechanical effects of drilling parameters on bone health is essential for optimizing implant stability and longevity. Methods: A finite element analysis (FEA) approach was employed to simulate the pilot drilling process in cancellous bone. A three-dimensional jawbone model was developed from CT scan data, processed using 3D Slicer, and refined with CAD tools. The drilling simulation incorporated a rigid pilot drill and flexible cancellous bone, utilizing explicit dynamic methods. Stress distribution was evaluated for drilling depths ranging from 6 mm to 16 mm, with mesh density and strain rate effects considered to ensure accuracy. Results: The results showed an increase in stress levels with drilling depth, with maximum stress recorded at 16 mm. Initial contact stress was 17.3 MPa, rising to 228.9 MPa at deeper penetration due to increased interaction between the drill and bone. Stress distribution patterns emphasized the critical role of drilling depth and design parameters in mitigating bone damage. Conclusions: This study highlights the importance of optimized drilling protocols and pilot drill design to reduce stress and preserve bone integrity. The findings provide valuable insights into improving implant procedures and demonstrate the utility of FEA as a robust tool for evaluating biomechanical impacts during implant placement. Future research should incorporate cortical bone and thermal effects for a comprehensive analysis.

The Spatial Distribution of Globular Cluster Systems in Early-type Galaxies: Estimation Procedure and Catalog of Properties for Globular Cluster Systems Observed with Deep Imaging Surveys

Abstract We present an analysis of the spatial distribution of globular cluster (GC) systems of 118 nearby early-type galaxies in the Next Generation Virgo Cluster Survey and Mass Assembly of early-Type GaLAxies with their fine Structures survey programs, which both used MegaCam on the Canada–France–Hawaii Telescope. We describe the procedure used to select GC candidates and fit the spatial distributions of GCs to a two-dimensional Sérsic function, which provides effective radii (half number radii) and Sérsic indices, and estimate background contamination by adding a constant term to the Sérsic function. In cases where a neighboring galaxy affects the estimation of the GC spatial distribution in the target galaxy, we fit two two-dimensional Sérsic functions, simultaneously. We also investigate the color distributions of GCs in our sample by using Gaussian mixture modeling. For GC systems with bimodal color distributions, we divide the GCs into blue and red subgroups and fit their respective spatial distributions with Sérsic functions. Finally, we measure the total number of GCs based on our fitted Sérsic function, and calculate the GC specific frequency.

Trench MOS Schottky Diodes: A Physics-Based Analytical Model Approach to Charge Sharing

Trench MOS Barrier Schottky (TMBS) rectifiers offer superior static and dynamic electrical characteristics when compared with planar Schottky rectifiers for a given active die size. The unique structure of TMBS devices allows for efficient manipulation of the electric field, enabling higher doping concentrations in the drift region and thus achieving a lower forward voltage drop (VF) and reduced leakage current (IR) while maintaining high breakdown voltage (BV). While the use of trenches to push electric fields away from the mesa surface is a widely employed concept for vertical power devices, a significant gap exists in the analytical modeling of this effect, with most prior studies relying heavily on computationally intensive numerical simulations. This paper introduces a new physics-based analytical model to elucidate the behavior of electric field and potential in the mesa region of a TMBS rectifier in reverse bias. Our model leverages the concept of shared charge between the Schottky and MOS junctions, capturing how electric field distribution is altered in response to trench geometry and bias conditions. This shared charge approach not only simplifies the analysis of electric field distribution but also reveals key design parameters, such as trench depth, oxide thickness, and doping concentration, that influence device performance. This model employs the concept of shared charge between the vertical Schottky and MOS junction. Additionally, it provides a detailed view of the electric field suppression mechanism in the TMBS device, highlighting the significant effects of the inversion charge on the MOS interface. By comparing our analytical results with TCAD simulations, we demonstrate strong agreement, underscoring the model’s accuracy and its potential to serve as a more accessible alternative to resource-intensive simulations. This work contributes to a valuable tool for TMBS device design, offering insights into electric field management that support high-efficiency, high-voltage applications, including power supplies, automotive electronics, and renewable energy systems.

Pathogenic potential of ornithogenic <i>Escherichia coli</i> strains detected in the Earth's polar regions

Introduction. Pathogenic strains of Escherichia coli are an important object of surveillance within the One Health concept in the wild, agriculture and human society. Migratory bird colonies and high latitude avian colonies may be points of active intraspecies and interspecies contact between different animal species, accompanied by the spread of pathogens. At the same time, the phylogeography of E. coli in relation to the presence of natural foci of colibacillosis in polar regions remains virtually unstudied. The aim of this study was to assess the pathogenic potential of E. coli strains from the polar regions of the Earth, based on the analysis of the genomes of these bacteria from typical ornithogenic ecosystems of the Arctic and Antarctic. Materials and methods. The study used collections of E. coli isolated from ornithogenic biological material during expeditions to high latitude areas of the Arctic (archipelagos of Novaya Zemlya, Franz Josef Land, Svalbard) and Antarctic (Haswell Archipelago). 16 cultures associated with avian E. coli (12 polar and 4 temperate strains) were selected for genome-wide sequencing using BGI technology. The annotation of the genomes focused on the identification of genes for pathogenicity factors and antimicrobial resistance, as well as the identification of strains belonging to individual genetic lineages using the cgMLST method. Results. The annotation of the genomes allowed their assignment to different sequence types in the multilocus sequencing typing and genome-wide sequencing typing schemes. The analysis of the geographical distribution of the sequence types of polar E. coli strains determined by the cgMLST method showed their global representation in geographically distant regions of the planet. For example, cgST 133718 was observed in Antarctica (strain 17_1myr) and in the UK, and sequence 11903, to which strain 32-1 from the northernmost point of Novaya Zemlya belonged, was previously identified in the USA. All strains studied were characterized by the presence of extensive virulence. Among the pathogenicity factors identified were haemolysins A, E, F, siderophores, including the yersiniabactin gene cluster, a number of adhesion, colonization and invasion factors, as well as the thermostable enterotoxin EAST-1 and genes that characterize enteroaggregative strains of E. coli (the virulence regulator gene eilA and enteroaggregative protein (air)). One of the Arctic strains (33-1) had determinants of antibiotic resistance, in particular the extended-spectrum beta-lactamase gene TEM-1b and the Tn1721 transposon, including tetracycline resistance genes (tetA-TetR), were detected in its genome. Conclusion. The results of the study indicate the circulation of E. coli strains with strong pathogenic potential in high-latitude Arctic and Antarctic ornithogenic ecosystems. The analysis of genomic data indicates the presence of geographically widespread genetic lineages in these regions, which justifies the importance of monitoring epidemic clones of E. coli, along with monitoring for other pathogens, in bird colonies in high-latitude areas.

Analysis of Electric Field Distribution on Primary Windings of High-Voltage High-Frequency Transformers with Variables Characteristics

This research aims to present a study of the effects of the Tesla transformer in order to find the proper dimensions. We created a design of the Tesla transformer to reduce the high-voltage electric field-stress problem that happens between primary winding and secondary winding. Because the Tesla transformer is used to induce voltage between these two windings through the air, problems with insulation occur. The winding that has space is dielectric; while there is high voltage in a transformer, it causes flashover voltage between the high-voltage winding and low-voltage winding, which damages the transformer and other devices. Research process: Research was conducted to study the laydown model (positioning) of the two windings in the transformer. By considering this, we induced a proper Tesla transformer that was reproduced by using the FEMLAB program. Moreover, we compared the Tesla transformer reproduction, which created a voltage of 120 kV and a frequency of 120 kHz. The result from the comparison is a proper laydown position of the primary winding and voltage, which has been designed without the flashover. The whorl coil has to be wound at a 60-degree angle relative to the floor and can induce more voltage than other models. The voltage and corresponding electric field stress were measured for the primary winding at various angles relative to the floor (0-, 30-, 45-, 60-, and 90-degree angles) to determine the configuration. The results from the reproduction using the FEMLAB program and testing demonstrated that no flashover occurred between the high-voltage winding to the low-voltage winding when the primary winding was positioned at a 60-degree angle.

Quantitative susceptibility mapping of iron deposition in sporadic cerebral cavernous malformation-related epilepsy.

To evaluate iron deposition patterns in patients with cerebral cavernous malformation-related epilepsy (CRE) using quantitative susceptibility mapping (QSM) for detailed analysis of iron distribution associated with a history of epilepsy and severity. This study is part of the Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy (CRESS) cohort, a prospective multicenter study. QSM was used to quantify iron deposition in patients with sporadic cerebral cavernous malformation (CCMs). Lesions were segmented into intralesional, perilesional, and extralesional areas, with mean susceptibility values calculated for each subregion and analyzed in relation to epilepsy severity and duration. Among the 46 patients studied, those with a history of epilepsy had significantly higher iron deposition values in the perilesional (p =.012) and extralesional areas (p =.01), as well as a greater extent of iron deposition (p <.001) compared to those without epilepsy. The extent of iron deposition effectively distinguished patients with and without epilepsy, with an area under the curve (AUC) of 0.901 (95% confidence interval [CI]: 0.816-0.985). Among patients with epilepsy, iron deposition in the extralesional area was positively correlated with the severity of epilepsy (r2 = 0.181, p =.043), and the extent of iron deposition was positively correlated with the duration of epilepsy (r2 =.214, p =.026). This study highlights QSM as a non-invasive tool for assessing iron deposition in CRE, identifying distinct subregional iron deposition patterns linked to epilepsy status and severity.

Dynamics Analysis of Spatial Distribution and Landscape Pattern of Wetlands in the Weihe River Basin from 1980 to 2020

The wetland ecosystem is one of the most important carbon sinks on Earth, the most biodiverse ecological landscape in nature, and one of the most important living environments for human beings. The Weihe River wetland is located in the Guanzhong Plain urban agglomeration, with extreme climate and urban expansion having a great impact on its dynamic changes. Revealing the characteristics of and trends in wetland dynamics in the Weihe River Basin is the key to protecting and maintaining the healthy development of the Weihe River wetlands. This paper analyzed the changing characteristics of land use types and landscape patterns in the wetlands of the Weihe River Basin using wetland land use data from six periods in the Weihe River wetland from 1980 to 2020 and explored the spatial and temporal distribution characteristics and dynamic changes in wetlands in the Weihe River Basin. The results showed the following: (1) Wetlands in the Weihe River Basin, dominated by rivers, saw area fluctuations with an initial decline followed by an increase. Land use changes followed a slow–fast–slow trend. (2) From 1980 to 2020, frequent conversions among wetland types were observed. The primary transformation was the conversion of marshes into lakes (18.05 km2) and reservoirs/ponds (17.98 km2). Approximately 0.06 km2 of lakes were transformed into canals/channels. (3) River patches have the largest area, while canals/channels have the smallest. The patch density (PD) and landscape shape index (LSI) of wetlands fluctuate significantly, and the reduction in area leads to a 3.46% decrease in aggregation index (AI). Shannon’s diversity index (SHDI) has decreased by 5.41%. (4) The centroid of marshes experiences significant changes, while river changes are complex. The centroid changes in reservoirs/ponds are located along the southeast–northwest line. Canals/watercourses remain stable. Lakes exhibit the longest migration. This study provides robust scientific support for wetland ecological protection, policy formulation, and social sustainable development by conducting an in-depth analysis of the dynamic change characteristics of wetlands in the Weihe River Basin.

Intraspecific genetic variation in the lymphatic filariasis vector Mansonia dives (Diptera: Culicidae) in Thailand: Hidden species or genetically divergent populations?

Mansonia dives is recognized as a vector for brugian filariasis in Thailand. A recent study analyzing the cytochrome c oxidase subunit I (COI) gene revealed two distinct clades within the Ma. dives population in Thailand. This study aimed to examine the genetic diversity and structure of Ma. dives using the COI gene and the internal transcribed spacer 2 (ITS2) region to determine the presence of distinct species or genetically divergent populations. We analyzed 60 COI and 60 ITS2 sequences from Ma. dives populations in Narathiwat, Ranong, Tak, and Trat. The results showed a nucleotide diversity of 0.019 and a haplotype diversity of 0.979 for the COI gene, while the ITS2 region displayed a nucleotide diversity of 0.005 and a haplotype diversity of 0.545. Phylogenetic and haplotype network analyses of the COI gene identified two genetic lineages: one confined to Trat and another encompassing the other sites. However, species delimitation methods suggested that these genetic differences were insufficient to classify the lineages as distinct species. In contrast, the ITS2 analysis indicated a uniform genetic pattern across all populations. We conducted neutrality tests and mismatch distribution to examine the demographic history. For the COI gene, Tajima's D was slightly positive and non-significant (0.014), while Fu's Fs was negative (-9.750), indicating a potential expansion phase. Conversely, for the ITS2 region, Tajima's D and Fu's Fs were positive and non-significant, suggesting that the population might be in equilibrium or undergoing contraction. Moreover, the mismatch distribution analysis for the ITS2 region was inconclusive. The apparent discrepancies between these markers indicate the presence of genetically divergent populations, rather than distinct species.

Percolation analysis of spatiotemporal distribution of population in Seoul and Helsinki

Percolation analysis of spatiotemporal distribution of population in Seoul and Helsinki

Phytochemicals Withanolide N and Dryobalanolide as Potential Bioactive Leads for Developing Anticancer Drugs Targeting Tyrosine-Protein Kinase Mer.

There is a growing interest in harnessing natural compounds and bioactive phytochemicals to accelerate drug discovery and development, including in the treatment of human cancers. Receptor tyrosine kinases (RTKs) are critical regulators of many fundamental cellular processes and have been implicated in cancer pathogenesis as well as targets for anticancer drug development. The members of TAM, Tyro3, Axl, and MERTK subfamily RTKs, especially Mer, affect immune homeostasis in the tumor microenvironment. Hence, tyrosine-protein kinase Mer has emerged as one of the key factors in cancer susceptibility and metastasis and, by extension, as a potential target of relevance for cancer drug resistance. Here, we report, using an integrated virtual screening and simulation of phytochemicals from the IMPPAT 2.0 library, phytochemicals withanolide N and dryobalanolide as potential bioactive leads for developing anticancer drugs targeting tyrosine-protein kinase Mer. The study employed an integrated design, including physicochemical property analyses, binding affinity calculations, pan-assay interference compounds filtering, absorption, distribution, metabolism, excretion, and toxicity, and PASS analyses, in silico molecular dynamics simulations, followed by principal component analysis and free energy landscape. We call for further evaluation, validation, and translational medical research on these two phytochemicals in vitro and invivo, with an eye to their putative therapeutic efficacy and safety in the field of oncology and anticancer drug discovery and development.