This systematic review and preliminary meta-analysis examined the effectiveness of translated versions of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and the MMPI-2 Restructured Form (MMPI-2-RF) in detecting response distortion (i.e., symptom exaggeration and minimization), a central concern in forensic assessment. We hypothesized that translated versions of the MMPI-2 and MMPI-2-RF would generate significantly weaker effect sizes in detecting response distortion than those observed with English-language studies. We identified 26 studies, representing seven language translations of the MMPI-2 (k = 20) and two of the MMPI-2-RF (k = 6). We calculated effect sizes (Cohen's ds) based on the mean score difference between honest and nongenuine responders for each study on each symptom exaggeration (e.g., F/F-r, Fp/Fp-r) and minimization (e.g., L/L-r, K/K-r) scale examined, along with mean effect size estimates (Hedges' g) for the Spanish and Italian translations (no other translation had more than two published studies). Spanish-language studies generally produced large (d ≥ 1.25) to very large (d ≥ 1.75) effect sizes when detecting both symptom exaggeration and minimization. Italian-language studies generally produced small to moderate effect sizes when detecting symptom exaggeration and predominately moderate (d ≤ 1.25) effect sizes when detecting minimization. Significant variability within and across scales was observed in both Spanish-language and Italian-language studies. Most studies utilizing a translated version of the MMPI-2 other than Spanish or Italian produced very large (d ≥ 1.75) effect sizes when detecting symptom exaggeration and weaker (d ≤ 1.00) effect sizes when detecting minimization. This systematic review and preliminary meta-analysis demonstrated effect sizes that overlapped with those observed in English-language studies. Although clearly preliminary, given the limited published research to date, these data suggest that the MMPI instruments retain some utility in detecting response distortion when translated. (PsycInfo Database Record (c) 2022 APA, all rights reserved).