This article presents a review of the combined analysis of digital terrain models (DTMs) and remotely sensed data in landscape investigations. The utilization of remotely sensed data with DTMs has become an important trend in geomatics in the past two decades. Models of more than ten quantitative topographic variables are employed as ancillary data in the treatment of images. The article reviews the methods for DTM derivation and the basic problems of DTM operation that are important for handling DTMs with imagery, namely: 1) the choice of a DTM network type; 2) DTM resolution; 3) DTM accuracy; and 4) the precise superimposition of DTMs and images. The processing of remotely sensed data and DTMs in combination is used in the following procedures: 1) the image correction of the topographic effect; 2) the correction of geometric image distortion; 3) image classification; 4) statistical and comparative analyses of landscape data; and 5) three-dimensional landscape modelling. These procedures are applied to solve a wide range of problems in geobotany, geochemistry, soil science, geology, glaciology and other sciences. The joint use of imagery and DTMs can increase the total amount of information extracted from both types of data. The trend has been towards the incorporation of the combined analysis of remotely sensed data and DTMs into mixed environmental models. The following potential applications of the treatment of imagery in association with DTMs are identified: 1) the prediction of the migration and accumulation zones of water, mineral and organic substances moved by gravity along the land surface and in the soil; 2) the investigation of the relationships between topographically expressed geological structures and landscape properties; 3) the improvement of geological engineering in industrial planning (e.g., the construction of nuclear power stations, oil and gas pipelines and canals); and 4) the monitoring of existing industries. Digital models of plan, profile, mean and total accumulation curvatures, and nonlocal and combined topographic attributes should be included in data processing both to solve the problems indicated and to improve the outcome of some regular tasks (for example, the prediction of soil moisture distribution and fault recognition).