AbstractProximal gastric vagotomy (PGV) was performed in 40 patients who had suffered from dyspepsia for several years, but who did not have any demonstrable ulcer. Great care was taken to obtain a thorough history of the disease. Patients with symptoms not likely to be caused by gastric hypersecretion were not treated surgically. There was a distinctive reduction of both basal and pentagastrin‐stimulated acid secretion after the operation. The decrease in acid output was accompanied by a marked relief of symptoms. Most patients noted the improvement within 3 months after surgery. Thirty patients were interviewed after 5 years. Of these, 23 were either completely cured of dyspepsia or were at least much better than before the operation. Only 1 person reported no relief 5 years after PGV. It is concluded that surgical treatment may be of value in patients with chronic dyspepsia even in the absence of a peptic ulcer.