This paper presents the design of wireless sensor network (WSN) based on low-power wide area network technology for high-tech agriculture. This WSN allows the farmer to collect data such as air temperature, air humidity, soil moisture. The WSN system consists of components: 02 wireless sensor nodes, 01 gateway, 01 cloud server and smartphone app. This WSN tested for data transmission in two zones: zone 1 (dense urban environments) at a distance of 500m and zone 2 (urban environments - less obstacles) at a distance of 1,500m and 1,700m. The data collected at different times of the day and updated every 15 minutes. The results show that the wireless sensor network system operates stably, data constantly updated to LoRa Server and there was not data packet loss. The power consumption of sensor node and gateway determined in three operating modes: transmitting, receiving, turn-off. This shows the advantages of LoRa technology in the development of wireless sensor network which is the distance of data transmission distance and low power consumption. Besides this WSN also tested in the net house of aquaponics of the Research Center for High-tech Application in Agriculture (RCHAA), University of Science, Vietnam National University-HCM. The results show that the WSN system is working reliably and promising which brings significantly benefits to smart agriculture as aquaponics, clean vegetable farms, aquaculture farms…