The study examines pedagogy and technical implication of blended learning in Obafemi Awolowo University Centre for Distance Learning. The research design method used for this study was survey research methods. The population of the study comprises of Two hundred and fifty (250) registered nursing students for 2021/2022 academic session at Obafemi Awolowo University Centre for Distance Learning programmes. The sample size of One hundred and fifty-two (152) respondents was selected through the Krejcie and Morgan sampling techniques to select the sample size from the population. The returned rate of the instrument used to elicit the data from the respondents was 142(93.42%). The instrument used to collect data was questionnaire. This questionnaire was designed on a scale of 4 points Likert. The validity of the instrument was done and the reliability of the instrument was tested through the use of Cronbach Alpha reliability tools to determine the internal consistency of the instrument. The instrument revealed a coefficient of 0.702 which is acceptable. The method of data analysis used was analysis of variance (ANOVA) statistics to test the research hypotheses. The statistical package for social sciences (SPSS) was used to analyse the data. The findings revealed learners technology skill (N = 142; F = 3.543; P = 0.016 @ 0.05).Teaching flexibility (N = 142; F = 0.908; P = 0.439 @ 0.05). Learner self-efficacy (N = 142; F = 0.277; P = 0.842 @ 0.05). Personal commitment (N = 142; F = 2.220; P = 0.089 @ 0.05) are positively significant with the technical implication of blended learning. Hypothesis one was rejected while other hypotheses were sustained. The implication was that learners portrayed certain IT skills which ease their understanding of blended learning. The study therefore recommended that the tertiary institution stakeholders should fund blended learning for both teachers and students. Also, build a supportive technological environment and creating a technical hub for students will lower education costs and promote academic advancement. Keywords: Pedagogy, Technical Implication, Blended Learning and Distance Learning.