Distal Wall Research Articles

The state of lipid exchange, hemostasis, inflammatory reaction and potentials for their correction in indirect revascularization in patients with critical ischemia of lower extremities (a correlation statistical analysis)

Aim:to study the state of lipid metabolism, hemostasis, inflammatory reaction and the potential for their correction after indirect revascularization in patients with distal steno-occlusion of arteries and critical ischemia of lower extremities (critical ILE).Material and methods.Changes in hemostasis and dynamics of its parameters during the complex surgical treatment in 131 patients with critical ILE and distal arterial stenoocclusion were analyzed. To achieve the targeted goals, patients were divided into the following groups: 34 patients had traditional care (control group); 32 patients had intravenous laser blood irradiation in combination with standard therapy (Group I); 32 patients had cytokine therapy with roncoleukin in combination with standard therapy (Group II); 33 patients had intravenous laser blood irradiation combined with cytokine therapy and standard therapy (Group III). Parameters of lipid metabolism were studied in dynamics (total cholesterol, very low density lipoproteins, high density lipoproteins, triglycerides); products of lipid peroxidation (malondialdehydes, conjugates, superoxide dismutase); inflammatory mediators (C-reactive protein, sialic acids, seromucoids, fibrinogen A, circulating immune complexes); hemostatic parameters (fibrinogen, fibrinolytic activity, fibrin degradation products, antithrombin III activity). Hemostatic indices were compared with identical parameters of 48 apparently healthy individuals (reference group).Results.On admission, patients with critical ILE and distal wall occlusion had sharp changes in their lipid metabolism, inflammatory reaction, and hemostasis. Conclusion. The inclusion of intravenous laser blood irradiation and cytokine therapy separately and in combination in a set of therapeutic measures led to the leveling of the studied homeostasis indicators. The best results were obtained in the group where patients had combined perioperative intravenous laser blood irradiation with cytokine therapy in indirect revascularization.

A Comparative Study of the Accuracy of Dental CAD Programs in Designing a Fixed Partial Denture.

Error testing at each stage of prosthetic manufacturing remains relatively underdeveloped for computer-aided design/computer-aided manufacturing methods, and no experimental studies have validated the computer-aided design programs. This study aimed to test the accuracy and trueness of the computer-aided design of a three-unit fixed prosthesis. Three computer-aided design programs (Exocad, Dental System™, and inLab 16) were tested on the designs of a three-unit fixed partial denture, and a three-dimensional analysis program was used to calculate the internal clearance error for the computer-aided design prostheses. The Kruskal-Wallis and Dunn's post hoc tests were used to reveal significant differences in trueness between the three computer-aided design programs (α < 0.05). Dental System™ showed the lowest mean error values for #24 and #26 at the mesial margin (both 0 µm), mesial wall (0.10, 0.12 µm, respectively), occlusal surface (-0.05, 0.10 µm), distal wall (0.23, -0.02 µm), and distal margin (both 0 µm). In sum, except for the mesial margin and distal margin site of tooth #26, the mean error value of Dental System™ was statistically the lowest, followed by those of Exocad and inLab 16 (p < 0.003). The accuracy of computer-aided design differed according to the type of computer-aided design program. Dental System™ achieved the best trueness at the margins, axial walls, and occlusal surface, followed by Exocad and inLab 16.

The effect of rotary instrumentation on dentin thickness in the danger zone of the MB2 canal of maxillary first molars.

The aim of this study was to measure the initial and remaining dentin thickness in the danger zone of the second mesiobuccal (MB2) canal of maxillary first molars after rotary instrumentation using cone beam computed tomography (CBCT) imaging. After determining initial dentin thickness, each sample was subjected to a standardized protocol of rotary instrumentation files: ProTaper Gold Sx Orifice Opener (maximum depth of 7 mm); Vortex Blue 15.04, 20.04, 25.04, ProTaper Gold S1, S2, F1, F2, and finally Vortex Blue 30.06. Subsequent CBCT measurements were made to compare changes in remaining dentin thickness in comparison to initial presentation. Preoperative dentin thickness in the danger zone had a mean of 0.82 ± 0.17mm. Significant levels of dentin removal in the danger zone were noted after all instrumentation groups when compared to the pre-instrumentation mean (Sx P < 0.001, 25.04 P < 0.0006, F2 P < 0.0001, 30.06 P < 0.0001). It was concluded that a thin area of dentin exists along the distal wall of the MB2 (danger zone) from the furcation to 4 mm apically.

VAGINAL PLATELET-RICH PLASMA ADMINISTRATION TO IMPROVE FEMALE SEXUAL SATISFACTION

Objective:To investigate the effect of platelet-rich plasma (PRP) injection to the lower one-third of the anterior vaginal wall on sexual function, orgasm, in women with sexual dysfunction by scoring with FSFI. Materials and Methods:Three sessions of PRP (platelet rich human autologous plasma) were administered to the anterior vaginal wall of fiftyfemale patients with sexual dysfunctiondiagnosed by FSFI scoring card obtained in JAM clinic in Benha city Egypt and orgasmic disorder. Female Sexual Function Index (FSFI) total score ≤26 orgasmic subdomain score ≤3.75 were considered having sexual dysfunction and recruited in the study. Results:Following the application of the PRP, the total FSFI score was observed as 27.7±4.5 and the total score was 26 and above in patients having sexual dysfunction (p&lt;0.001). Orgasm subdomain scores were found as 2.2±1.2 before the PRP treatment and 4.4±1.06 at the third dose after (p&lt;0.001). Conclusion:PRP administration to the distal anterior vaginal wall improved female sexuality with high satisfaction by using multiple sessions (three month).

Changes of pelvic organ prolapse and pelvic floor dysfunction throughout pregnancy in singleton primigravidas: A prospective cohort study

ObjectiveTo document the deterioration in pelvic organ support occurring throughout all trimesters during the first pregnancy of women with no known risk factors. Secondarily to make a comprehensive review in order to verify the current findings and methodologies of similar studies in the literature. Study DesignIn this prospective study, forty-one primigravid women with a singleton pregnancy were recruited during their first trimester. During follow-up pelvic organ support changes were documented by using Pelvic Organ Prolapse Quantification (POP-Q) system. Additionally, pelvic floor muscle strength examination, by modified Oxford scoring (MOS), and symptom assessment by Pelvic Floor Distress Inventory-Short Form (PFDI-20) were performed at three time points: first (T1), second (T2), and third trimester (T3) (n = 33). The Wilcoxon test was performed to test the significance of pairwise differences. Spearman correlation coefficient was estimated to determine the linear association of the findings. ResultsBoth distal and proximal anterior and posterior vaginal walls (Points Aa, Ba, Ap and Bp) with cervix (C) descended towards the hymen, throughout first pregnancy with a significant caudal shift on progressing from T2 to T3 (p ≤ 0.017). Posterior fornix (Point D) made a non-significant cranial shift (p = 0.527). The genital hiatus, perineal body and total vaginal length increased significantly (p ≤ 0.001). No significant difference in MOS was observed throughout pregnancy. The scores of PFDI-20 with all its domains worsened significantly during pregnancy, especially in T3 (p ≤ 0.011). Moderate correlations were observed between posterior vaginal descent and anorectal symptoms (rho 0.427, p < 0.05), and between the changes in genital hiatus and prolapse symptoms (rho 0.406, p < 0.05). ConclusionA significant descent both in all compartments of vaginal wall and perineum with an increase in total vaginal length, was observed together with an associated pelvic floor dysfunction throughout the first pregnancy of women.

Influence of preexisting salt diapirs during thrust wedge evolution and secondary welding: Insights from analog modeling

Salt lithologies are mechanically weaker than other sedimentary rocks. Salt horizons usually act as décollements and precursor salt bodies preferentially deform early during contraction, concentrate deformation, and impact the structural style and kinematics during mountain building. Focusing on shortened isolated-diapir provinces, our analog modeling program investigates the influence of two salt walls on folding and thrusting.High resolution topographic scans and particle image analysis show that the presence of precursor diapirs impacts the layer parallel shortening patterns and presumably the stress field at the onset of contraction. Shortening concentrates on diapirs, leading to roof arching, crestal extension and salt extrusion. This sequence of events occurs earlier on thinner salt-sediment sequences including diapirs having well-developed pedestals, particularly when proximal to the deformation front. Folds and thrusts nucleate at salt walls if they feature a well-developed pedestal. Further shortening results in secondary welding as evidenced by the collapse of uplifted roof domes, cessation of indentation and reverse faulting nucleated at the secondary welds. Meanwhile, and depending upon the processes occurring on the diapir closer to the backstop, the deformation of the distal salt wall is discontinuous.Our modeling results are compared with experimental works and natural examples from the Fars (Zagros Mountains).

Can olive oil prevent distal colon mucosal atrophy caused by disuse in rats with colostomy? An experimental animal study.

This study aims to investigate the effects of pure olive oil on mucosal atrophy of the distal colon in rats. &lt;br/&gt;&lt;br/&gt;Material and methods: The study included 28 male albino Wistar rats weighing 300-350 g. A total of 28 animals were randomly allocated to four groups: group 1: control group (n = 6); group 2: ostomy group (n = 6); group 3: ostomy + saline group (n = 8); group 4: ostomy + olive oil group (n = 8). By definition, group 1 did not undergo any procedure. The same surgical procedure was performed for groups 2, 3, and 4 as described below. In all animals from these groups, a two-centimeter-long mid-line incision was made and the colon was divided into 5 cm sections, measured from the distal colon to the caecum. Proximal and distal stomas were created 2 cm apart in the midline with the use of single-layer interrupted sutures. All rats were kept under close daily observation until they were terminated postoperatively after the 1st month. Animals from group 2 did not undergo any additional procedures, while those fromgroups 3 and 4 were given 2 mL of saline and olive oil twice a day, respectively. At the end of the 1st month, the rats were re-operated through the same approach. Biopsies were taken from the proximal and distal stomas of all rats in the same manner for further histopathological analysis. &lt;br/&gt;&lt;br/&gt;Results: Group 1 showed no significant differences in terms of mucosal thickness, muscular thickness, wall thickness or colonic lumen diameter between the proximal and distal segments of the colon. Although there were significant differences between the proximal and distal colostomies for each parameter in groups 2, 3, and 4, the mucosal thickness, muscular thickness, wall thickness, and colonic lumen diameter differences for proximal and distal ostomies were very small in group 4 when compared to groups 2 and 3. &lt;br/&gt;&lt;br/&gt;Conclusion: The administration of pure olive oil through the distal colon before colostomy closure may reduce the difference in diameter between the proximal and distal intestinal segments. As a result, a more straightforward surgical procedure may be achieved.

Etching of the seed cuticle by cold plasma shortens imbibitional leakage in Linum usitatissimum L.

Pre-sowing treatment of seeds with cold plasma, a reactive mixture of charged particles, is an emerging, environmentally friendly method, shown to improve water absorption, germination and seedling growth in many crop species. We studied how plasma affects different structural layers in flax seed coats, and focused on the effects on some of the earliest germination events, directly related to imbibition: solute leakage and mucilage extrusion. We characterized the ultrastructure of flax seed coats using scanning electron microscopy (SEM) and observed mucilage extrusion in situ, using environmental SEM. Time-courses of water uptake and solute leakage during germination were recorded, respectively, by weighing the seeds and semi-quantitative metabolite profiling of the exudates using GC–MS, LC–MS and LC–UV. Plasma treatment perforated the cuticle of flax seeds but did not visibly etch the underlying mucilage secretory cell (MSC) walls. Plasma treated seeds took up more water than untreated seeds during imbibition. Mucilage expansion of untreated seeds detached the distal MSC walls from the radial walls and extrusion occurred, relatively slowly, via sparse cracks in the distal cell wall layer. In plasma treated seeds, mucilage extrusion occurred fast, via rupture of distal cell walls of almost every single MSC, and the junctions between distal and radial MSC walls remained intact. Initially, imbibitional solute leakage was higher in plasma treated seeds but the leakage had quasi stopped after one hour of imbibition. In untreated seeds, the leakage continued amply more than two hours after the start of imbibition. Fragments of the lignan macromolecule, stored in parenchymatous cells under the MCS, were released more abundantly in the spermosphere of plasma treated than untreated flax seeds. It is concluded that plasma treatment etches the cuticle of flax seeds and weakens the underlying MSC cell walls, and that such treatment leads to significantly faster recovery of membranes during imbibition, reducing leakage time in germinating seeds.

Urethral support in female urinary continence part 1: dynamic measurements of urethral shape and motion.

Urethral closure mechanism dysfunction in female stress urinary incontinence (SUI) is poorly understood. We aimed to quantify these mechanisms through changes in urethral shape and position during squeeze (voluntary closure) and Valsalva (passive closure) via endovaginal ultrasound in women with varying SUI severity. In this prospective cohort study, 76 women who presented to our tertiary center for urodynamic testing as preoperative assessment were recruited. Urodynamics were performed according to International Continence Society criteria. Urethral pressures were obtained during serial Valsalva maneuvers. Urethral lengths, thicknesses, and angles were measured in the midsagittal plane via dynamic anterior compartment ultrasound. Statistical shape modeling was carried out by a principal component analysis on aligned urethra shapes. Age, parity, and BMI did not vary by SUI group. Ultrasound detected a larger retropubic angle, urethral knee-pubic bone angle (a novel measure developed for this study), and infrapubic urethral length measurements at Valsalva in women with severe SUI (p = 0.016, 0.015, and 0.010). Shape analysis defined increased "c" shape concavity and distal wall pinching during squeeze and increased "s" shape concavity and distal wall thickening during Valsalva (p < 0.001). It also described significant urethral shape differences across SUI severity groups (p < 0.001). Dynamic endovaginal ultrasound can visualize and allow for quantification of voluntary and passive urethral closure and variations with SUI severity. In women with severe SUI, excessive bladder neck and distal urethra swinging during Valsalva longitudinally compressed the urethra, resulting in a proportionally thicker wall at the mid-urethra and urethral knee.

Synthesis of quinoxaline cavitand baskets

ABSTRACT The unique temperature, solvent and pH drivenvase to kite equilibrium in quinoxaline cavitands allows the reversible uptake and release of guests. However, the cavity breathing associated with this conformational switch reduces the strength of complexation. A limited number of solutions have been proposed for the cavity rigidification, using either H-bonding, metal coordination or covalent connections. Here we report the synthesis and structural characterisation of quinoxaline-based cavitand baskets, which present two distal quinoxaline walls linked together. Baskets A and B were obtained through a bridging reaction starting from an AC di-quinoxaline bridged cavitand using two different di-quinoxaline moieties. In both cases, two isomers were obtained: isomer C2, with the linking unit crossing the cavity mouth, and isomer Cs, having the linker sideways. The isomers were identified through 1H NMR analysis. In the case of basket A-Cs, the resolved molecular structure confirmed the Cs symmetry of the basket.

Institutional experience of in-stent stenosis after pipeline flow diverter implantation: A retrospective analysis of 6 isolated cases out of 118 patients.

Pipeline embolization devices (PLEDs) are flow diverting stents that have exhibited be safe and efficient in the treatment of complex aneurysms. Nevertheless, in-stent stenosis (ISS) has been reported as one of the cardinal complications associated with PLED. The association of wall malapposition and ISS in patient treated with PLED has not been reported.A retrospective study was conducted to identify patients with ISS after implantation of PLED as treatment for intracranial aneurysms from April 25, 2018 to April 24, 2019. Incidence of ISS and its associated causes such as sharp change of the PLED, distal wall malapposition, inconsistent compliance between parent artery as well as the PLED occlusion due to intimal hyperplasia and vessel tortuosity. Assessment of conservative treatment and retreatment outcomes of ISS were documented.In all, 6 ISS cases were identified by 2 independent neurointerventionalists out of 118 aneurysm patients treated with PLED. Thus, the incidence rate of ISS in patients treated with PLED was as low as 5% at our institution compared to other studies. The follow-up time for detection of ISS ranged from 6 to 12 months after implantation. Several combinations of reasons such as sharp change of the PLED, distal wall malapposition, inconsistent compliance between parent arteries as well as PLED occlusion due to intimal hyperplasia and vessel tortuosity accounted for the causes of ISS during our analysis. Conservative treatment with a combination of antiplatelet during follow-ups did not resolve the ISS in our study probably due to associated underlying factors above.

A Modified Levine Approach for Exposure of the Anterior Column, Anterior Wall, and Sacroiliac Joint: A Surgical Technique and a Case Series.

Surgical exposure of the anterior column, anterior wall, pelvic brim, and sacroiliac joint is accessible through the lateral window of the ilioinguinal approach. Residual attachment of the abdominal muscles and inguinal ligament to the anterior superior iliac spine (ASIS) is often a limiting factor to expanded distal and medial exposure, especially in patients with a large abdomen that hangs over the pelvis. An ASIS osteotomy has been described to improve exposure, particularly of the distal anterior wall and joint capsule, pubic ramus, and anterior quadrilateral plate. However, an ASIS osteotomy can be troublesome to reattach. In this study, we introduce a soft tissue release technique to mobilize the abdominal muscles and inguinal ligament to allow expanded surgical access to the distal anterior column/wall and sacroiliac joint and to create a working space for fracture reduction and fixation.

The polyclad fauna (Platyhelminthes, Rhabditophora) of the Sinop Peninsula (Black Sea, Turkey) with the description of a new species of Cryptocelis Lang, 1884

Between October 2013 and July 2014, 40 polyclad specimens were collected during the systematic sampling of mussel beds along the coast of the Sinop Peninsula (Western Black Sea). Six species were identified, including a new Cryptocelis species. Cryptocelis sinopae sp. nov. is characterized by possessing a prostatic vesicle lined with a ridged fold in its anterior end and the presence of two secretory glandular folds in the distal dorsal wall of male atrium. Additionally, new records of Echinoplana celerrima Haswell, 1907 and Leptoplana mediterranea (Bock, 1913) are reported for the Black Sea and Turkey; and Leptoplana tremellaris (Müller OF, 1774) and Prosthiostomum siphunculus Delle Chiaje, 1822 for the coast of the Black Sea of Turkey. A short description of the reproductive behaviour of Pleioplana okusi Bulnes, Kalkan and Karahan, 2009 and Cryptocelis sinopae sp. nov. will be also provided.

Influence of remaining tooth substance and post-endodontic restoration on fracture strength of endodontically treated maxillary incisors.

The aim is to evaluate the influence of remaining tooth substance and post-endodontic restoration on fracture strength of endodontically treated maxillary incisors. 150 maxillary central incisors were divided into three groups, Group 0, intact teeth; Group 1, removal of distal wall; Group 2, removal of mesial and distal walls, and further into two subgroups A0,A1,A2 and B0,B1,B2 according to post-endodontic restoration (post/no-post), then loaded to fracture. Interactions among variables and intergroup significance were tested with two-way ANOVA and Kruskal Wallis's tests (p≤0.05). Tukey's test was applied for multiple comparisons. Statistically significant differences were found between groups B1-A1, and B2-A2, but they were not found between B0-A0. Intragroup analysis showed statistically significant differences in both groups post/no-post with decreasing dental substance. Fiber post placement causes an increase in fracture strength and a reduction of irreparable fractures in endodontically treated maxillary central incisors that lost at least one wall.

Intestinal Adenocarcinoma with Cloacal Prolapse and Reduction in a Northern Leopard Frog (Lithobates pipiens)

Over a 3-month period, a 6-yr-old, wild-caught, northern leopard frog (Lithobates pipiens) presented for reoccurring cloacal prolapse, despite surgical correction. Two contrast radiographic series performed approximately 6 wk apart showed intestinal obstruction and gastrointestinal dysmotility, while exploratory coeliotomy revealed a minor intestinal intussusception. Approximately 6 months after the fourth and final prolapse had resolved, the animal died of natural causes. Necropsy examination exposed a large, ill-defined thickening of the distal intestinal wall, with proximal intestinal dilation. Histopathology revealed a mass composed of polygonal cells, with occasional intracytoplasmic mucin arranged in sheets, and poorly formed acini, consistent with an intestinal adenocarcinoma. A presumptive metastatic lesion was identified in the kidney (microscopically). Herpesvirus-specific consensus polymerase chain reaction (PCR) and nested PCR assays performed on the formalin-fixed, paraffin-embedded intestinal and kidney masses for ranid herpesvirus 1 were negative. Few reports of intestinal adenocarcinoma in amphibians exist in the literature. To the authors' knowledge, this represents the first report of spontaneous intestinal adenocarcinoma in a northern leopard frog.

Ultrastructure of epithallial cells and trichocyte initials in Amphiroa (Corallinales, Rhodophyta), and possible systematic value of trichocyte development in corallines

ABSTRACT To better understand the dynamics of the coralline algal thallus surface, scanning and transmission electron microscopy were used to examine the structure and development of epithallial cells and trichocyte initials in three species of Amphiroa. Epithallial cells possessed several distinctive organic wall layers. A densely fibrillar, moderately electron-dense layer completely surrounded each epithallial cell. Inward of this layer on the distal cell face, irregular deposits of wall material projected into the cell lumen. Outward on the distal cell surface, an electron-dense layer tapered from a central conical projection. This cone of distal wall material originated before the epithallial cell that ultimately bore it, having been deposited by an initial cell to sever its connection with a senescing epithallial cell in advance of epithallial cell replacement. This wall feature provided an indication of epithallial cell regeneration. Trichocyte initials were present beneath the layer of epithallial cells. The calcified sidewall of the epithallial cell overlaying the trichocyte chamber contained a channel that terminated in a pore through which the shaft of a trichocyte could pass. Lateral to the trichocyte initial, uncalcified walls still bearing pit plugs once shared by the initial cell and multiple generations of lost and regenerated trichocytes were compressed against the side of the trichocyte chamber. A single section of one trichocyte chamber showed 17 remnant pit plugs, indicating a high frequency of trichocyte turnover. Comparisons drawn from the published literature suggest that trichocyte development has the potential to serve as a source of systematic characters for coralline algae.

Comparing the pulp/tooth area ratio and dentin thickness of mandibular first molars in different age groups: A cone-beam computed tomography study.

Context:Mandibular first molar frequently requires endodontic treatment. Understanding age-related changes in pulp-dentin complex and root canal morphologies is essential for successful endodontic and restorative treatments.Aim:This study aimed to compare pulp/tooth area ratio (PTAR) and dentin thickness (DT) in mandibular first molars in different age groups through cone-beam computed tomography (CBCT) imaging.Subjects and Methods:One hundred CBCT images of mandibular first molar were divided into five groups; age 20–29, 30–39, 40–49, 50–59, and 60 years old and older. Axial images were used to determine PTAR at Level A (furcation), Level B (between Levels A and C), and Level C (half distance between the furcation and apex of the root). The minimum DT of the distal wall of mesiobuccal (MB) and mesiolingual (MLi) canal and mesial wall of distal canal at 2 and 3 mm under the furcation was measured.Statistical Analysis Used:Analysis of variance was used to determine differences among age groups.Results:PTAR was determined to reduce as age increases, showing a significant difference among the age groups at Levels A, B, and C of both roots (P < 0.05). The minimum DT was found to increase with age, demonstrating a significant difference among the age groups of MB and MLi canal at 2 and 3 mm (P < 0.05). No statistically significant difference was observed in the mesial DT of distal canal.Conclusions:The reduction of PTAR and the increasing DT were confirmed with advanced age.

Primary esophageal tuberculosis: a case report

A 60-year-old woman born in Tarma and living in Lima, with a history of biomass exposure, contact with a patient with tuberculosis, arterial hypertension, heart arrhythmia and mother with ovarian cancer, visited the medical center with progressive dysphagia, 15-kilogram weight loss and evening fever for seven months. A previous endoscopy revealed an esophageal tumor. A CT scan showed middle and distal third esophageal wall thickening, and 10x10 mm mediastinal adenopathies. The rest of the thoracic and abdominal organs were normal. The last endoscopy revealed an ulcerated lesion in the esophagus. The pathological evaluation showed a large chronic granulomatous inflammation with giant cells and necrosis. Ziehl–Neelsen stain was negative for Koch bacillus and revealed no malignant lesion. A Mycobacterium tuberculosis-positive polymerase chain reaction (PCR) was observed. An adenopathy biopsy was performed by endoscopic ultrasound and PCR outcome was negative for Mycobacterium tuberculosis. In conclusion, primary esophageal tuberculosis was diagnosed and a specific treatment with a weight-adjusted dose was initiated.

Platelet-rich plasma administration to the lower anterior vaginal wall to improve female sexuality satisfaction.

Objective:To investigate the effect of platelet-rich plasma (PRP) injection to the lower one-third of the anterior vaginal wall on sexual function, orgasm, and genital perception in women with sexual dysfunction.Materials and Methods:Four sessions of PRP were administered to the anterior vaginal wall of 52 female patients with sexual dysfunction and orgasmic disorder [Female Sexual Function Index (FSFI) total score ≤26 orgasmic subdomain score ≤3.75]. Prior to the PRP administrations in each session, the FSFI validated in Turkish, the Female Genital Self-Image Scale (FGSIS), the Female Sexual Distress Scale-Revised (FSDS-R), and Rosenberg’s Self-Esteem Scale were used and in the final follow-up, and the Patient Global Impression of Improvement (PGI-I) was performed and the results were analyzed.Results:Following the application of the PRP, the total FSFI score was observed as 27.88±4.80 and the total score was 26 and above in 50% of the patients (p<0.001). Orgasm subdomain scores were found as 2.11±1.20 before the PRP treatment and 4.48±1.14 afterwards (p<0.001). A significant change was observed in all sub-domains after PRP and it was observed that this change started after the first administration (p<0.001). A statistically significant increase was determined in FGSIS genital perception scores, which was significant between the 1st and 2nd months (p<0.001). The FSDS-R scores showed a minimal increase in stress scores as the application number increased, but a statistically significant decrease was observed in the 4th administration (p<0.001). No statistically significant difference was found in Rosenberg Scale scores before and after treatment (p=0.389). High satisfaction was found in PGI-I scores.Conclusion:As a minimally invasive method, PRP administration to the distal anterior vaginal wall may improve female sexuality with high satisfaction.

Comparative Evaluation of the Internal and Marginal Adaptations of CAD/CAM Endocrowns and Crowns Fabricated from Three Different Materials.

To evaluate and compare the internal and marginal adaptations of chairside CAD/CAM (CEREC) endocrowns and crowns fabricated from lithium disilicate glass-ceramic (IPS e.max CAD), zirconia-reinforced lithium silicate glass-ceramic (VITA Suprinity), and hybrid ceramic (VITA Enamic). Dental models of the two first maxillary molars were selected. One was prepared for an endocrown, and the other for a standard all-ceramic crown. A total of 72 CAD/CAM restorations, including 36 endocrowns and 36 crowns made of IPS e.max CAD, VITA Suprinity, and VITA Enamic (n = 12 each), were fabricated. Discrepancies were measured in the buccal, mesial, lingual, and distal aspects of three sites (marginal, mid-axial wall, and occlusal/floor) using the noncontact ATOS scanner. Statistical analysis was performed using MANOVA and between-subject effects tests (α = .05). Mesial axial wall discrepancy was significantly lower in endocrowns compared to occlusal discrepancy in crowns, while distal axial wall discrepancy was significantly higher. Moreover, floor discrepancy was found to be significantly lower in endocrowns compared to crowns. However, type of material had no significant effect on any kind of discrepancy. The marginal and internal adaptation values were within a clinically acceptable range for both kinds of restoration and all three materials. However, restoration type (crown vs endocrown) was significantly different in the mesial and distal axial wall and occlusal/floor discrepancies, regardless of restoration material.