To the Editor.— We would like to report a case with a mild polyuria during his first exposure to methoxyflurane but a more severe and protracted episode of renal dysfunction during a second. Report of a Case.— A 43-year-old white man was seen on Dec 12, 1969, with increasing arterial claudication of the left leg of several years' duration. There was no history of renal or hepatic disease. Results of physical examination were normal except for absent left popliteal and dorsalis pedis pulses. The patient underwent a four-hour surgical procedure with a No. 10 Dacron graft being placed between the distal aorta and left external iliac artery while he was under 0.2% methoxyflurane and nitrous oxide anethesia. The patient did not require transfusion and was not hypotensive during the procedure. Following surgery the urine output increased to 4 to 5 liters a day for the next four days, after which
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