The current intelligent diagnosis and prediction methods for transformer faults are prone to low diagnostic accuracy and insufficient trend prediction ability when the fault categories are imbalanced. Therefore, a fault diagnosis and prediction model for transformers was constructed using a deep learning framework. The fault diagnosis model was constructed using a focus loss stack sparse noise reduction autoencoder on the deep learning framework. The prediction model was constructed by fusing long and short term memory networks on the basis of tree structure Parzen optimization, and the two models were validated. The results obtained through validation of the diagnostic model indicate that, when the actual hidden layer is set to 3 and the quantity of neurons is 58, the model accuracy during training and testing reaches 97.5% and 92.5% respectively. After adding 0.001 times the Gaussian white noise, the model accuracy was significantly lifted, so this study set the Gaussian noise coefficient to 0.001. In the comparison with baseline models, the actual classification ability of the research model samples is strong, significantly improving the fault diagnosis ability. In the validation of the prediction model, the three error index values of the research model in the single prediction step of CH4 concentration were 0.0699, 0.0540, and 0.8481%, respectively, and proved to be were lower than in the case of the baseline model. The three error values in the two-step prediction are 0.0194, 0.0161, and 0.6535%, which are also lower than in case of the baseline model. Overall, the diagnosis and prediction model proposed in this paper can provide real-time future numerical predictions of dissolved gas analysis and monitoring data in transformer oil. Furthermore, the research outilnes the future development trend of monitoring and measurement through application of tensor flow deep learning framework in transformer fault diagnosis. The attained prediction results are innovative, and could well complete the purpose of actual transformer fault diagnosis and early warning.