The aim of this paper is a theoretical reflection which attempt is to define the breakthrough and disruptive innovation phenomena. For many years, scholars have studied the different forms of innovation and have provided new definitions and proposed different approaches to this topic. An issue discussed in this work is the differences between disruptive and breakthrough innovations, which can be perceived as similar but are producing different effects in the industry and market structure, and as well in the product structure and the technological approach to develop an innovation. This paper aims to develop a univocal meaning in the literature, differentiating the two phenomena, and provides a framework for the analysis of the different forms of technological change, studying its pervasive influence on our economy.