Disruption Of Continuity Research Articles

Unveiling the Role of PEO-Capped TiO2 Nanofiller in Stabilizing the Anode Interface in Lithium Metal Batteries.

Lithium metal batteries (LMBs) will be a breakthrough in automotive applications, but they require the development of next-generation solid-state electrolytes (SSEs) to stabilize the anode interface. Polymer-in-ceramic PEO/TiO2 nanocomposite SSEs show outstanding properties, allowing unprecedented LMBs durability and self-healing capabilities. However, the mechanism underlying the inhibition/delay of dendrite growth is not well understood. In fact, the inorganic phase could act as both a chemical and a mechanical barrier to dendrite propagation. Combining advanced in situ and ex situ experimental techniques, we demonstrate that oligo(ethylene oxide)-capped TiO2, although chemically inert toward lithium metal, imparts SSE with mechanical and dynamical properties particularly favorable for application. The self-healing characteristics are due to the interplay between mechanical robustness and high local polymer mobility which promotes the disruption of the electric continuity of the lithium dendrites (razor effect).

Safety of third dose of COVID-19 vaccination in frail patients: Results from the prospective Italian VAX4FRAIL study.

Despite people with impaired immune competence due to an underlying disease or ongoing therapy, hereinafter frail patients, are (likely to be) the first to be vaccinated, they were usually excluded from clinical trials. To report adverse reactions of frail patients after receipt of the third dose (booster) administered after completion of a two-dose mRNA vaccination and to compare with those reported after the receipt of the first two doses. A multicenter, observational, prospective study aimed at evaluating both the safety profile and the immune response of Pfizer-BioNTech or Moderna vaccines in frail patients. National Project on Vaccines, COVID-19 and Frail Patients (VAX4FRAIL). People consenting and included in the VAX4FRAIL trial. A series of three doses of COVID-19 mRNA vaccination from the same manufacturer. Evaluation of a self-assessment questionnaire addressing a predefined list of eight symptoms on a five-item Likert scale. Symptoms were classified as severe if the patient rated them as severe or overwhelming. Among 320 VAX4FRAIL participants diagnosed/treated for hematological malignancies (N=105; 32.8%), solid tumors (N=48; 15.0%), immune-rheumatological diseases (N=60; 18.8%), neurological diseases (N=107; 33.4%), and receiving the booster dose, 70.3% reported at least one loco-regional or systemic reactions. Adverse events were mostly mild or moderate, none being life-threatening. Only six of the 320 (1.9%) patients had their treatment postponed due to the vaccine. The safety profile of the booster compared to previously administered two doses showed a stable prevalence of patients with one or more adverse events (73.5%, 79.7% and 73.9% respectively), and a slightly increment of patients with one or more severe adverse events (13.4%, 13.9% and 19.2% respectively). The booster of the mRNA COVID-19 vaccine was safely administered in the largest prospective cohort of frail patients reported so far. VAX4FRAIL will continue to monitor the safety of additional vaccine doses, especially systemic adverse events that can be easily prevented to avoid interruption of continuity of care. https://clinicaltrials.gov/ct2/show/NCT04848493, identifier NCT04848493.

Leveraging artificial intelligence to optimize COVID-19 robust spread and vaccination roll-out strategies in Southern Africa.

The outbreak of coronavirus in the year 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prompted widespread illness, death, and extended economic devastation worldwide. In response, numerous countries, including Botswana and South Africa, instituted various clinical public health (CPH) strategies to mitigate and control the disease. However, the emergence of variants of concern (VOC), vaccine hesitancy, morbidity, inadequate and inequitable vaccine supply, and ineffective vaccine roll-out strategies caused continuous disruption of essential services. Based on Botswana and South Africa hospitalization and mortality data, we studied the impact of age and gender on disease severity. Comparative analysis was performed between the two countries to establish a vaccination strategy that could complement the existing CPH strategies. To optimize the vaccination roll-out strategy, artificial intelligence was used to identify the population groups in need of insufficient vaccines. We found that COVID-19 was associated with several comorbidities. However, hypertension and diabetes were more severe and common in both countries. The elderly population aged ≥60 years had 70% of major COVID-19 comorbidities; thus, they should be prioritized for vaccination. Moreover, we found that the Botswana and South Africa populations had similar COVID-19 mortality rates. Hence, our findings should be extended to the rest of Southern African countries since the population in this region have similar demographic and disease characteristics.

S1675 Blame It on the Bamboo Stump: A Pancreatic Ductal Disruption Successfully Managed With Two-Step Endoscopic Therapy

Introduction: Non-penetrating, isolated pancreatic injuries are rare, and the management is not well-established and challenging. Most injuries are managed by surgery, but recently several case reports discuss endoscopic therapy for treatment of main pancreatic duct disruption. We report a case of pancreatic injury from falling on a bamboo stump with complete pancreatic ductal disruption and complete pancreas divisum with a dominant dorsal duct that was successfully nonoperatively managed through endoscopic therapy. Case Description/Methods: An 18-year-old male transferred for worsening abdominal pain from a grade IV pancreatic injury complicated by pancreatic ascites and massive pancreatic fluid collections (PFCs) sustained a month prior after a non-penetrating fall onto a bamboo rod in the Caribbean. He had failed conservative therapy and 2 attempts with ERCP for pancreatic duct (PD) stent placement. CT A/P and MRCP showed a 13cm cyst consistent with hemorrhagic pancreatic pseudocyst (Figure A-B). Labs showed leukocytosis, elevated lipase and LFTs, but he was hemodynamically stable. US-guided paracentesis drained 250mL of fluid consistent with pancreatic ascites. To allow for pancreatic edema reduction, we elected for a 2-step procedure with separate EUS and ERCP. EUS showed multiple PFCs s/P endoscopic cyst-gastrostomy with Axios stent (Figure C-D). Repeat CT A/P showed decrease in size of the PFCs (Figure E). He was discharged and returned in one week for ERCP that revealed a surprising complete pancreas divisum and total disrupted main dorsal PD, which was endoscopically treated with sphincterotomy of the minor papilla and a long PD stent across the disruption (Figure F-H). The Axios stent was removed a week later, and 4 weeks later we successfully removed the PD stents from both the major and minor papillae. He made an uneventful recovery and remains well. Discussion: Pancreatic disruption syndrome or Disconnected Pancreatic Duct Syndrome (DPDS) is an interruption of pancreatic duct continuity, usually from necrotizing pancreatitis, but can occur with blunt or penetrating abdominal injury, as in our patient. Endoscopic management is a minimally invasive option for DPDS and pancreatic ascites. Our patient had severe pancreatic injury managed using 2-stage endoscopic therapy, demonstrating a successful treatment strategy for pancreatic injury with total main DPDS. Further studies are required regarding the selection of patients, safety, and long-term outcomes.Figure 1.: Image A: CT A/P (coronal) demonstrating edematous pancreas with significant peripancreatic fat stranding, with a peripherally enhancing hypodense fluid collection near the body and tail of the pancreas measuring approximately 4.0 x 4.8 x 13 cm in the maximum AP, RL and SI dimensions (red arrow). Image B: MRCP (coronal) Abutting the pancreatic body is a multilobulated rim-enhancing complex fluid collection that extends from the level of the diaphragmatic hiatus to just above the level of the aortoiliac bifurcation and measures 6.8 x 9.7 x 19.1 cm (AP by TR by SI, red arrow). Image C-D: EUS demonstrating large pancreatic fluid collection (PFC, left) and s/P Axios cyst-gastrostomy (right). Image E: CT A/P (coronal) demonstrating cyst-gastrostomy placement with interval decrease in PFC. Image F-H: Pancreatogram showed extravastion of contrast material at the junction of proximal 2/3 and distal1/3 of the dorsal PD c/w disrupted dorsal PD (Complete Pancreas divisum, left). Placement of a 5 Fr 9 cm Zimmon PD stent with pigtail crossing the disruption at the minor papilla (center). Pancreatogram showing no extravasation of contrast material s/P PD stent placement.

Continuity of physician care over the last year of life for different cause-of-death categories: a retrospective population-based study.

The mix of care provided by family physicians, specialists and palliative care physicians can vary by the illnesses leading to death, which may result in disruptions of continuity of care at the end of life. We measured continuity of outpatient physician care in the last year of life across differing causes of death and assessed factors associated with higher continuity. We conducted a retrospective descriptive study of adults who died in Ontario between 2013 and 2018, using linked provincial health administrative data. We calculated 3 measures of continuity (usual provider, Bice-Boxerman and sequential continuity), which range from 0 to 1, from outpatient physician visits over the last year of life for terminal illness, organ failure, frailty, sudden death and other causes of death. We used multivariable logistic regression models to evaluate associations between characteristics and a continuity score of 0.5 or greater. Among the 417 628 decedents, we found that mean usual provider, Bice-Boxerman and sequential continuity indices were 0.37, 0.30 and 0.37, respectively, with continuity being the lowest for those with terminal illness (0.27, 0.23 and 0.33, respectively). Higher number of comorbidities, higher neighbourhood income quintile and all non-sudden death categories were associated with lower continuity. We found that continuity of physician care in the last year of life was low, especially in those with cancer. Further research is needed to validate measures of continuity against end-of-life health care outcomes.

The Effects of Fragmented and Continuous Interruptions on Online Task Performance

This study examines the effect of online interruptions on task performance. Two hundred and eighty players played a game designed to simulate an online environment decision-making process. The manipulation was achieved through an intervention design. Participants were exposed to messages in six interruption conditions as they played: (i) slow-fragmented text, (ii) fast-fragmented text, (iii) slow-fragmented image, (iv) fast-fragmented image, (v) continuous text, and (vi) continuous image. We compared text-only interruptions and image interruptions within different rates of interruption. The results indicate that participants with continuous text interruptions display the same performance as those without interruptions; participants who experience fast text interruptions perform the best; participants exposed to slow text interruptions performed poorly on tasks. These results imply the conditions in which controlling the rate and richness of online interruptions could improve task performance.

Proteomic Analysis of the Sphincter in a Neurogenic Bladder Caused by T10 Spinal Cord Injury.

This study aimed to conduct proteomic analysis of the sphincter in a neurogenic bladder caused by T10 spinal cord injury. The differentially expressed proteins (DEPs) of the sphincters (internal urethral sphincter) in the neurogenic bladders (NBs) of rats after complete transection of the T10 spinal cord segment were screened using tandem mass tag (TMT)-based quantitative labeling, and their biological information was analyzed. Twelve adult Sprague Dawley rats out of 40 were randomly assigned to the blank group (n = 12), while the remaining 28 were placed in the T10 spinal cord injury model via modified Hassan Shaker spinal cord transection; 12 of these rats were then randomly selected as the model group. The rats in both groups underwent urodynamics detection and hematoxylin and eosin (H&E) staining. The proteins expressed in the bladder sphincter were detected using TMT-based quantitative proteomics. DEPs were defined as proteins with fold change >1.5 or <1/1.5, p < 0.05, and unique peptide ≥2. The DEPs were subjected to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis using KOBAS 3.0., and gene ontology functional annotation analysis was performed using the Cytoscape 3.7.1. BiNGO plug-in. The protein-protein interaction network was then constructed using the interactive gene-retrieval tool STRING and Cytoscape software. The leak-point pressure and maximum cystometric volume in the model group were significantly higher than those in the blank group (p < 0.01), and H&E staining showed continuous interruption of the bladder sphincter fibers in the model group. A total of 250 DEPs were screened in the bladder sphincter, 83 of which were up-regulated and 167 of which were down-regulated. KEGG analysis of the DEPs was used to screen 15 pathways, including metabolic pathways, extracellular matrix (ECM)-receptor interaction, adhesion spots, the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, the cytochalasin signaling pathway, and the advanced glycation end-products (AGE)/receptor for AGEs (RAGE) signaling pathway in diabetic complications and vascular smooth muscle contraction. It is of great significance to explore the pathological mechanism of non-inhibitory contraction of the bladder sphincter caused by spinal cord injury above the T10 segment from the perspective of ECM-receptor interaction, focal adhesion-activated PI3K/Akt signaling pathway, and cell relaxation signaling pathways. Synaptic vesicle glycoprotein (Sv2A) involved in the release of neurotransmitters from synaptic vesicles, arrestin β2 inhibitory proteins involved in α-adrenergic receptors and G-protein-coupled receptor internalization, and calmodulin and calmodulin binding protein involved in calcium-sensitive signaling pathways may be potential targets for developing new ways to treat bladder sphincter overactivity caused by T10 spinal cord injury.

Diagnosis and treatment of a maxillary lateral incisor with two root canals. A case report.

Although endodontic treatment has shown high success rates, the factors involved in the failure cases are still being studied. In this sense, the complexity of interradicular anatomy may lead to inadequate instrumentation and the persistence of etiological factors related to apical periodontitis and endodontic failure. The present case report illustrates the occurrence, diagnosis and nonsurgical endodontic treatment of a maxillary lateral incisor with two canals. A 24-year-old Peruvian woman was referred complaining of darkening of the upper front tooth. After clinical examination, the patient was diagnosed with necrotic pulp and asymptomatic apical periodontitis. Still, radiographic examination revealed a disruption in the canal continuity, leading to a suspicion of unusual root canal morphology in the maxillary lateral incisor. By taking radiographs from different angles, according to the technique described by Clark, the presence of two independent canals was verified. Since most cases of endodontic failure are due to untreated canals, a predictable endodontic therapy must achieve the removal and neutralisation of etiologic factors related to periapical infiltration. The occurrence of additional root canals requires a correct interpretation of radiographic images to detect these variants and take the necessary considerations for proper endodontic treatment.

The Scarcities ofUdolpho

AbstractThis essay identifies symptoms of the historical emergence of generalized scarcity in Ann Radcliffe's Mysteries of Udolpho, which grants scarcity's ruthless logic a primary narrative function under the aesthetic cover of suspense. Radcliffe's novels generate occult phenomenologies of scarcity, which manifest as affect, epistemic structure, economic process, social relations, and transcendent force or metaphysic (both natural and supernatural). Suspense replicates the social operation of generalized scarcity by carrying us from one particular “conflict of choice” to the next, keeping a veil over the governing logic that conditions the whole process. If we treat crises as unpredictable and singular events rather than effects of identifiable systems, we avoid reckoning with capitalism's normalization of continual disruption and reorganization, what Marx called its “constant revolutionising of production, [and] uninterrupted disturbance of all social conditions.” The scarcity-inflected narrative apparatus privileges personal volition—individual choices that lead to specific outcomes—over collective or systemic determinations, a distinction key to the coercive social power of scarcity. It is not just Radcliffean gothic but narrative in general that comes under the sway of this logic during the last decade of the eighteenth century.

Disruption of Sleep Continuity During the Perimenopause: Associations with Female Reproductive Hormone Profiles.

Nocturnal vasomotor symptoms (nVMS), depressive symptoms (DepSx), and female reproductive hormone changes contribute to perimenopause-associated disruption in sleep continuity. Hormonal changes underlie both nVMS and DepSx. However, their association with sleep continuity parameters resulting in perimenopause-associated sleep disruption remains unclear. We aimed to determine the association between female reproductive hormones and perimenopausal sleep discontinuity independent of nVMS and DepSx. Daily sleep and VMS diaries, and weekly serum assays of female reproductive hormones were obtained for 8 consecutive weeks in 45 perimenopausal women with mild DepSx but no primary sleep disorder. Generalized estimating equations were used to examine associations of estradiol, progesterone, and follicle stimulating hormone (FSH) with mean number of nightly awakenings, wakefulness after sleep onset (WASO) and sleep-onset latency (SOL) adjusting for nVMS and DepSx. Sleep disruption was common (median 1.5 awakenings/night, WASO 24.3 and SOL 20.0 minutes). More awakenings were associated with estradiol levels in the postmenopausal range (β = 0.14; 95% CI, 0.04 to 0.24; P = 0.007), and higher FSH levels (β [1-unit increase] = 0.12; 95% CI, 0.02 to 0.22; P = 0.02), but not with progesterone (β [1-unit increase] = -0.02; 95% CI, -0.06 to 0.01; P = 0.20) in adjusted models. Female reproductive hormones were not associated with WASO or SOL. Associations of more awakenings with lower estradiol and higher FSH levels provide support for a perimenopause-associated sleep discontinuity condition that is linked with female reproductive hormone changes, independent of nVMS and DepSx.

GNSS/Accelerometer Adaptive Coupled Landslide Deformation Monitoring Technology

Global Navigation Satellite System (GNSS) positioning technology has become the most effective method for real-time three-dimensional landslide monitoring. However, the GNSS observation signal is easily affected by the presence of a complex landslide environment with high occlusion and strong interference, in which case its accuracy and reliability cannot meet the requirements of landslide deformation monitoring. Although the accelerometers have strong autonomous working capacities and can complement the GNSS landslide monitoring technology, regular GNSS/accelerometer coupled deformation monitoring technology relies on high-quality GNSS measurement information in order to obtain high-precision accelerometer-reckoned results, derived by accurately estimating the baseline shift error (BSE). When the GNSS signal suffers severe interference, the GNSS monitoring error will be partially absorbed by the BSE component after Kalman filtering, resulting in the divergence of the deformation solution. In this study, an abnormal observation variance inflation model was used to process the simulated landslide monitoring data (GNSS and accelerometer raw observation) for three typical scenes—GNSS signal normally locked, signal partially lost, and short-term interruption. The results were as follows: (1) When the GNSS signal was normally locked, the accuracy was comparable to that of the coupled solution employing an accelerometer (the Root Mean Square (RMS) values in the East (E), North (N) and Upward (U) directions were 0.11 cm, 0.33 cm, and 0.30 cm, respectively). (2) When the GNSS signal was partially lost, the accelerometer could effectively suppress the low-precision float solution of the GNSS, but here, the accuracy of the coupled solution would also decrease with the duration of the floats (the RMS values were E—1.21 cm, N—0.31 cm, and U: 0.58—cm, respectively, when the floats lasted for 10 s, and increased to E—3.09 cm, N—0.39 cm, and U—1.14 cm when they lasted for 20 s, wherein E was the main simulated sliding direction). (3) When the GNSS signal was interrupted for a short time, the accuracy of the coupled solution gradually decreased during continuous interruption, and decreased more quickly during the sliding period of the landslide (when the interruption persisted for 10 s, the RMS values in the simulated landslide stability period were E—0.61 cm, N—0.24 cm, and U—0.25 cm, respectively, while in the simulated landslide sliding period they reached E—4.10 cm, N—6.84 cm, and U—2.30 cm). However, raw observations of the accelerometer could still effectively be used to assist in identifying the real state of the landslide, thereby providing auxiliary information pertinent to early landslide disaster warning.

Increased variability in total sleep time is associated with reduced psychomotor vigilance impairment following experimental sleep continuity disruption

Increased variability in total sleep time is associated with reduced psychomotor vigilance impairment following experimental sleep continuity disruption

Molecular dynamics study of water and ion behaviors of mixed salts solutions on extended quartz surface

The adoption and evolution of water molecules and ions in mixed electrolytes at the surface play vital roles in the physical properties and chemical reactions of SiO2-like corrosion. The effect of salt type and concentration on the structure and dynamics of water molecules and ions at silica surfaces are studied using all-atom molecular dynamics simulations taking the case of the NaCl, MgCl2, and NaCl–MgCl2 aqueous solutions. The ability of ion hydration is in the order of Mg2+ &amp;gt; Na+ &amp;gt; Cl−, being opposite to their hydration Gibbs free energies, which directly influence the weak interaction in the solution and the diffusion rate of the particles. Mg shows stronger destruction to weak interactions than Na does, and ionic hydration of Mg2+ decelerates the self-diffusion coefficient of water molecules significantly due to the enhanced Coulomb effect and the interruption of solution continuity. Meanwhile, the self-diffusion coefficient of particles decreases with the concentration improvement in the single salt solution as increased ionic hydration. In the mixed salt solution, the order of diffusion rate is Cl− &amp;gt; Na+ &amp;gt; Mg2+ as a result of the different confinement effects of the protonated pore. Interestingly, a small amount of Na+ addition can promote the self-diffusion of Mg2+, but a great many of Na+ addition slows the diffusion of Mg2+. This work provides comprehensive insight into the behavior of mixed salt solutions at silica surfaces, shedding light on the practical applications of geological sciences, cultural relics protection, and colloidal sciences.

Систематизированный подход в оценке уретероскопических осложнений.

Introduction. Currently, ureteroscopy has become the method of choice for the treatment of patients with ureter stone location in lower third and middle third. Regardless of the fact that ureteroscopy is an endoscopic, minimally invasive intervention, it is associated with intraoperative complications. Purpose. The main objective of this literature review is to objectify the existing scales of ureter injury, demonstrate evolutionary changes from simple to more detailed, evaluate their advantages and disadvantages, and select the optimal and reproducible tool for assessing postureteroscopic complications. Materials and methods. In this literature review, we used research materials on existing scales of ureter injury published in the databases PubMed, the scientific electronic library of Russia (eLibrary), Scopus, EMBASE, websites of professional associations. Such keywords were used for searching: «postureteroscopic complications», «intraoperative complications of ureteroscopy», «ureteral injuries». This review focuses on the currently existing scales that assess ureteral injury, which can be universal and used in everyday practice. After a detailed check of the reliability of sources, the impact factors of journals and the sequence of presentation of the material, 28 sources were selected directly for citation. Results. According to literature review, historical and present-day knowledge of using postureteroscopic lesion scales in various surgical centers are presented here. Most of scales are focus on disruption of anatomical continuity of the ureter or on complications that develop during the implementation of surgical treatment, which are not specific for this procedure. However, the most detailed description of postureteroscopic complications makes it possible to distinguish between «complicated» and «uncomplicated» ureteroscopy. Conclusion. Thus, PULS scoring system is a standardized and easily reproducible tool in the evaluation of postureteroscopic complications. The emergence of new scales only emphasizes the importance and need for additional prospective and multicenter studies.

Novel compound heterozygous cadherin 3 mutations in hypotrichosis and juvenile macular dystrophy.

Novel compound heterozygous cadherin 3 mutations in hypotrichosis and juvenile macular dystrophy.

Disruptions in Relational Continuity: The Impact of Pandemic Public Health Measures on Families in Long-Term Care.

Although the value of family caregivers' involvement with relatives in long-term care (LTC) is well recognized, tensions remain regarding their role. Such tensions were exacerbated during the COVID-19 pandemic as strict public health measures restricted family access to LTC homes. Using interpretive description, we examined the impact of visitation restrictions on family caregivers' experiences caring for a relative in LTC between March 2020 and June 2021. In-depth interviews were conducted with 14 family caregivers (five spouses and nine adult daughters) and two key themes were identified. The first theme, "seeking to maintain relational continuity," illustrates how caregivers sought to sustain connections with residents prior to and during the pandemic. The second theme, "disrupted relational continuity," highlights the impact of severed relational connections on caregivers' sense of self and ongoing feelings of loss and anger. Findings call for a trauma-informed approach that recognizes the pervasiveness of trauma for family caregivers and the avoidance of re-traumatization.

Referring patients with suspected lung cancer: a qualitative study with primary healthcare professionals in Ireland.

Lung cancer is the leading cause of cancer death globally. Most cases are diagnosed late. Primary healthcare professionals are often the first point of contact for symptoms of concern. This study explored primary healthcare professionals’ experience of referring individuals with signs and symptoms suggestive of lung cancer along the appropriate healthcare pathway and explored strategies to help primary healthcare professionals detect lung cancer early. Focus groups and individual interviews were conducted with 36 general practitioners, community pharmacists, practice nurses, and public health nurses. Data were analysed thematically. Participants identified typical lung cancer signs and symptoms such as cough and coughing up blood (i.e., haemoptysis) as triggers for referral. Atypical/non-specific signs and symptoms such as back pain, pallor, and abnormal blood tests were perceived as difficult to interpret. Participants often refrained from using the word ‘cancer’ during conversations with patients. Ireland’s Rapid Access Lung Clinics were perceived as underused, with some general practitioners referring patients to these clinics only when clear and definitive lung cancer signs and symptoms are noted. Lack of communication and the resulting disruption in continuity of care for patients with suspected lung cancer were highlighted as healthcare system flaws. Education on early referral can be in the form of communications from professional organizations, webinars, interdisciplinary meetings, education by lung specialists, and patient testimonials. Lung cancer referral checklists and algorithms should be simple, clear, and visually appealing, either developed as standalone tools or embedded into existing primary care software/programmes.

The Value of Transrectal Ultrasound in the Preoperative Diagnosis of Complex Anal Fistula (CAF): Based on a Retrospective Cohort Study.

The Value of Transrectal Ultrasound in the Preoperative Diagnosis of Complex Anal Fistula (CAF): Based on a Retrospective Cohort Study.

The effect of sleep continuity disruption on multimodal emotion processing and regulation: a laboratory-based, randomised, controlled experiment in good sleepers.

Previous research shows that experimental sleep deprivation alters emotion processing, suggesting a potential mechanism linking sleep disruption to mental ill-health. Extending previous work, we experimentally disrupted sleep continuity in good sleepers and assessed next-day emotion processing and regulation using tasks with established sensitivity to depression. In a laboratory-based study, 51 good sleepers (37 female; mean [SD] age 24[3.63]years), were randomised to 1 night of uninterrupted sleep (n=24) or sleep continuity disruption (n=27). We assessed emotion perception, attention, and memory the following day. Participants also completed an emotion regulation task and measures of self-reported affect, anxiety, sleepiness, overnight declarative memory consolidation, and psychomotor vigilance. Confirming the effects of the manipulation, sleep continuity disruption led to a marked decrease in polysomnography-defined total sleep time (229.98 versus 434.57 min), increased wake-time after sleep onset (260.66 versus 23.84 min), and increased sleepiness (d=0.81). Sleep continuity disruption led to increased anxiety (d=0.68), decreased positive affect (d=-0.62), reduced overnight declarative memory consolidation (d=-1.08), and reduced psychomotor vigilance (longer reaction times [d=0.64] and more lapses [d=0.74]), relative to control. However, contrary to our hypotheses, experimental sleep disruption had no effect on perception of, or bias for, emotional facial expressions, emotional memory for words, or emotion regulation following worry induction. In conclusion, 1 night of sleep continuity disruption had no appreciable effect on objective measures of emotion processing or emotion regulation in response to worry induction, despite clear effects on memory consolidation, vigilance, and self-reported affect and anxiety.

From “Crisis” to “Opportunity”: Israeli Social Service Nonprofits’ Responses to COVID-19

ABSTRACT Nonprofit organizations operating in civil society have become the main channel for social service provision in most neoliberal welfare economies. Social service nonprofits (SSNs) deliver essential services mainly to vulnerable and marginalized populations. Since the outbreak of COVID-19, SSNs have been at the frontline of dealing with its socioeconomic consequences. This paper focuses on the activities and responses to the crisis of SSNs in Israel. Interviews with SSN directors (N = 17) show that they dealt with growing demands for services due to the social implications of the pandemic, along with operational difficulties, such as deterioration in clients’ condition, disruption in service continuity, and reduced funding and staff. Next to these difficulties, the findings highlighted the social innovations adopted by SSNs to maintain service provision, such as implementing remote service technologies, forming collaborations, and recruiting volunteers. Implications for the social services and policies are presented and discussed.