Abstract Twenty worker ants from laboratory colonies of the red imported fire ant (RIFA) starved for 14 days were placed in 30-ml disposable plastic cups modified to provide a humid environment. Candidate chemicals were dissolved in once refined soybean oil (SBO) and presented to the ants on a cotton swab placed in a vial cap that was then placed in 1 of the cups. The ants were allowed to feed on the treated SBO for 24 h, after which, the treated cotton swabs were removed. After another 24 h fresh vial caps with untreatd SBO saturated cotton swabs were made available to the ants for the duration of the test. Mortality counts were made at intervals of 1, 2, 3, 6, 8, 10 and 14 days after initial exposure. Each test consisted of 3 replications at 3 concentrations, 1.0, 0.1 and 0.01%. Room temperature was maintained at 26.7 ± 2.2°C. A SBO control and a mi rex standard were used in all tests. Based on encouraging USDA screening results for 3 fluon’nated alcohols (AI3-23780-23782) from several years ago, we tested 28 commercially available fluorinated compounds. Four compounds showed significant delayed toxicity at 1.0%; however, these compounds did not have activity at lower concentrations. Although none of the compounds tested appeared to be suitable fire ant toxicants, the results were encouraging and our laboratory is investigating other organofluorine compounds for toxicity against these ants.