Abstract This paper reports a novel amplified piezoelectric actuator featuring compliant displacement amplification mechanism of hybrid summation and multiplication. The hybrid amplification mechanism uses the concept of nesting a pair of Scott-Russell linkages into a toggle linkage to realize the hybrid amplification functions of summation and multiplication. Also, compliant amplification mechanisms with double output ports are designed, enhancing the flexibility of designs and applications. The hybrid displacement amplification principle is mathematically explained in detail. It is demonstrated based on finite element simulations that the displacement amplification ratio, output stiffness and resonance frequency of the proposed hybrid amplification mechanism of summation and multiplication outperform those of the classic rhombus-type and bridge-type compliant mechanisms. The experimental testing results of a prototype show that the amplified piezoelectric actuator is capable of providing 315 μm strokes with the displacement amplification ratio of 16.2. The fundamental resonance frequency with piezoelectric stacks mounted is 1218 Hz. Comparison to typical designs in literature shows well comprehensive performances of statics and dynamics, verifying the advantages of such a hybrid amplification mechanism of summation and multiplication.