A form of general dispersion relation for electromagnetic waves in a fully ionized anisotropic plasma with loss-cone that explicates the contribution of the loss-cone to the dispersion relation is developed. By initially ignoring effects due to anisotropy, it is shown by means of Nyquist diagram technique that an isotropic loss-cone distribution can be unstable to EM waves corresponding to the whistler mode (0<ω<Ω e ). The growth rate is then determined analytically for this distribution, assuming cyclotron resonance between the waves in the whistler mode and particles in the high energy tail of the velocity distribution. By including the effects of anisotropy, a general growth rate is obtained which is found to depend on the anisotropy, the size of the loss-cone, the softness of the energy spectrum, and the fraction of the particles which are resonant with the wave. For particular distributions the relative contributions of the anisotropy and of the loss-cone to the growth rate have been determined. It is seen that loss-cone effects, which depend on the size of the loss-cone as well as the softness of the energy spectrum, can be a significant factor in the determination of the growth rate. For the Lorentzian distribution, the half-width of unstable waves is considerably broadened and the growth rates are somewhat more severe as compared to a two-temperature Maxwellian. The threshold frequency is $$\omega _r \simeq \tfrac{8}{9}\Omega _e $$ which confirms the presence of unstable EM waves in the magnetospheric plasma leading to turbulence.
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