The reservoir group focusing on the Three Georges reservoir has been established in the upper Yangtze River, with a total regulation capacity of 51.5 billion m3. The reservoir group dispatch plays an important role in regulating the runoff. Economic activity in the Yangtze River estuary poses high requirements for water resources security. The water quality of main water supply reservoirs is influenced by the saltwater intrusion. The upstream reservoir group dispatch can enhance sea inlet runoff and mitigate saltwater intrusion hazard. In order to clarify the upstream reservoir group’s influence on the sea inlet water quantity in the Yangtze River estuary, the author designed three typical reservoir group dispatch scenarios to analyze flow rate change and different dispatch scenarios of Datong section. According to the findings, the upstream reservoir group dispatch is important to secure water quantity in the dry season. Through normal dispatch, the Three Georges reservoir can cut the days with a flow rate less than 100 million m3/s from 50.6 days to 8.8 days. In the special dry year, the sole emergency water supplement by the Yangtze River reservoir to the estuary will exert influence on the reservoir power generation. The joint operation of upstream reservoir group can basically eliminate such influence.