With the massive participation of new energy in the operation of distribution network (DN), the uncertainties arising from both load and renewable generation have brought challenges to its secure and reliable operation. In this paper, a model of day-ahead and intraday optimal scheduling based on dynamic partitioning (DP) of DN is constructed to realize the refinement of operation in both temporal and spatial dimensions, as well as to improve the reliability of system operation. For the strong fluctuation characteristics of the source-load in DN, the DP is achieved under the premise that the partition structure in each period is tight and the internal power supply has the ability to balance the power fluctuations. In order to improve the regional autonomy of DN, a day-ahead multi-objective optimal scheduling model is constructed based on the DP with the optimization objectives of weak inter-partition power coupling, lowest deficiency rate of flexibility, and lowest operating cost. And a scheme for articulation is proposed to ensure the effective guidance of day-ahead for intraday. Then the intraday dispatch model is constructed by shifting the focus to the incorporate characteristics of DP and quickly smooth the net load fluctuations. Finally, the performance and reliability of the proposed models are verified via case studies.