Reproductive problems pose a significant public health problem for women across all age groups, ethnic, and socioeconomic backgrounds. Women of color, women with few resources, women with limited education, and women from groups such as immigrants, and gay and lesbian who have traditionally faced discrimination, are disproportionately affected. By whatever definition one uses for race and ethnicity, unequal access to care, differences in the pathophysiology of disease, and a disparate response to treatment are all factors that collectively contribute to health disparities in women. Even physiologic processes such as puberty, ovulation, conception, and menopause vary between different ethnic and socioeconomic groups. Of note, reproductive problems are not solely a result of issues related to access to health care. Evidence from the medical literature supports disparities in infertility treatment outcomes and an increased prevalence of problems such as preterm birth, sexually transmitted infections, unintended pregnancy, uterine fibroids, and estrogen-deficiency states.1 In this issue of Seminars in Reproductive Medicine, we focus on these important disparities in reproductive health of women by considering health disparities across the lifespan of women. The guest editors believe preconception and pregnancy represent an unparalleled window of opportunity for intervention(s) that will impact not just the mother and infant but also future generations.