Introduction: Inflammatory bowel disease (IBD) affects all ethnicities worldwide. Studies have reported a high prevalence in Caucasians while African Americans have the lowest. Hispanics are the leading ethnic minority in the US, its importance to the healthcare system cannot be understated. The aim of this study was to assess the occurrence and other outcomes of IBD in Hispanics in the US using a national database. Methods: Case-control study using the NIS 2014, the largest publically available inpatient database in the US. All patients with ICD9 CM codes for Crohn's and UC were included. Hispanics were identified from the ethnic categories within the database. Population estimates were obtained from the U.S. National Census Bureau. The primary outcome was the occurrence and odds of IBD in Hispanics when compared to other ethnicities. Secondary outcomes were inpatient mortality, morbidity, measured by shock, ICU stay, multi-organ failure; resource utilization, measured by use of abdominal CT scan; length of hospital stay (LOS), hospitalization charges and costs. Propensity score matching was used to create a 1:1 matching population for gender, age and Charlson Comorbidity Index. Multivariate regression was used to adjust for income in patients' zip code, hospital region, location, size and teaching status. Results: A total of 319,390 patients with IBD were identified, of which 57,215 were propensity-matched to controls (17,815 Hispanic). The mean age was 44 and 56% were female. The prevalence of IBD in Hispanics was 32.8/100,000 persons (441.2/100,000 admissions), compared to 116.4/100,000 persons (962.9/100,000 admissions) of all other ethnicities. Prevalence and outcomes are displayed in Tables 1 and 2, respectively. On multivariate analysis, admitted Hispanics had OR:0.47 (p<0.01) of having IBD when compared to all other admitted ethnicities. Hispanics had higher odds of mortality, CT of the abdomen, hospital costs, and additional charges when compared to non-Hispanics. No other differences were noted. Conclusion: The national prevalence of IBD is lower in the Hispanic population compared to all other ethnicities. Interestingly we demonstrate a significant variation of additional costs, higher hospital charges, more imaging, and increased mortality for the Hispanic population. These differences may suggest the presence of social factors such as language barriers and lower socioeconomic status resulting in delayed medical evaluation and care or disparities in health insurance.713_A Figure 1. - Prevalence of IBD Stratified by Crohn's and UC.713_B Figure 2. - Resource utilization, odds of IBD stratified by UC and Crohn's disease, inpatient mortality and morbidity of admitted Hispanic patients compared to all other ethnicities.