The study of the immune status of the population living in polluted air is relevant, since air pollution caused by transport, industrial facilities adversely affect the state of health and respiratory organs. To conduct a comparative analysis of clinical and instrumental signs of respiratory system disorders in residents of the regions of Kyrgyzstan with varying degrees of air pollution. Research materials and methods: a study was made of the characteristics of atmospheric air in three areas of Kyrgyzstan: in the area of the village. Papan, in the area with. Gulbar of Aravan district and in the area of Osh city in according to GOST17.2.3.01-86. During analysis, dust content, nitrogen dioxide, sulfur dioxide, hydrogen sulfide, formaldehyde, carbon monoxide was determined. Atmospheric pollution significantly affects the human immune system, creating prerequisites for the development of diseases of the respiratory system and the cardiovascular system. Thus, a significant effect of atmospheric pollution on the human immune system has been established, the imbalance of the links of which creates prerequisites for development of respiratory system diseases and the cardiovascular system.