To explore the nursing intervention measures of microscopy-assisted anterior and posterior fusion in the treatment of lower cervical spine fracture and dislocation.46 patients with fracture and dislocation of lower cervical spine who were treated by microscope-assisted anterior and posterior fusion in our hospital from April 2018 to April 2019 were selected for this study, and divided into observation group and control group according to the different nursing interventions applied by the patients during the treatment. There were 23 patients in the two groups, while the patients in the control group were given routine nursing interventions. The patients in the observation group were given comprehensive nursing interventions. The curative effects of the treatment and nursing interventions in the two groups were observed, sorted out, analyzed and summarized. The changes of psychological status, recovery of spinal cord function, occurrence of complications and quality of life before and after nursing intervention were compared between the two groups.(l) Psychological status: Before nursing intervention, there was no significant difference in psychological status between the two groups, and there was no significant difference (P > 0.05); After nursing intervention, the SDS and SAS scores of patients in the observation group were better than those in the control group, and the difference was statistically significant (P < 0.05); (2) Recovery of spinal cord function: before nursing intervention, there was no significant difference in JOA scores of spinal cord function between the two groups, and the difference was not statistically significant (P > 0.05); After nursing intervention, JOA score of spinal cord function in the observation group was significantly better than that in the control group, the difference was statistically significant (P < 0.05); (3) Complication occurrence: Complication incidence in the observation group was lower than that in the control group, the difference was statistically significant (P < 0.05). (4) Quality of life: before nursing intervention, there was no significant difference in QOL scores between the two groups, and the difference was not statistically significant (P > 0.05); after nursing intervention, the QOL scores of patients in the observation group were better than those in the control group, and the difference was statistically significant (P < 0.05).Through the analysis, it was found that the operation of microscope-assisted anterior and posterior fusion therapy was more complicated and the risk of treatment was greater. The comprehensive nursing interventions throughout the preoperative, intraoperative and postoperative period played a vital role in improving the treatment effect of patients, which was not only conducive to the effective recovery of patients’ spinal cord function. At the same time, it can avoid complications in the treatment process, so as to promote the early recovery of the patient’s condition and improve the quality of life. In general, the application of comprehensive nursing interventions in the treatment of lower cervical spine fracture patients has higher application value, which is worthy of clinical vigorous promotion and.