Disk Drives Research Articles

Anaphylaxis in a country where Asia and Europe meet: Evaluation according to World Allergy Organization (WAO) and European Academy of Allergy and Clinical Immunology (EAACI) diagnostic criteria

BackgroundAnaphylaxis is an acute-onset, life-threatening clinical emergency involving more than one system. The World Allergy Organization (WAO) published anaphylaxis guidelines in 2020. The European Academy of Allergy and Clinical Immunology (EAACI) published anaphylaxis guidelines in 2021 and reviewed the diagnosis of anaphylaxis, risk factors, comorbid diseases, treatment management, and prevention studies.In this study, clinical features, demographic characteristics, risk factors, treatment management, and evaluations according to EAACI and WAO diagnostic criteria were analysed in patients diagnosed with anaphylaxis. In this way, it was aimed to provide a perspective on the diagnosis, etiology, and treatment management in patients with anaphylaxis and to open a window for new studies. MethodsWe retrospectively analysed the data recording system of patients who were evaluated with a history of systemic allergic reaction in the Allergy and Immunology outpatient clinic of our tertiary referral hospital in a ninety-month period between January 2016 and June 2023. The total number of patients admitted to our Allergy and Immunology Clinic between January 2016 and June 2023 was 14,9425. Among these patients, 1032 patients were evaluated in the outpatient clinic according to the ICD-10 (International Statistical Classification of Diseases and Related Health Problems) coding system and diagnosed as T78.2 Anaphylaxis by Allergy and Immunology Specialist. Each patient file was re-evaluated by the authors of the study and 689 eligible patients were included. ResultsIncluded in the study were 689 patients. The mean age of the patients was 46.2 ± 14.2 (35–57) years. 64.4% (n = 444) of the patients were female. Venom, drugs, and food were the 3 leading causes of anaphylaxis. In our study, younger age was determined as a statistically significant risk factor for food-induced anaphylaxis, female gender for drug-induced anaphylaxis and male gender for venom-induced anaphylaxis. (p < 0.001) If the cause of anaphylaxis can be identified, such as venom, drug or food, the frequency of anaphylaxis decreases statistically significantly compared to idiopathic anaphylaxis. (p < 0.001) The rate of acute hypotension, bronchospasm, or laryngeal involvement without skin involvement according to WAO and the rate of WAO severity classification grade 5 were significantly higher in patients who developed anaphylaxis due to venom compared to other patients (p < 0.001). The rate of Grade 3 in the EAACI classification was significantly higher in patients who developed anaphylaxis due to venom compared to other cases (p < 0.001). ConclusionOur study was conducted in a city such as Istanbul, which connects both Asian and European continents. Moreover, it is important because it was conducted in a centre with the highest number of Allergy and Immunology outpatients per year in our country. It is important because it gives the prevalence of anaphylaxis and emphasises the risk factors for each allergen separately.

Heat Supply to Industrial Processes via Molten Salt Solar Concentrators

About one-third of world energy production is destined to the industrial sector, with process heat accounting for about 70% of this demand; almost half of this quota is required by endothermic processes operating at temperatures above 400 °C. Concentrated solar thermal technology, thanks to cost-effective high-temperature thermal energy storage solutions, can respond to the renewable thermal energy needs of the industrial sector, thus supporting the decarbonization of hard-to-abate processes. Particularly, parabolic trough technology using binary molten salts as heat transfer fluid and storage medium, operating up to 550 °C, could potentially supply a large part of the high-temperature process heat required by the industry. In this work, four industrial processes, representative of the Italian industrial context, that are well suited for integration with molten salt concentrators are presented and discussed, conceiving for each considered process a specific coupling solution with the solar plant, sizing the solar field and the thermal storage unit, and computing the cost of the process heat and its variation with the storage capacity. Considering cost data from the literature associated with the pre-COVID-19 era, an LCOH comprising the range 5–10 c€/kWhth was obtained for all the cases studied, while taking into account more updated cost data, the calculated LCOH varies from 7 to 13 c€/kWhth.

Perancangan Sistem Informasi Pengolahan Data Rekam Medis Elektronik Guna Menunjang Tata Kelola Pelaporan Rawat Jalan

Recording and reporting medical records is the main activity in health service institutions, and hospital information systems play an essential role in this process. Outpatient data processing at XYZ Hospital uses spreadsheets and Google Sheets even though it has yet to implement SIMRS fully. Because the data in the SIMRS must be changed for each spreadsheet report, there are several reporting problems. Therefore, the authors begin to develop a web-based outpatient reporting system after researching the need for more efficient applications. This study uses a qualitative approach to data collection through interviews and observations, focusing on developing a waterfall software. The results showed that searching and managing patient data and making outpatient recapitulation reports became easier for medical record officers. Implementing this system brings several concrete impacts, including reducing human errors in data recording, increasing the speed of access to medical information, and increasing time efficiency in making reports. This system also allows better data integration between hospital departments, improving patient care coordination and the overall quality of health services.

Hierarchically structured hollow PVDF nanofibers for flexible piezoelectric sensor

The emergence of flexible sensors addresses the limitations of traditional detection equipment, such as large size, high cost, and inconvenient portability. These sensors have significantly advanced the development of wearable electronic devices for applications in electronic skin, energy harvesting, and energy storage. To enhance the sensitivity of flexible sensors, we developed a hierarchical polyvinylidene fluoride (PVDF) nanofiber-based piezoelectric sensor. By utilizing coaxial electrospinning, we fabricated nanofibers with hollow interiors and porous outer walls. Additionally, microstructures were constructed on the fiber membrane surface by modifying the collector’s shape. The resulting microstructured hollow PVDF nanofiber membrane exhibited high β-phase content (91.31 %), excellent flexibility (maximum strain 56.9 %), and high porosity (88.94 %). The sensor demonstrated a sensitivity of 2.7 V/N (1.08 V/kPa) and a maximum output voltage of 10.1 V, approximately three times higher than that of solid PVDF nanofibers without microstructures. Even after 14,400 cycles of impact, the sensor maintained stable output. The sensor was successfully applied to human activity monitoring and gesture recognition, showcasing its ability to monitor various human activities, respond rapidly (60.4 ms), and synchronously control a mechanical palm to perform different gestures. This work highlights the potential of hierarchically structured hollow PVDF nanofibers in advancing the performance and application scope of flexible piezoelectric sensors.

First principles investigation for the hydrogen storage properties of novel lithium-based XLiH3 (X=K, Rb) perovskite-type hydrides for advance hydrogen storage system

In this work, the density functional theory is used to investigate the structural, mechanical, electronic, dynamic, thermodynamic, optical and hydrogen storage properties of XLiH3 (X = K, Rb) for the first time. Both KLiH3 and RbLiH3 materials exhibit dynamic, mechanical and thermodynamic stability. The lattice parameters of KLiH3 and RbLiH3 are 3.908 and 4.070 Å, respectively. The investigation of Cauchy pressure, Poisson's ratio and B/G ratio shows that KLiH3 and RbLiH3 are brittle materials. Moreover, the electronic properties of XLiH3 hydrides demonstrate that KLiH3 and RbLiH3 show metallic nature. Optical properties of these compounds are studied and reveal that they have very high refractive indexes and dielectric functions. The thermodynamic properties, including heat capacity, entropy, enthalpy, and free energy of XLiH3, are investigated as well. The hydrogen storage capacities of KLiH3 and RbLiH3 are 5.805 and 3.071 wt%, respectively, confirming that KLiH3 has a high hydrogen storage capacity and is more suitable as a hydrogen storage material. Our study opens up a new-pathway for designing novel hydrogen storage materials.

Head in the clouds: A Deleuzoguattarian analysis of the environmental impacts of digital memory

Digital memory in the twenty-first century is a complex combination of human and nonhuman elements that interact in various combinations. In an era where environmental devastation is inundating the planet, it is vital to address the digital’s role in this degradation. This article explores various facets of the environmental implications of the digital storage of memory objects using Deleuze and Guattari’s assemblage theory. I identify the ways in which the digital realm is constructed, or ‘territorialised’ in Deleuzoguattarian terms. Beyond identifying the most common myths related to digital memory’s environmental impact, I expand on the work of information theorists such as Clements, Floridi, and Ess by forwarding three ways in which digital memory practices can be deterritorialised. These approaches include (1) knowledge acquisition, (2) taking response-ability, and (3) anti-redundancy movements. I argue that it is vital for cloud storage users, especially those who self-identify as environmentally conscious, to align their online memory practices with accurate understandings of the environmental impacts of the digital.

Implementasi Sanitasi Data Pada Sistem Operasi Android dengan Metode Gutmann

Data security and privacy are essential for all mobile device users, especially Android. However, deleted data can generally still be recovered using forensic analysis of the storage media hardware with data recovery software. For this reason, you need a data deletion application capable of deleting safely. Many methods are available for safe deletion, such as applying different numbers of passes (overwriting). This research proves that most available methods cannot be deleted entirely and can be recovered, so a data deletion application was created using the most up-to-date method, the Gutmann Method. This method uses 35 number of operands to overwrite the file. Applications are made by analyzing system requirements and implementing them into mobile programming. Then, a comparison test is carried out with other existing applications. The results show that applications created using the Gutmann method are 33% less likely to find file traces than the best comparison application.

Klasifikasi Data Mining Prediksi Penjualan dengan Metode Appriori

Abstract Databases stored on storage media are rarely used by most of their users and even within a certain period of time the data is deleted because it is considered trash and only fills up the storage media. This assumption is not entirely true, because in fact a large database can provide the information needed for various interests, both for business interests in making decisions and for science and research. The development of information and communication technology in this era often called the millennial, information and communication technology is also increasingly advanced and developing and cannot be avoided. Where the development and progress of information and communication technology is growing very rapidly, such as the need for data processing which is increasing every day and if left alone, the data will be useless. By using the Text Mining technique, the classification method, a sentiment will be known to be positive, neutral or negative. One of the algorithms widely used in sentiment analysis is the Naïve Bayes classification method. This study uses the Naïve Bayes Classifier (NBC) method with tf-idf weighting accompanied by the addition of an emotion icon conversion feature (emoticon) to determine the existing sentiment class from tweets about Agu Ate Store. The results of the study show that the Naïve Bayes method without additional features is able to classify sentiment with an accuracy value of 96.44%, while if the tf-idf weighting feature is added along with the emotion icon conversion, the accuracy value can be increased to 98%.

Antimicrobial Resistance and Use on Chinese Dairy Farms: Awareness and Opinions Regarding Selective Treatments of Farm Managers.

In China's expanding dairy industry, a lack of oversight regarding antimicrobial use and increasing antimicrobial resistance are evident. Selective treatments of dairy cows for clinical mastitis or dry cow therapy are proposed to promote judicious antimicrobial use without adversely impacting cattle health. These approaches have been successfully implemented on farms in other countries. On 28 October 2023, a 2-day in-person seminar was held in Beijing, China, on selective antimicrobial treatments of dairy cows for clinical mastitis or dry cow therapy on large Chinese dairy farms. Concurrently, a qualitative study involving 15 technical managers from the 13 largest Chinese dairy groups used focus group discussions and questionnaires to explore perspectives on selective treatments of dairy cows for clinical mastitis or dry cow therapy. The main outcomes assessed were opinions and concerns regarding implementing selective antimicrobial treatments. Although there was diversity of cognition on AMR and selective treatments, the technical managers were generally positive regarding adoption of selective treatments. However, they expressed a need for more evidence and tools, including anticipated economic impacts, effects of delaying treatment until diagnosis, accurate interpretation of milk recording data, safe use of internal teat sealants, and spread of pathogens. Participants stressed the need for awareness, staff training, farm management, and China-specific standards, suggesting large-scale trials to assess efficacy of selective treatments. The findings revealed key challenges and barriers currently impeding selective AMU practices. These insights could inform efforts to promote judicious AMU on farms through targeted treatment regimens, reducing mounting selective pressure driving resistance.

Exploring Porous Media for Compressed Air Energy Storage: Benefits, Challenges, and Technological Insights

The global transition to renewable energy sources such as wind and solar has created a critical need for effective energy storage solutions to manage their intermittency. This review focuses on compressed air energy storage (CAES) in porous media, particularly aquifers, evaluating its benefits, challenges, and technological advancements. Porous media-based CAES (PM-CAES) offers advantages, including lower costs and broader geographical availability compared to traditional methods. This review synthesizes recent advancements in numerical modeling, simulation, and experimental studies, which have enhanced the understanding of air–water–heat flow interactions and improved efficiency in these systems. Field studies demonstrate that using existing idle and abandoned wells can minimize infrastructure costs and environmental impact. This review underscores the potential of CAES in porous media to support the growing demand for sustainable and reliable energy storage solutions.

Rapid hydrogen enclathration and unprecedented tuning phenomenon within superabsorbent polymers

Clathrate hydrate has emerged as a potentially viable storage medium for efficient hydrogen storage, owing to its eco-friendly characteristics and high hydrogen storage capacity. However, it is essential for its practical application to address the challenges posed by harsh thermodynamic formation conditions and slow formation kinetics for hydrogen hydrate. Here, we introduce the utilization of superabsorbent polymers (SAPs) as a dispersion matrix for tetrahydrofuran (THF) solutions to develop a method for rapid hydrogen enclathration. We investigated two distinct synthetic pathways, solution-borne and hydrate-borne routes. We also explored the relationship between hydrogen uptake/storage capacity, varying THF solution concentration within SAPs, and synthetic pathways for binary THF–hydrogen hydrates. The hydrogen storage capacity after 200 min enclathration reaction was relatively low for 1.0 mol% THF cases but significant for 5.56 mol% THF cases in hydrate-borne route (around 20 mmol H2/mol water), highlighting its potential for hydrogen storage material. The spectroscopic analysis revealed that the tuning phenomenon in THF 1.0 mol% hydrate was only observed in the solution-borne route, which facilitated hydrogen enclathration in partially vacant large cages of sII hydrates. It was striking that the tuning phenomenon was also observed in THF 5.56 mol% hydrate synthesized in both solution-borne and hydrate-borne pathways. Through phase equilibria measurements, we confirmed that less than 5.56 mol% of THF participated in forming binary hydrates. The different water and THF absorbability of SAPs resulted in a non-uniform distribution of THF solution within SAPs, causing the unprecedented tuning phenomenon. These findings provide valuable insights into the potential of SAPs for rapid hydrogen enclathration media, emphasizing the importance of understanding synthetic pathways and solution absorption properties for optimized hydrogen storage.

Supplementation of sperm cooling medium with Eurycoma longifolia extract enhances native Thai chicken sperm quality and fertility potential.

Cooled semen storage methods result in oxidative stress generated by an imbalance between oxidation rates, specifically reactive oxygen species production, and sperm cell antioxidants, leading to degradation of semen quality. We aimed to investigate the impact of adding Eurycoma longifolia (EL) extract as an antioxidant supplement in semen storage medium (IGGKPh semen extender) on semen quality and fertility potential. EL extract at concentrations of 5, 10, 15, and 20 mg/mL was assessed for its antioxidant capacity in IGGKPh semen extender. Our findings revealed that the total phenolic content in the EL extract did not vary significantly across the various concentrations and temperatures tested. However, incubation at 5°C was found to be the most effective temperature for increasing the EL extract antioxidant capacity as assessed via the 2,2-diphenyl-1-picrylhydrazyl inhibition assay in a dose-dependent manner. Supplementation of the IGGKPh semen extender with 15 mg/mL EL extract was found to enhance semen quality during cold storage for up to 48 h (p < 0.05), as evidenced by decreased malondialdehyde levels in cooled semen (p < 0.05). However, antioxidant enzyme activities showed no significant differences among the various experimental groups (p > 0.05). The fertility test showed that the 15 mg/mL EL extract group stored for 24 h had a higher percentage than the control group (p < 0.05). However, there was no significant difference in percentage between the two groups at 48 h of storage (p > 0.05). The hatchability showed no significant difference in both 24 and 48-h storage periods (p > 0.05). Our results indicated that supplementing the IGGKPh semen extender with 15 mg/mL EL extract may positively influence semen quality during storage, suggesting potential applications for enhancing semen quality.

Lab2clean: a novel algorithm for automated cleaning of retrospective clinical laboratory results data for secondary uses

BackgroundThe integrity of clinical research and machine learning models in healthcare heavily relies on the quality of underlying clinical laboratory data. However, the preprocessing of this data to ensure its reliability and accuracy remains a significant challenge due to variations in data recording and reporting standards.MethodsWe developed lab2clean, a novel algorithm aimed at automating and standardizing the cleaning of retrospective clinical laboratory results data. lab2clean was implemented as two R functions specifically designed to enhance data conformance and plausibility by standardizing result formats and validating result values. The functionality and performance of the algorithm were evaluated using two extensive electronic medical record (EMR) databases, encompassing various clinical settings.Resultslab2clean effectively reduced the variability of laboratory results and identified potentially erroneous records. Upon deployment, it demonstrated effective and fast standardization and validation of substantial laboratory data records. The evaluation highlighted significant improvements in the conformance and plausibility of lab results, confirming the algorithm’s efficacy in handling large-scale data sets.Conclusionslab2clean addresses the challenge of preprocessing and cleaning clinical laboratory data, a critical step in ensuring high-quality data for research outcomes. It offers a straightforward, efficient tool for researchers, improving the quality of clinical laboratory data, a major portion of healthcare data. Thereby, enhancing the reliability and reproducibility of clinical research outcomes and clinical machine learning models. Future developments aim to broaden its functionality and accessibility, solidifying its vital role in healthcare data management.Graphical

Decoupling of Phase and Amplitude Channels with a Terahertz Metasurface Toward High‐Security Image Hiding

AbstractSteganography technology which conceals a message in a carrier to make it invisible is critical for information security. Conventional optical image steganography using diffractive optical components or spatial light modulators suffers from less encoding channel and bulky volume. The emergence of multifunctional metasurface that can manipulate abundant physical dimensions of optical fields allows the multi‐channel image steganography in a compact volume. Here, the image hiding in a metasurface is demonstrated by modulating the amplitude, phase, and polarization states of terahertz (THz) waves completely. Especially, the phase channel can decouple from the amplitude channel based on a Fresnel‐diffraction‐based algorithm. By directly measuring the phase distribution using the homemade THz focal plane imaging system, the number of transmission channels can expand from N to 2N. As a proof of concept, it is shown that the secret images can encode in the phase channel and subsequently extract by using different keys, such as polarization states, detection distances, and its combinations. Moreover, different hiding strategies with different attacker behaviors are also demonstrated. The decoupling of the phase and amplitude channels with a single metasurface may open an avenue toward innovative optoelectronic devices for optical image steganography, data storage, and terahertz communication.

Characteristics of Circulating Fluidized Bed Combustion (CFBC) Ash as Carbon Dioxide Storage Medium and Development of Construction Materials by Recycling Carbonated Ash.

This study validates the attributes of the mineral carbonation process employing circulating fluidized bed combustion (CFBC) ash, which is generated from thermal power plants, as a medium for carbon storage. Furthermore, an examination was conducted on the properties of construction materials produced through the recycling of carbonated circulating fluidized bed combustion (CFBC) ash. The carbonation characteristics of circulating fluidized bed combustion (CFBC) ash were investigated by analyzing the impact of CO2 flow rate and solid content. Experiments were conducted to investigate the use of it as a concrete admixture by replacing cement at varying percentages ranging from 0% to 20% by weight. The stability and setting time were subsequently measured. To produce foam concrete, specimens were fabricated by substituting 0 to 30 wt% of the cement. Characteristics of the unhardened slurry, such as density, flow, and settlement depth, were measured, while characteristics after hardening, including density, compressive strength, and thermal conductivity, were also assessed. The findings of our research study validated that the carbonation rate of CFBC ash in the slurry exhibited distinct characteristics compared to the reaction in the solid-gas system. Manufactured carbonated circulating fluidized bed combustion (CFBC) ash, when used as a recycled concrete mixture, improved the initial strength of cement mortar by 5 to 12% based on the 7-day strength. In addition, it replaced 25 wt% of cement in the production of foam concrete, showing a density of 0.58 g/cm3, and the 28-day strength was 2.1 MPa, meeting the density standard of 0.6 grade foam concrete.

Developing a BIM based digital twin system for structural health monitoring of civil infrastructure

Abstract The utilization of building information modeling (BIM) within digital technology facilitates the creation of three-dimensional representations for monitoring data in large-scale civil infrastructure. In response to the need for intelligent structural management, this study establishes a structural health monitoring (SHM) system and foundational framework based on digital twins. This framework integrates information from various sources and facilitates collaborative efforts for structural operation and maintenance. Additionally, the SHM system integrates actual monitoring measurements and early warning mechanisms to consolidate multi-source monitoring data with BIM. Through real-time analysis, the system provides insights into the operational status of bridges, capturing geometric, physical, and performance evolution characteristics. To construct the system, engineering challenges are initially digitized, with appropriate sensors deployed on real bridge structures to monitor dynamic (acceleration) and static (strain, displacement) physical information during bridge operation. Subsequently, through wireless communication and data storage technologies, the monitored physical data serves as input for mode identification and early warning algorithms, facilitating the acquisition of structural performance information. Finally, three-dimensional display technology enables real-time calculation and rendering of BIM models, fostering the exchange and interaction of monitoring and BIM information, thus enhancing the intelligence of SHM system.

Introduction to the magnetotellurics special issue of exploration geophysics

The geophysical technique of magnetotellurics (MT) was first described in 1953 and the associated technique of geomagnetic depth sounding (GDS) in 1959. Both methodologies have had a long history in Australia both for academic research and resource exploration. Since the early 1990s with advances in digital data storage, 2D inversion codes and 3D inversion codes from the 2010s, there has been a rapid increase in the number of MT surveys across Australia. Regional MT programs around Australia and since 2013 the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP) have steadily mapped the 3D resistivity of the Australian continent. To complement the regional AusLAMP MT sites numerous additional transects, and broadband MT grids have been deployed providing remarkable new insights into the tectonic evolution of the Australian lithosphere and provide the link to crustal mineral resources. In this special edition, ten papers explore different aspects of MT research in Australia over the last decade.

Exploration of new function for thermal energy storage: Temperature stabilizer

Thermal energy storage (TES) is a technology that stores thermal energy by heating or cooling a storage medium so that the stored energy can be used when needed. TES is usually used in greenhouse heating, centralized solar power, and industrial waste heat recovery to improve the efficiency of energy utilization. This article explores a new application of TES, which relies on its constant outlet temperature to provide stable working conditions for other components. A simulation consisting of 10 cycles with a total length of 100 h is designed. Each cycle contains 5 h of discharge and 5 h of charge, achieved by adjusting the inlet temperature. Rock and NaNO3 are selected as materials for sensible and latent heat storage. This paper discusses the temperature distribution and thermal storage capacity of TES under alternating inlet temperature. The results indicate that the outlet temperature of sensible heat storage will fluctuate and the maximum amplitude is 4.56 K. For latent heat storage, the outlet temperature is constant, and fluid temperature and liquid phase ratio distribution do not change with the number of cycles. There is a significant temperature difference between fluid and solid in phase transition stage, with a maximum value of 10.72 K. Mathematical relationship between latent heat storage parameters and the minimum length of TES is obtained.

Criteria for second generation comparator tests in validation of novel HPV DNA tests for use in cervical cancer screening.

While HC2 and GP5+/6+ PCR-EIA were pivotal in test validation of new HPV assays, they represent the first generation of comparator tests based upon technologies that are not in widespread use anymore. In the current guideline, criteria for second-generation comparator tests are presented that include more detailed resolution of HPV genotypes. Second-generation comparator tests should preferentially target only the 12 genotypes classified as carcinogenic (IARC-group I), and show consistent non-inferior sensitivity for CIN2+ and CIN3+ and specificity for ≤CIN1 compared to one of the first-generations comparators, in at least three validation studies using benchmarks of 0.95 for relative sensitivity and 0.98 for relative specificity. Validation should take into account used storage media and other sample handling procedures. Meta-analyses were conducted to identify the assays that fulfill these stringent criteria. Four tests fulfilled the new criteria: (1) RealTime High-Risk HPV Test (Abbott), (2) Cobas-4800 HPV test (Roche Molecular System), (3) Onclarity HPV Assay (BD Diagnostics), and (4) Anyplex II HPV HR Detection (Seegene), each evaluated in three to six studies. Whereas the four assays target 14 carcinogenic genotypes, the first two identify separately HPV16 and 18, the third assay identifies five types separately and the fourth identifies all the types separately.

Gender, Race, and Ethnicity in Lung Cancer Clinical Trial Participation: Analysis of 253,845 Patients From 2002 – 2021

Lung cancer remains the largest cause of cancer-related death, and multiple large studies have identified persistent racial disparities in lung cancer outcomes. In this study, we utilize public recording of lung cancer data on clinicaltrials.gov to sample age, gender, racial, and ethnic characteristics of participants in lung cancer clinical trials. Clinicaltrials.gov, a US federal government repository of clinical trials was queried for the term "lung cancer" and several other related terms. A list of all studies matching these criteria was generated and information regarding age, gender, ethnicity, and racial breakdown of participants was analyzed. Studies that did not report results to clinicaltrials.gov or had at least one non-US site were excluded. Hypothesis testing was performed with Student's T-test and Chi-squared testing. Trends were analyzed using Spearman testing in Python (VS Code, Microsoft, Redmond, WA 2023) RESULTS: Rates of minority (non-white) and female participation in US lung cancer clinical trials have exhibited a significant increase (p<0.01) over the last 20 years (2002-2021, Figures 1) but still do not represent parity with lung cancer incidence. Subset analysis by offered intervention did not show a significant difference between studies that offered surgical or non-invasive intervention in race, gender, or ethnic participation. NIH-funded studies do not appear to have recruited any Hispanic participants as assessed by reporting on clinicaltrials.gov. The rates of race and ethnicity reporting have also significantly increased over the last 20 years (Figure 1C). Our data demonstrate that there are persistent but improving racial and ethnic disparities in lung cancer clinical trials. Limitations of this study include poor reporting of results on clinicaltrials.gov. These findings demonstrate significant progress in the recruitment of minority participation, but also identify a significant role for policy changes to align participation with lung cancer incidence.