TPS 752: Respiratory effects and allergies, Exhibition Hall, Ground floor, August 27, 2019, 3:00 PM - 4:30 PM Background: Indoor environment factors can influence asthma and allergic disease in preschool children but few studies are available on associations between early life exposure and incidence/remission of children’s disease in their early childhood. Methods: Data on children’s symptoms and home environment factors were collected from questionnaires completed by parents of children from 10 kindergartens in Taiyuan, China. Binary logistic regression models and reduced regression models were used to analyze associations between indoor environment factors and children’s symptoms (wheeze, rhinitis and eczema). Results: Visible mold [OR=1.60(1.24, 2.07)], window pane condensation [OR=1.22(1.02, 1.47)], moldy odor [OR=1.90(1.34, 2.87)], air dryness [OR=1.40(1.15, 1.71)] and stuffy odor [OR=1.53(1.24, 1.88)] were associated with prevalence of rhinitis. Visible mold [OR=1.53(1.12, 2.11)], air dryness [OR=1.42(1.11, 1.83)] and stuffy odor [OR=1.58(1.23, 2.04)] have association with prevalence of wheeze. Stuffy odor [OR=1.39(1.03, 1.88)] and pets [OR=1.73(1.20, 2.49)] have association with eczema in the first 2 years. Comparing the prevalence of children’s symptoms in the first 2 years and last year, visible mold [OR=1.51(1.08,2.91), 1.63(1.22,2.18), 1.92(1.13,3.24)], air dryness [OR=1.78(1.39,2.28), 1.46(1.18,1.81), 2.10(1.37,3.21)] and new furniture or renovation [OR=1.37(1.07,1.75), 1.31(1.07,1.61), 1.65(1.08,2.54)] have positive associations with the onset of children’s wheeze, rhinitis and eczema symptoms from first 2 years to last year of children, respectively. Conclusion: The results showed that exposure to visible mold can be a risk factor for both prevalence and incidence of children’s asthma/allergic symptoms. Indoor air quality (air dryness, moldy odor, stuffy odor and new furniture or renovation) can influence childhood asthma later in life. Early life exposure to mold and dampness should be avoided at home. Chemical emissions during early life from new furniture or renovation can also be a health problem.