Occurrence Of Disease Research Articles

Biological Effects and Clinical Application of the Anti-Immunoglobulin E Antibody

Immunoglobulin E (IgE) plays a crucial role in the occurrence and development of allergic diseases. Since the discovery of IgE in 1967, the pathogenesis of allergic inflammatory diseases has been progressively revealed thereby providing a theoretical foundation for the development of therapeutic anti-IgE antibodies, which have emerged as a new method for the treatment of allergic diseases. In this paper, we aim to summarize and elaborate on the mechanism of biological effects and clinical application of anti-IgE antibodies by examining related global literature, particularly regarding Omalizumab in the past 5 years. We seek to establish theoretical foundations for the formation of new strategies for anti-allergic treatment.

Dilodia sapinea as the pathogen causing trunk canker on Pinus bungeana trees in China

Pinus bungeana belonging to the genus Pinus is a pine tree species endemic to China. It plays vital roles in afforestation, forest regeneration, landscaping, forest ecosystems, and environmental protection. However, P. bungeana has been listed as a rare and endangered species in recent years due to population fragmentation. The occurrence of lethal diseases on the trees has made the situation even worse. This study aimed to identify the pathogen causing the trunk canker on P. bungeana trees in Qingdao, China. The morphological identification of the pathogen relied primarily on the morphology of conidia. Molecular identification was performed using the combined sequences of ITS, Tef and Tub2 genes. The eight isolates were all identified as Diplodia sapinea. The pathogenicity of the eight isolates was examined both in vitro and in vivo. The results showed that all the fungal isolates caused severe canker symptoms on the inoculated P. bungeana branches. Moreover, D. sapinea was re-isolated from the inoculated branches. This study is novel in reporting D. sapinea causing trunk canker on P. bungeana trees in China.

Disease assessment in 'coral gardening' nurseries in the Maldives and implications for coral restoration success.

Coral diseases are an increasing threat to continuously degrading reefs as disease abundance and virulence are expected to increase in the future. Active conservation measures, specifically coral restoration projects, are increasingly being implemented worldwide. Yet little is known about the implications of disease occurrence in a restoration context. This study describes white syndrome pathogenesis in 2 coral genera, farmed in 2 mid-water rope nurseries located in a reef and a lagoon habitat in the Maldives. Over a 112 d monitoring period, disease metrics were obtained from 336 Pocillopora and 96 Acropora fragments to assess the impacts of unmitigated disease progression in coral nurseries. Disease had low prevalence (2.2%) and incidence (0.007) in reef-farmed Pocillopora, but survival (91%) was significantly reduced in comparison with the unaffected lagoon-farmed Pocillopora (99%). In contrast, lagoon-farmed Acropora showed high disease prevalence (78.5%) and incidence (0.064), and a lower survival (79%) than disease-unaffected reef-farmed Acropora (98%). These findings had distinct implications for coral gardening success. While Pocillopora was considered suitable for outplanting, especially since subsequent mitigation interventions were successful, the diseased, lagoon-reared Acropora posed a potential risk to the restoration site and was unsuitable for outplanting following 1 yr of farming effort. Our findings demonstrate that unmitigated diseases can cause major setbacks to restoration success. Coral gardening projects are likely to be particularly susceptible; therefore, disease monitoring and risk management are imperative. Since there is currently a lack of available diagnostic and mitigative tools, this study aims to provide case study data for restoration practitioners.

The Influence of Regional Specialization in Agriculture on Farmers’ Pest Control Behaviors Based on a Dual Examination of Control Strategies and Control Costs

The pest control behaviors of agricultural producers are crucial not only for effectively managing pests and diseases but also for ensuring the sustainable development of agricultural production and the environment. Regional specialization in agriculture, as a typical method to optimize planting structure, influences farmers’ control behaviors through dual mechanisms. However, existing research has largely overlooked this issue. This paper systematically examines the influence and mechanisms of agricultural regional specialization on farmers’ pest control strategies and costs. Using village tracking research data and farmer data from the Jiangsu, Sichuan, and Jilin provinces of China over 15 years, the study employs fixed-effects models and the instrumental variable method to provide empirical evidence. The research results indicate that by reducing biological diversity, which exacerbates the occurrence and damage of pests and diseases, and increasing the homogeneity of cropping structures, the development of regional specialization in agriculture prompts farmers to shift their control strategy from “ex post treatment” to “ex ante prevention” and has increased the control costs. The policy implication is that farmers should be encouraged to practice moderate crop rotation in rapidly increasing regional specialization. Additionally, strengthening real-time monitoring of pest and disease dynamics is essential to guide farmers in early prevention and timely control.

Pediatric masks of obstructive sleep apnea syndrome

A number of factors contribute to the occurrence of chronic otolaryngological diseases in children at an early age, which often acquire a long, undulating course with exacerbations, relapses and complications. The increasing aggressiveness of environmental factors, the growth of allergization of the population, the formation of strains of microorganisms resistant to the action of medicines, lead to a steady increase in diseases of the nasopharyngeal tonsils and a worsening of their course, especially among children, both in our country and abroad. At the same time, the adenotonsillar problem has long gone beyond ENT pathology and attracts the attention of a wide range of medical resea. The aim of the work: to analyze the literature data on clinical manifestations, laboratory and instrumental diagnostic methods and the prevalence of OSA in children. The analysis of publications using PubMed, EMBASE and Web of Science search engines in the period from January 1970 to March 2024 related to research on epidemiological, pathogenetic, clinical and laboratory aspects of OSA in children and adults was carried out. rchers. Sleep respiratory disorder is a term covering various clinical diagnoses from primary snoring to obstructive sleep apnea. This clinical symptom is registered in at least one in nine children, which makes it one of the most frequently diagnosed sleep disorders and puts it in the category of serious social problems. The most compelling evidence relates to hyperactivity, inattention, and social problems: decreased social competence, increased problematic behavior, and decreased memory scores. Despite the growing body of evidence suggesting cognitive impairment in children with snoring, many results have been contradictory. The availability of pediatric sleep laboratories, even in countries with advanced health systems, is limited, which encourages the search for less complex and more convenient testing methods. Timely detection of the development of the disease allows you to prevent complications and improve the quality of life. The article also describes clinical cases of late diagnosis of obstructive sleep apnea in children.

Characteristics of soil microbial community assembly patterns in fields with serious occurrence of tobacco Fusarium wilt disease

IntroductionFusarium wilt disease (FWD) of tobacco is a destructive disease caused by Fusarium spp. in tobacco-growing regions worldwide. The Fusarium spp. infection may alter the composition and structure of the tobacco root microbial community; however, the relationship between these factors under large-scale geographical conditions in China remains underexplored.MethodsIn the context of this investigation, soil samples from the rhizosphere of tobacco plants were procured from fields afflicted with FWD and those devoid of the disease in the Hanzhong region of Shaanxi province, as well as in the Sanmenxia and Nanyang regions of Henan province. These regions are recognized for the commercial cultivation of tobacco. The examination focused on discerning the influence of tobacco FWD on the composition and configuration of the rhizosphere microbial community, along with their co-occurrence patterns. This scrutiny was underpinned by targeted PCR amplification and high-throughput sequencing (amplicon sequencing) of the 16S rRNA gene and the ITS1 region.ResultsThe amplicon data analyses showed that FWD influenced the microbial structure and composition of the tobacco rhizosphere soil. FWD had a greater impact on the microbiome of the tobacco fungal community than on the microbiome of the bacterial community. Healthy plants had the ability to recruit potential beneficial bacteria. Diseased plants were more susceptible to colonization by other pathogenic fungi, but they still had the capacity to recruit potential beneficial bacteria. The analysis of microbial intra- and inter-kingdom networks further indicated that FWD destabilized microbial networks. In the overall microbial interaction, microorganisms primarily interacted within their boundaries, but FWD increased the proportion of interactions occurring across boundaries. In addition, FWD could disrupt the interactions within microbial network modules.DiscussionThis study provides evidence that FWD can cause changes in the composition and network of microbial communities, affecting the interactions among various microorganisms, including bacteria and fungi. These findings contribute to our understanding of how plant microbiomes change due to disease. Furthermore, they add to our knowledge of the mechanisms that govern the assembly and interactions of microbial communities under the influence of FWD.

The nonlineard association between triglyceride to HDL cholesterol ratio and long-term heart disease risk: findings from China Health and Retirement Longitudinal Study (CHARLS).

The aim of this study was to investigate the relationship between triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) and the risk of cardiovascular disease (CVD) in middle-aged and elderly Chinese population. CVD has high morbidity and mortality in China, with 5.09million CVD deaths in 2019 and a mortality rate of 364.5 cases per 100,000 people. Existing studies have focused on specific populations and lack studies on the general population. This study used data from the China Health and Aged Care Tracking Survey (CHARLS) to analyse the middle-aged and elderly population between 2011 and 2020. The exposure variable was TG/HDL-C ratio, the outcome variable was the occurrence of heart disease (including myocardial infarction, coronary heart disease, etc.), and the covariates included age, gender, education level, and body mass index. The final sample size was 4,551 participants. Weighted Cox regression models were used to assess the association between TG/HDL-C and CVD risk, and nonlinear associations and stratified analyses were performed. The results demonstrated a significant association between TG/HDL-C ratios and cardiac morbidity, with a risk ratio of 0.71 (95% CI: 0.71-0.71) in the adjusted model II. Nonlinear analysis revealed a threshold effect. Within the TG/HDL-C 0.15-1.5 interval (inflection point LnTG/HDL-C 0.41), each 1-unit increase in Ln (TG/HDL-C) was associated with a 17% reduction in the risk. The inflection point was associated with a 0.83-fold reduction in the risk of CVD (95% CI: 0.75, 0.92; p = 0.0003), but beyond this point, the association was no longer significant (1.00-fold reduction in risk; 95% CI: 0.95, 1.05; p = 0.9701). In contrast, stratified analyses demonstrated that the results were more applicable to women and those younger than 65 years. In summary, the study found a significant inverse relationship between the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the risk of cardiovascular disease in the middle-aged and elderly Chinese population, with a nonlinear threshold effect observed at a TG/HDL-C ratio of around 1.5.

Acquired and genetic determinants of disease phenotype and therapeutic strategies in C3 glomerulopathy and immunoglobulin-associated MPGN.

C3 glomerulopathy (C3G), a prototype of complement mediated disease, is characterized by significant heterogeneity, not only in terms of clinical, histological and biological presentation but also of prognosis, and response to existing therapies. Recent advancements in understanding the factors responsible for alternative pathway dysregulation in the disease have highlighted its even more complex nature. Here, we propose a reexamination of the diversity of C3G presentations in light of the drivers of complement activation. Autoantibodies targeting complement proteins, genetic abnormalities in complement genes and monoclonal immunoglobulins are now well-known to drive disease occurrence. This review discusses how these drivers contribute to the heterogeneity in disease phenotype and outcomes, providing insights into tailored diagnostic and therapeutic approaches. In recent years, a broad spectrum of complement inhibitory therapies has emerged, soon to be available in clinical practice. The recognition of specific clinical, biological, and histological patterns associated with different forms of C3G is crucial for personalized management, particularly treatment strategies.

The evaluation of the effectiveness of bacterial lysate in preoperative preparation of children with adenotonsillar pathology

In childhood, the occurrence and steady growth of diseases of the nasopharyngeal tonsils, often acquiring a chronic course and occurring with exacerbations and complications, is facilitated by a number of factors. Etiological factors of adenotonsillar diseases in children are both bacterial and viral pathogens, among which respiratory viruses are among the most significant. Herpes virus infections (HVI) play an important role in the development of chronic upper respiratory tract pathology, especially in the cohort of frequently ill children. Representatives of the herpes virus family are characterized by lymphotropic action, long-term persistence in the body, and a tendency to reproduce in cells, leading to a violation of the immune status. The incidence of relapses in the postoperative period during surgical interventions in the ENT organs in children remains high. Herpesvirus etiology of recurrent infectious and inflammatory diseases of the URT (upper respiratory tract) is the leading factor in the ineffectiveness of tonsillotomy, adenotomy, and repeated proliferation of lymphoid tissue in the postoperative period in preschool children. The use of a drug from the group of bacterial lysates before surgery is justified in the treatment of frequently and long-term ill children with adenotonsillar hypertrophy.

Abstract 4140139: Cardio-ankle vascular index (CAVI) in prediction of chronic coronary artery disease: risk, coronary artery lesions, and cardiovascular disease events

Introduction: The cardio-ankle vascular index (CAVI) is a significant metric for evaluating arterial function. The test measures the stiffness of the arteries from the beginning of the aorta to the ankle, and the algorithm used is not influenced by blood pressure. Recent statistics indicate that a high CAVI score has the potential to predict future cardiovascular disease (CVD) occurrences. However, no research has been conducted in Vietnam to investigate this matter. Methods: A prospective study was conducted on 222 patients. Out of these, 162 patients had chronic coronary artery disease (CAD), while the remaining 62 patients were free of CAD. The study took place between October 2019 and December 2022. Participants who fulfilled the criteria were evaluated using the CAVI baseline measurement and clinical and paraclinical parameters. A total of 162 patients with chronic coronary artery disease (CAD) were monitored for cardiovascular disease (CVD) events over a period of 2 years. Results: CAVI in chronic CAD patients (9.21±0.79) was significantly higher compared to those in free-CAD patients (8.48 ± 0.62) with p<0.001. CAVI with a cut-off point ≥ 8.83 was a significant predictor for chronic CAD (OR = 9.6; 95%CI: 4.0-18.8). The Area under the curve (AUC) of CAVI for chronic CAD was 0.796 (95% CI: 0.736-0.856 ; p<0.001). In addition, CAVI has a statistically significant increase in severe stenosis (≥75%) and multivessel coronary artery disease. CAVI in the CVD events group (9.77±1.06) was significantly higher than CAVI in the free–CVD events group (9.13±0.72) group (p=0.009). The patients with CAVI ≥9.63 have significantly higher CVD events (HR=6.4 ; 95% CI: 1.9-21.9, p=0.046). Conclusion: CAVI is higher in chronic CAD and can predict chronic CAD with a cut-off point ≥ 8.83. In chronic CAD, CAVI is higher in severe stenosis and multivessel coronary artery disease. Increased CAVI was significantly associated with CVD events.

El Niño southern oscillation, weather patterns, and bacillary dysentery in the Yangtze River Basin, China.

Increasingly intense weather anomalies associated with interannual climate variability patterns, like El Niño-southern oscillation (ENSO), could exacerbate the occurrence and transmission of infectious diseases. However,research in China remains limited in understanding the impacts and intermediate weather changes of ENSO on bacillary dysentery (BD). This study aimed to reveal the relationship between ENSO, weather conditions, and theincidence of BD, and to identify the potential meteorological pathways moderated by ENSO inthe ENSO-BD connections. BD disease data and meteorological data, as well as ENSO index, from 2005 to 2020 were obtained for 95 cities in the Yangtze River Basin. We first established the associations between ENSO events and BD, ENSO and weather, as well as weather and BDs using two-stage statistical models. Then, we applied a causal mediation analysis to identify the specific meteorological changes in the ENSO-BD relationship. In the Yangtze River Basin, both El Niño (IRR: 1.06, 95%CI: 1.04 ~ 1.08) and La Niña (IRR: 1.03, 95%CI: 1.02 ~ 1.05) events were found to increase the risk of BD. Variations of ENSO index were associated with changes in local weather conditions. Both the increases in regional temperatures and rainfall were associated with a higher risk of BD. In the casual mediation analyses, we identified that higher temperatures and excessive rainfall associated with La Niña and El Niño events mediatedthe ENSO's effect on BD, with mediation proportions of 38.58% and 34.97%, respectively. Long-term climate variability, like ENSO, can affect regional weather conditions and lead to an increased risk of BD. We identified the mediating weather patterns in the relationship between ENSO and BD, which could improve targeted health interventions and establish an advanced early warning system in response to the BD epidemic.

Evaluate the effect of exercise core strength training on antioxidant enzyme activity in women from a biomechanical perspective

At present, the incidence rate of chronic diseases is increasing year by year. A variety of antioxidant enzymes in the human body, such as Superoxide Dismutase (SOD), Nitric Oxide Synthase (NOS), Glutathione Peroxidase (GSH Px), Malonic Dialdehyde (MDA) and Catalase (CAT), help to inhibit the generation of oxygen free radicals and play a certain role in preventing the occurrence of chronic diseases. The research on the activity of antioxidant enzymes and the delivery of antioxidant drugs has gradually become the focus of relevant scholars. The physical quality of women is lower than that of men, so it is of great practical significance to study the antioxidant enzyme activity of women. Therefore, this paper explores the influence of exercise core strength training on women’s antioxidant enzyme activity from a biomechanical perspective and concludes that core strength training can improve female students’ SOD content level by 2.58%, and can improve female students’ NOS content level, GSH-Px content level, and MDA content level. Sports core strength training has a positive impact on women’s antioxidant enzyme activity.

Understanding the Pathogenesis, Biocontrol Mechanisms, and Factors Influencing Biocontrol Effectiveness for Soil-Borne Diseases in Panax Plants

Panax plants are known for their significant medicinal and economic value. Being perennial, they are prone to soil-borne diseases during cultivation. However, there has been limited research on the pathogenesis of soil-borne diseases and the diversity of pathogens. While biological control has gained attention for its efficacy and environmental benefits, the factors affecting its efficiency still need thorough evaluation. This review summarizes the influence of biotic factors, such as pathogens and hosts, and environmental factors on the occurrence of soil-borne diseases and pathogen diversity. Additionally, we synthesized bacterial, actinobacterial, and fungal diversity for the biocontrol of soil-borne diseases and their functional mechanisms. Moreover, the review delves into the factors influencing the efficacy of biocontrol, including microbial species, the inoculation method and inoculation volume, and inoculant composition. This article serves as a valuable resource for enhancing the efficiency of biological control and optimizing strategies for managing soil-borne diseases in Panax cultivation in the future.

Research progress on epigenetic mechanism of reproductive disorders

The "Developmental Origins of Health and Disease, DOHaD" theory suggests that adverse factors in early life can lead to the occurrence of chronic diseases in adulthood. In recent years, it has been discovered that maternal factors, intrauterine development environment and environmental exposure during pregnancy can mediate the changes of early egg/embryo development, promote the occurrence of reproductive disorders such as polycystic ovary syndrome, diminished ovarian reserve, and endometriosis, and induce intergenerational genetic effects. This article has reviewed the progress of research on maternal factors which may affect the pathogenesis of reproductive disorders, and expounds its mechanism from the perspectives of epigenetic mechanisms such as DNA methylation, histone modification and non-coding small RNA (miRNA) modification, with an aim to provide insights for studying the occurrence of adult reproductive disorders in early life and before pregnancy.

The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study

BackgroundWe explored if the administration of fluoxetine, recognized for its potential in adipocyte browning, entails a differential risk of coronary heart disease (CHD) in comparison to other SSRI medications.MethodsUsing the National Health Insurance Research Database of Taiwan from 2000 to 2013, we conducted a retrospective cohort study. The exposure cohort comprised individuals prescribed fluoxetine for over 90 days (n = 2,228). Conversely, those administered other SSRIs (excluding fluoxetine) for a duration surpassing 90 days were designated as the non-exposed cohort (n = 8,912). CHD incidence served as our primary outcome measure, and we employed Cox proportional hazards models to scrutinize the relationship between fluoxetine exposure and CHD development rates.ResultsCompared with the non-exposed cohort, the fluoxetine use had a significantly decreased 21% risk of developing CHD in the exposed cohort (adjusted hazard ratio: 0.79%, 95% confidence interval: 0.68–0.92). Noticeably, results indicated that there was an inverse association between the fluoxetine exposure and the risk of CHD, regardless of whether men, women or other age groups.ConclusionOur findings suggest that clinical use of fluoxetine was associated with a 21% reduced risk of CHD relative to other SSRI prescriptions.

Soil fungal networks exhibit sparser interactions than bacterial networks in diseased banana plantations.

Soil microorganisms are pivotal in mitigating soil-borne diseases. The intricate mechanisms underlying the interactions among microbes and their impact on disease occurrence remain enigmatic. This study underscores that a reduction in fungal network interactions correlates with the incidence of soil-borne Fusarium wilt.

Postoperative air in the cisterns or ventricles predicts early leptomeningeal disease of brain metastases: a retrospective study

We investigated whether air in the cisterns or ventricles on postoperative computed tomography (reflecting the opening of the cerebrospinal fluid spaces during surgery) is a predictor of classical or nodular leptomeningeal disease after resection of brain metastases. We retrospectively analyzed 73 patients who underwent gross total resection of brain metastases between 2012 and 2020. Patients with air in the cisterns or ventricles on postoperative day 1 computed tomography were categorized into the air-positive group, whereas those without air in the cisterns or ventricles on postoperative day 1 computed tomography were categorized into the air-negative group. The primary outcome was the occurrence of classical or nodular leptomeningeal disease, which was assessed using survival analysis. There were 15 (21%) patients in the air-positive group and 58 (79%) in the air-negative group. The air-positive group exhibited significantly more cerebellar and ventricular contact lesions than the air-negative group. The 4-year rate of classical or nodular leptomeningeal disease was significantly higher in the air-positive group than in the air-negative group (67% vs. 33%, P < 0.001). Multivariate analysis identified air in the cisterns or ventricles on postoperative computed tomography as the only significant predictor of classical or nodular leptomeningeal disease (P < 0.001). Postoperative air in the cisterns or ventricles can predict early classical or nodular leptomeningeal disease.

Ferroptosis as a Therapeutic Target in Neurodegenerative Diseases: Exploring the Mechanisms and Potential of Treating Alzheimer's Disease and Parkinson's Disease.

Amidst the rising global burden of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, there is an urgent need for novel therapeutic strategies to combat these debilitating conditions. These diseases are characterized by progressive neural dysfunction leading to cognitive impairments, for which current therapeutic strategies remain palliative at best. Recently, the discovery of ferroptosis, a novel cell death mode that is different from apoptosis and autophagy, has opened new avenues in the field of cognitive research. With in-depth research on ferroptosis, the clinical significance of iron homeostasis disorders and lipid peroxidation in the occurrence, development, and treatment of neurodegenerative diseases are gradually becoming apparent. This study aims to elucidate the roles of ferroptosis in the context of neurodegeneration and to explore its potential as a therapeutic target. By unraveling the intricate relationship between iron homeostasis disorders, oxidative damage, and lipid metabolism disturbances in these diseases, new intervention targets are revealed. It offers a new dimension to the management of neurocognitive impairments in Alzheimer's and Parkinson's diseases. The implications of these findings extend beyond just Alzheimer's and Parkinson's diseases. They also have relevance with other neurological conditions characterized by oxidative stress and iron dysregulation. This review contributes to increased knowledge of ferroptosis and provides a foundational understanding that could lead to the development of innovative therapeutic strategies. Ultimately, it may alleviate the development of neurodegenerative diseases and improve cognitive function by preventing ferroptosis, which has not only academic significance but also potential clinical significance.

Epidemiology of Sexually Transmitted and Dermatological Diseases among Patients in 250 Bedded General Hospital, Jamalpur, Bangladesh

Background: Skin diseases are widespread in developing nations. It is commonly acknowledged that the occurrence and characteristics of skin and venereal diseases vary across countries and even within different regions of a single country. These variations are influenced by a complex interplay of social, economic, racial, and environmental factors. Objective: To assess the epidemiology of sexually transmitted infections and skin illnesses among patients visiting the outpatient department of a tertiary care hospital in Bangladesh. Methods: This study was conducted at the outpatient department of skin and venereal diseases at the 250-bedded General Hospital in Jamalpur. The study took place from January 2023 to June 2023 and used a descriptive cross-sectional design. A total of 150 patients, spanning all age groups and presenting with various skin and venereal diseases, were included as the study sample from the 250-bedded General Hospital in Jamalpur during the study period. Data collection was conducted using the purposive sampling method. Results: The study findings revealed that a significant proportion of the patients (28%) fell within the age range of 20-29 years, with 23.3% and 18.7% falling within the age ranges of 10-19 years and &lt;10 years, respectively. A mere 7.3% of individuals were encompassed within the age bracket of 50 years and older. Out of the 150 patients, a majority (54.70%) were male. In the study it was discovered that a noteworthy 14% of the patients were affected by venereal diseases and 86% of the patients were affected by skin diseases. It was particularly noteworthy that the highest prevalence of these venereal diseases was concentrated within the 20-29 years age range, affecting approximately 14.29% of individuals within this group. Specifically, 19.51% of males in the study were found to have venereal diseases, in contrast to a lower prevalence of 7.35% among females. Non-Gonococcal Urethritis (NGU) was a notable condition observed ...

APPROACHES ON SANITATION AND HEALTH IN THE LEGAL AMAZON

The objective of this article is to understand and analyze the approaches employed in study of the relationship between sanitation and health in the Legal Amazon from 2013 to 2023. This article conducts an integrative review of the literature drawing upon the works available in the Scientific Electronic Library Online, Virtual Health Library, and Capes Periodicals. 64 out of 185 studies are analyzed, in line with the research question and after applying the eligibility criteria. The studies are clustered into four thematic categories: (i) occurrence of diseases and injuries; (ii) environmental analysis, which includes studies on the risks of elements present in the soil, water and animals; (iii) technology assessment and proposal of methodologies; and (iv) impact of capitalist expansion. More than half of the studies (56%) refer to the more classic approach, which establishes a relationship between sanitation conditions and the occurrence of diseases and injuries. At the same time, an expansion of theoretical-conceptual approaches to the topic was identified, including a focus on human rights and environmental justice, especially in studies about the impact of capitalist expansion. The results of this research point to the need of improving the critical reflection on the political, economic, and sociocultural determinants inherent to the connections between sanitation and health in Brazil.