Letters1 April 1996Preemptive Ganciclovir Therapy in Renal TransplantationMichael Tamm, MD, Gieri Cathomas, MD, and Gilbert Thiel, MDMichael Tamm, MDUniversity Hospital; Basel, SwitzerlandSearch for more papers by this author, Gieri Cathomas, MDUniversity Hospital; Basel, SwitzerlandSearch for more papers by this author, and Gilbert Thiel, MDUniversity Hospital; Basel, SwitzerlandSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-7-199604010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In a recently published article on low-dose ganciclovir prophylaxis. Hibberd and colleagues [1] found a markedly reduced incidence of CMV disease in renal transplant recipients receiving antilymphocyte globulin. When antilymphocyte globulin was given to treat acute rejection, the incidence of CMV disease was as high as 64% in the 11 placebo recipients. Daily administration of ganciclovir (2.5 mg/kg of body weight) reduced the incidence of CMV disease to 22% (5 of 23 patients). At our institution, eight patients seropositive for CMV were treated with antilymphocyte globulin for steroid-resistant rejection and received higher doses of ganciclovir three times ...REFERENCE1. Hibberd PL, Tolkoff-Rubin NE, Conti D, Stuart F, Thistlethwaite JR, Neylon JF, et al. Preemptive ganciclovir therapy to prevent cytomegalovirus disease in cytomegalovirus antibody-positive renal transplant recipients. A randomized, controlled trial. Ann Intern Med. 1995; 123:18-26. Google Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital; Basel, Switzerland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCounterpoint: Prevention of Cytomegalovirus (CMV) Infection and CMV Disease in Recipients of Solid Organ Transplants: The Case for Prophylaxis 1 April 1996Volume 124, Issue 7Page: 693KeywordsAntigensBody weightCreatinineCytomegalovirus infectionGlobulinsLiverOutpatient clinicsProphylaxisRenal diseasesRenal transplantation Issue Published: 1 April 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...