This paper presents the parametric optimization of single-story steel buildings subjected to high loads. In the parametric study, high loads of snow and wind are determined for different altitudes up to 3000 meters above sea level. The Alpine region and the Eurocode 1 standard are considered. The discrete mixed-integer non-linear programming optimization is performed for different altitude alternatives. The optimization model for the steel structure is developed and used. The mass objective function of the structure is subjected to dimensioning and deflection constraints defined by the Eurocode standards. The modified outer-approximation and equality-relaxation algorithm is applied. The optimal results obtained include the minimal possible mass of the structure, the optimal topology, the steel sections and the steel grade. In the case of a medium-sized single-story steel building, it was found that the structural mass increases by 2.7 times and the number of main portal frames increases by 80 % when the altitude of the building site is increased from 500 to 3000 meters above sea level. The optimal results clearly show how the structural mass and cross-sections increase with increasing load.