Limestone-gypsum wet flue gas desulfurization (WFGD) often produces a certain amount of wastewater with complex water quality and heavy metal pollution which should be treated properly before release. Spaying the desulfurization wastewater into flue duct and using exhausted flue gas heat for evaporation is a promising and economical technology for achieving zero wastewater discharge in thermal power plant. To enable a more in-depth understanding on evaporation of FGD wastewater spray, a visual wind tunnel test rig based on the atomized droplet laser measuring system was built to reveal the impact factors on droplet thermal-fluid behavior. The dominant impact factors such as compressed air pressure and flow rate in air-blast spray nozzle, hot air temperature and velocity in the evaporation tunnel were analyzed to discuss the droplet size distribution and evaporation performance through alternating operate condition. A discrete mathematical model that combines both Eulerian and Lagrangian framework was established to validate the experiment result. It is concluded that introducing high pressure compressed air into the nozzle can contribute to the dispersion of droplets and enhance the evaporation rate. Proper flow rate in spray nozzle is required to avoid incomplete droplets evaporation. Air temperature and velocity in the evaporation tunnel apply positive impact on droplet size distribution and evaporation performance. Numerical simulation results of both dominant factors impact on evaporation behavior and total evaporation rate showed consistency with the experimental outcome.