The rapid re-planning of cities in developing countries has mostly manifested as taking European success of urban approach into society and economy. Many issues in the Eastern areas show that the cities are growing globally under common strategy. This is a case where there is no consideration of the local factors of people mentality, climate, local architectural originality, heritage etc. Human civilization in general is progressively driven by product industry and social behaviors dominate in the world ecosystem, which is specifically circulates in all biological systems and other existing substance. Nonetheless, natural life surviving and high value of utilization by peoples lead to the approach of actual changes among issues. Regionalism begins to rise in the political agenda mostly in European countries (for instance the UK, France, Spain, Germany etc.) leading to growing experiments with both philosophy devolution and environmental degradation. Meantime this process has been getting more academic interest in the way in which regionalism has been inserted into state reconstruction. Nevertheless, all main regional institutions in the civil world actually are changed with pursuing sustainable development as part of their strategic approach to economy, regions planning and urban management. Regionics intends to reveal the significance of these factors of the formation of distinctive and identical architecture, for the creation of the expressive urban space and give a way to the planning of a sustainable city. This paper explores the overall view of the conception of regionics as a new discipline of region and urban planning. Linked to such concept of equal coexisting of human beings and planetary environment has emphasis on planning of livable cities as an integrated concept and indeed integrated device, with its insistence on the needs to see economic, social and environmental issues as always inter-related. Ideas regarding regionalism and sustainable urban planning are applicable in many societies around the world, both in economically developed countries and in regions that have either a chronology of the colonial intervention or the status of developing countries. The monography ‘Regionics’ is the first generalizing, conceptual work on the region and the sustainable development of cities, which has the opportunity for the first time to be presented to a wide audience. This paper also addresses establishing the important requirement of the way of the sustainable strategy for livable cities.