The purpose of this experiment is to know the influence of a single guide vane position and angle to the performance of a cross-flow wind turbine. The cross-flow wind turbine was positioned at the discharge outlet of a cooling tower model to harness the discharged wind for electricity generation. A guide vane was used to enhance the rotational speed of the turbines for power augmentation. Various position and angle of attack of the guide vane were tested in this experiment. To avoid negative impact on the performance of the cooling tower fan and to optimize the wind turbine performance, the turbine position on the discharge wind stream was also studied. The result showed that cross-flow wind turbine with a guide vane attached at the right position had a higher coefficient of power than cross flow turbine without guide vane. A crossflow wind turbine with the guide vane at the position of 150 mm from the center and 30° angles had the highest coefficient of power of 0.49. Comparing to the wind turbine without guide vane, the coefficient of power of the cross-flow wind turbine was increased about 84.3%.