Background: Stroke is the fifth leading cause of death in the US and can result in major disability. It is important to identify factors that increase risk of stroke so that they may be targeted for modification, if possible. Depression can increase risk of stroke, increase risk of death from stroke, and it is related to worse post-stroke outcomes. There is a dearth of research in the Hispanic population, who have a higher burden of disease than non-Hispanic whites and blacks. The goal of this research project was to determine how ethnicity and prior depression affect patient outcomes after first-time stroke. Methods: The study was an analysis of 500 cases from Baptist Hospital of Miami’s Get With The Guidelines-Stroke database (9/2014-5/2015). It was a 2 (Hispanic vs. non-Hispanic) x 2 (prior depression vs. no prior depression) factorial cross-sectional design. Descriptive statistics characterized subjects on baseline characteristics, hospital course, discharge functional status, and discharge disposition. Baseline characteristics included demographics, comorbidities, and NIHSS score. Hospital treatment included whether patients received IV t-PA or neuro-intervention and their turnaround times. Patient outcomes included length of stay (LOS), discharge modified Rankin Scale (mRS), and discharge disposition. Effects of Hispanic ethnicity and prior depression on patient outcomes were analyzed using a nonparametric median test for LOS and chi square analysis for mRS score and disposition. Results: Out of 500 cases that were analyzed, 199 were excluded because of: prior stroke, TIA, MI, or atrial fibrillation, or LOS ≥ 30 days. Of the remaining 301 cases, 195 patients were Hispanic (65%), and 30 were characterized as having depression (9/97 non-Hispanic, 9% and 21/195 Hispanic, 12%). A marginally significant interaction (p=0.061) between ethnicity and depression was found, such that non-Hispanic patients with depression had a shorter LOS than the other three groups (3.7 d vs. 6.3-6.9 d). Of the 301 patients, 171 (57%) were discharged home. Hispanic patients were less likely to be discharged home (54%) compared to 62% of non-Hispanic patients, regardless of depression. Out of 279 patients that had a discharge mRS score, 98 (35%) had a good clinical outcome (mRS 0-2). Only 1/4 of Hispanic patients with depression had a good clinical outcome, vs. 1/3 of patients in the other groups. However, neither ethnicity nor depression had a statistically significant effect on discharge disposition or discharge mRS. Conclusions: There was a combined effect of ethnicity and depression on LOS where non-Hispanic patients with depression had a shorter LOS than other groups. Although not statistically significant, the findings may be clinically important. It is critical to determine whether these patients had less severe strokes or fewer comorbidities, or if patients were discharged too quickly.