Open knowledge has the potential to expand inclusive and equitable access to lifelong learning while supporting social inclusion. However, there is low public awareness on issues around inclusiveness, especially for students with visual disabilities who are unable to use the medium of the sighted owing to the consequences of their disabilities. This article discusses various issues around the accessibility of open educational resources (OERs) and the integration of inclusive institutional culture in the Nigerian university system. An interpretive approach was adopted for this study. Out of 22 universities offering enrolment to students with visual disabilities in Nigeria, seven universities were purposively selected based on the availability of OERs on their websites. The purposive sampling method was also used to choose 30 participants from four out of the seven universities who could serve as key informants for the study. Data were collected using in-depth interviews. Data from interviews was designed to achieve qualitative analyses and results were analysed thematically. The study revealed strategies university libraries could deploy to improve access to OERs for students with visual disabilities and provided insightful thoughts and direction on re-imagining the future of the open knowledge movement in Nigeria and the rest of Africa.