In this note, the concept of a nonlocal biharmonic operator is introduced. When introducing this operator, mappings of the type of involution are used. Namely, in the differential expression of this operator, in addition to the variables 12( , ,..., )nxx xx, transformed arguments with mappings of the form 111,...,,,,...,,1jjjjjnS xxxpx xxj n and their multiplication also involved. Spectral problems with Dirichlet and Neumann-type boundary conditions are considered in an n-dimensional parallelepiped for a given nonlocal biharmonic operator. The eigenfunctions and eigenvalues of the problems under consideration are explicitly constructed. When constructing these elements, eigenfunctions and eigenvalues of the classical biharmonic operator with Dirichlet and Neumann type boundary conditions are essentially used. Theorems on the orthonomization and completeness of the systems of eigenfunctions of the problems under consideration are proved. Examples of the corresponding parameters for special cases involved in the problems under consideration are given. In addition, in the two-dimensional case for the corresponding nonlocal biharmonic operator, spectral issues of boundary value problems of the Samarsky-Ionkin type are also investigated. The proper and attached functions of the problem under consideration are found and theorems on the completeness ofthese systems are proved.
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