Abstract The biharmonic equation is one of the important equations of mathematical physics, describing the behaviour of harmonic functions in higher-dimensional spaces. The main purpose of this study was to construct a finite-dimensional perturbation for the Dirichlet boundary value problem associated with the biharmonic equation. The methodological basis for this study was an integrated approach that includes mathematical analysis, algebraic methods, operator theory, and the theorem on the existence and uniqueness of a solution for a boundary value. The main tool is a finite-dimensional perturbation, which allows for examining the properties and behaviour of boundary value problems in as much detail as possible. In the study, descriptions of correctly solvable internal boundary value problems for a biharmonic equation in non-simply connected domains were considered in detail. The study is also devoted to the search for solutions and the analytical representation of resolvents of boundary value problems for a biharmonic equation in multi-connected domains. Within the framework of the study, theorems and their consequences were proved, and a finite-dimensional perturbation was constructed for the Dirichlet boundary value problem. Analytical representations of resolvents of boundary value problems for a biharmonic equation in multi-connected domains were also obtained. The examination of a finite-dimensional perturbation of the Dirichlet boundary value problem for a biharmonic equation has expanded the understanding of the properties of this equation in various contexts.