Due to the failure of string seals, gas can leak and result in the abnormal annulus pressure in gas wells, so it is necessary to relieve the pressure in gas wells. In the process of pressure relief, the leaked gas enters the annulus, causes a the great disturbance to the annulus flow field, and thus reduces the protection performance of the annular protection fluid in the string. In order to investigate the influence of gas leakage on the annular flow field, a VOF finite element model of the gas-liquid two-phase flow disturbed by gas leakage in a casing was established to simulate the transient flow field in the annular flow disturbed by gas leakage, and the influences of leakage pressure differences, leakage direction, and leakage time on annular flow field disturbance and wall shear force were analyzed. The analysis results showed that the larger leakage pressure difference corresponded to the faster diffusion rate of the leaked gas in the annulus, the faster the flushing rate of the leaked gas against the casing wall, and a larger shear force on the tubing wall was detrimental to the formation of the corrosion inhibitor film on the tubing wall and casing wall. Under the same conditions, the shear action on the outer wall of tubing in the leakage direction of 90° was stronger than that in the leakage directions of 135° and 45° and the diffusion range was also larger. With the increase in leakage time, leaked gas further moved upward in the annulus and the shear effect on the outer wall of tubing was gradually strengthened. The leaked acid gas flushed the outer wall of casing, thus increasing the peeling-off risk of the corrosion inhibitor film. The study results show that the disturbance law of gas leakage to annular protection fluid is clear, and it was suggested to reduce unnecessary pressure relief time in the annulus to ensure the safety and integrity of gas wells.