The article systematizes main directions of improving organizational and economic support of higher education innovative development in the globalization context. One of the main intensification directions of innovative activity in the higher education field is the creation of a national strategy for innovative higher education development, synchronized with existing programs for the development of domestic higher education system and national economy in general. Authors emphasize that the policy of targeted financing of higher education system innovative development requires optimization. Prerequisites for university innovative development are the availability of state support, adequate financial support, lack of bureaucracy, presence of a developed innovation infrastructure, developed innovation culture in society and more. Promising areas for further universities’ development are also identified: deepening the relationship between higher education, science and industry, particularly in the direction of scientific research commercialization; ensuring university autonomy (including financial autonomy), flexibility and digitalization of higher education; use of distance learning; regular educational material updating in accordance with business demands and scientific-technological progress latest achievements.