This paper deals with an employment of the complex modulators and generalized receivers constructed based on the generalized approach to signal processing (GASP) in noise in quaternary direct-sequence spread-spectrum multiple-access (DS-SSMA) communication systems with complex signature sequences in flat Rayleigh fading. Owing to availability of large sets of complex spreading sequences possessing perfect correlation characteristics, the interest to use the complex spreading sequences in DS-SSMA communication systems has increased. The complex spreading sequences investigated in the present paper are based on the recently introduced orthogonal unified complex Hadamard transform (UCHN) sequences. In the present paper, the complex processing in modulators and generalized receivers is also employed with the purpose to take advantage of the correlation properties of complex signature sequences. We derive the average bit error rate (BER) for quarternary synchronous communications system based on the generalized approach to signal processing in noise first, and then the BER for quaternary asynchronous ones is evaluated using the characteristic function approach. We presented some results based on the Gaussian approximation method for asynchronous communication systems constructed on the basis of the generalized approach to signal processing in noise Computer modeling results demonstrate that the communication systems using UCHT spreading sequences perform generally better than the GOLD sequences and the 4-phase family A sequences. Comparative analysis between the asynchronous communication systems constructed on the basis of the generalized approach to signal processing in noise demonstrates superiority over the asynchronous communication systems employing the correlation receiver.