Review question/objective The objective of this review is to assess and synthesize the best available evidence on the effectiveness of interventions to manage treatment adherence of adult heart transplant patients. Therefore, the review question is: in adult heart transplant patients, what interventions are the most effective to manage adherence to pharmacological and non-pharmacological treatments? Inclusion criteria Types of participants The review will consider patients, 18 years of age or older, regardless of gender, ethnicity, comorbidities, or other treatments, with heart or heart-lung transplantation receiving specific pharmacological and non-pharmacological treatments. Types of intervention(s) The review will consider interventions for managing treatment adherence of heart transplant patients. We will consider any intervention tailored and applied to maintain heart transplant patients using the prescribed pharmacological and non-pharmacological treatment. Examples of such intervention are: a) measures to prepare a patient to safely take prescribed medications/regimens and monitor for their effects (Medication Administration, or Medication Management ); b) measures to “promote behavior acquisition/change” (Behavior Modification ); c) measures to provide “instructions and learning experiences to facilitate voluntary adaptation of behavior conducive to health in individuals, families, or groups” (Health Education ); d) measures to reinforce “self-directed change initiated by the patient to achieve personally important goals” (Self-Modification Assistance); e) measures to encourage “a patient to assume more responsibility for own behavior” (Self-Responsibility Facilitation ); and f) measures to provide “the necessary information, advocacy, and support to facilitate primary patient care by someone other than a health care professional” (Caregiver Support ). Comparator(s) Foreseen comparisons of intervention trials include those between any interventions applied to maintain heart transplant patients using the prescribed pharmacological and non-pharmacological treatment versus standard or routine care, or no additional care. Types of outcomes The review will consider studies that assessed, objectively or by self-report using validated instruments, patient adherence to pharmacological or non-pharmacological treatment. For this systematic review, patient adherence to pharmacological or non-pharmacological treatment is defined as the extent to which a person’s behavior – taking the medication, following a diet plan and/or make changes to their life style, corresponds to the recommendations of a caregiver, regardless of any agreement about following the recommendation because authors do not usually consider this element defined by the WHO. Objective assessment of patient adherence to pharmacological or non-pharmacological treatment refers to direct observation of behavior, electronic monitoring, or serum dosage of pharmacological agents.